2,4,5-trimethylaniline;hydrochloride
C9H14ClN
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Identification
- CAS Number
- 21436-97-5
- UN Number
- 2811
- Index Number
- 612-197-00-6
- PubChem CID
- 5284470
Physical-chemical properties
- Molecular Formula
- C9H14ClN
- Molar Mass
- 171.67 g/mol
- IUPAC Name
- 2,4,5-trimethylaniline;hydrochloride
Chemical Identifiers
- InChI
- InChI=1S/C9H13N.ClH/c1-6-4-8(3)9(10)5-7(6)2;/h4-5H,10H2,1-3H3;1H
- InChI Key
- HPSNPQBFMPYUOD-UHFFFAOYSA-N
Overview
2,4,5-trimethylaniline hydrochloride (CAS 21436-97-5) is an aromatic amine derivative characterized by high toxicity and carcinogenic properties requiring specialized handling protocols. This substituted aniline compound represents a critical intermediate in organic synthesis, distinguished by three methyl substituents on the benzene ring at positions 2, 4, and 5, combined with an amino group. The hydrochloride salt form enhances stability and solubility compared to the free base, making it more suitable for industrial applications and storage. With a molecular formula of C9H14ClN and molecular weight of 171.67 g/mol, this compound exhibits significant biological activity that necessitates stringent safety measures. The substance carries severe health hazard classifications including Category 1B carcinogenicity and Category 3 acute toxicity through multiple exposure routes. Its hazard profile shares similarities with related aromatic amines such as N-methylaniline, which also requires careful handling due to toxicological concerns. The ADR Class 6.1 classification underscores its status as a toxic substance requiring specialized transport and storage conditions. Environmental considerations include moderate aquatic toxicity with chronic effects classification. Primary industrial applications focus on pharmaceutical intermediate synthesis, where precise structural modifications are essential for drug development. The compound also serves in specialty dye manufacturing and advanced organic synthesis where specific methylation patterns are required. Research applications utilize this material in medicinal chemistry studies and as a building block for complex molecular structures. OYSI maintains availability of 2,4,5-trimethylaniline hydrochloride through our specialized dangerous goods supply chain, ensuring proper regulatory compliance and technical support for qualified industrial customers requiring this controlled substance.
Safety & Classification
Carc. 1B; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Chronic 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2811 |
| ADR Class | 6.1 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | 2,4,5-Trimethylanilin-hydrochlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is 2,4,5-trimethylaniline;hydrochloride?
2,4,5-trimethylaniline;hydrochloride is an aromatic amine compound with the molecular formula C9H14ClN and CAS number 21436-97-5. This chemical substance has a molecular weight of 171.67 g/mol and belongs to the class of substituted anilines. It is classified as a carcinogenic substance (Category 1B) and presents acute toxicity hazards, requiring careful handling in industrial applications.
What are the physicochemical properties of 2,4,5-trimethylaniline;hydrochloride?
2,4,5-trimethylaniline;hydrochloride is typically a crystalline solid at room temperature due to its hydrochloride salt form. As an aniline derivative, it generally exhibits good solubility in polar solvents like water and alcohols. The compound contains three methyl substituents on the benzene ring at positions 2, 4, and 5, which influence its physical properties and chemical reactivity compared to unsubstituted aniline.
What is 2,4,5-trimethylaniline;hydrochloride used for?
2,4,5-trimethylaniline;hydrochloride is primarily used as an intermediate in organic synthesis and chemical manufacturing processes. Its applications include the production of dyes, pigments, and pharmaceutical intermediates. The compound serves as a building block for various aromatic compounds in specialty chemical synthesis. Due to its carcinogenic classification, its use is restricted to professional and industrial applications with appropriate safety measures.
How to handle 2,4,5-trimethylaniline;hydrochloride safely?
2,4,5-trimethylaniline;hydrochloride requires strict safety protocols due to its carcinogenic and acute toxicity properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion. Use appropriate engineering controls and ensure workers are trained in handling carcinogenic substances according to occupational safety regulations.
How to store 2,4,5-trimethylaniline;hydrochloride correctly?
2,4,5-trimethylaniline;hydrochloride should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Storage areas must be secure and accessible only to authorized personnel due to its carcinogenic properties. Keep away from oxidizing agents and strong acids. Ensure proper labeling with hazard warnings and maintain appropriate inventory records for regulatory compliance.
What to do in case of contact with 2,4,5-trimethylaniline;hydrochloride?
Immediate action is required upon contact with 2,4,5-trimethylaniline;hydrochloride. For skin contact, remove contaminated clothing and flush the affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air. For ingestion, do not induce vomiting and seek immediate medical care. Always consult a physician and provide safety data sheet information.
How to dispose of 2,4,5-trimethylaniline;hydrochloride appropriately?
2,4,5-trimethylaniline;hydrochloride must be disposed of as hazardous waste according to local and national regulations due to its carcinogenic classification. Disposal should only be carried out by licensed waste management companies specialized in handling carcinogenic substances. Never dispose of in regular waste streams or pour down drains. Container disposal must follow the same hazardous waste protocols, and all disposal activities must be documented for regulatory compliance.
How to transport 2,4,5-trimethylaniline;hydrochloride?
2,4,5-trimethylaniline;hydrochloride is classified under ADR Class 6.1 (toxic substances), Packing Group II, indicating significant transport restrictions. Transportation requires appropriate UN-approved packaging, proper labeling with GHS pictograms (GHS06, GHS08, GHS09), and shipping documentation. Only certified carriers experienced in handling toxic chemicals should transport this substance. Emergency response information must accompany shipments, and drivers require hazardous materials training certification.
Is 2,4,5-trimethylaniline;hydrochloride subject to specific regulations?
2,4,5-trimethylaniline;hydrochloride is subject to strict regulatory oversight under REACH and CLP regulations due to its carcinogenic Category 1B classification. The substance requires comprehensive risk assessments, safety data sheets, and may have restrictions on use and marketing. Occupational exposure limits and specific workplace controls are mandated. Users must comply with carcinogen handling regulations and may need special authorizations for certain applications under European chemical legislation.
Where to buy 2,4,5-trimethylaniline;hydrochloride in Europe?
2,4,5-trimethylaniline;hydrochloride is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI provides this regulated substance to qualified industrial customers with proper documentation and regulatory compliance support. Purchase requires verification of legitimate use and appropriate handling capabilities due to the substance's carcinogenic classification. Contact OYSI directly for availability, technical specifications, and regulatory guidance for your specific application.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.