5-methyl-2-nitroaniline

C7H8N2O2

CAS578-46-1
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
578-46-1
EC Number
209-423-7
UN Number
2660
Index Number
612-025-00-X
PubChem CID
11356

Physical-chemical properties

Molecular Formula
C7H8N2O2
Molar Mass
152.15 g/mol
IUPAC Name
5-methyl-2-nitroaniline

Chemical Identifiers

InChI
InChI=1S/C7H8N2O2/c1-5-2-3-7(9(10)11)6(8)4-5/h2-4H,8H2,1H3
InChI Key
IGDYNWKWXUCIJB-UHFFFAOYSA-N

Overview

5-methyl-2-nitroaniline (CAS 578-46-1) is an aromatic nitroaniline compound with methyl substitution exhibiting significant toxicological properties. This organic chemical compound, with molecular formula C7H8N2O2 and molecular weight 152.15 g/mol, belongs to the nitroaniline family of aromatic amines. The substance features both nitro and amino functional groups attached to a methylated benzene ring, creating a versatile intermediate for various chemical syntheses. Its structural configuration positions the methyl group at the 5-position and the nitro group at the 2-position relative to the amino group, distinguishing it from other nitroaniline isomers. 5-methyl-2-nitroaniline presents serious safety considerations, classified under multiple acute toxicity categories and requiring careful handling protocols. The compound carries GHS pictograms for toxicity (GHS06), health hazards (GHS08), and environmental hazards (GHS09), with a "Danger" signal word. Its classification as ADR class 6.1 indicates toxic substance properties requiring specialized transportation procedures. The substance also poses risks for specific target organ toxicity following repeated exposure and chronic aquatic toxicity. Primary industrial applications include its use as an intermediate in pharmaceutical synthesis, dye manufacturing, and agrochemical production. The compound serves as a building block for creating more complex molecular structures, particularly in the development of specialized colorants and medicinal compounds. Like related aromatic amines such as 3,5-dimethylaniline, it plays a crucial role in organic synthesis pathways requiring functionalized aniline derivatives. OYSI provides 5-methyl-2-nitroaniline to European industrial customers, ensuring compliance with all relevant chemical safety regulations and transportation requirements for this controlled substance.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2660
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name6-Nitro-m-toluidin, fest
Marine PollutantNo

Frequently Asked Questions

What is 5-methyl-2-nitroaniline?

5-methyl-2-nitroaniline is an organic chemical compound with the molecular formula C7H8N2O2 and CAS number 578-46-1. This aromatic amine derivative belongs to the nitroaniline family and has a molecular weight of 152.15 g/mol. It is classified as a hazardous substance with acute toxicity and chronic health effects, requiring careful handling in industrial applications.

What are the physicochemical properties of 5-methyl-2-nitroaniline?

5-methyl-2-nitroaniline is typically a crystalline solid at room temperature with a characteristic aromatic amine odor. As an aromatic nitro compound, it exhibits limited water solubility but dissolves well in organic solvents like ethanol and acetone. The compound appears as colored crystals, and its nitro group makes it sensitive to heat and light, requiring proper storage conditions.

What is 5-methyl-2-nitroaniline used for?

5-methyl-2-nitroaniline is primarily used as an intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. It serves as a building block in organic chemistry for producing various aromatic derivatives. The compound is also utilized in the manufacture of specialty chemicals and as a precursor for developing agrochemicals and other fine chemical products in industrial applications.

How to handle 5-methyl-2-nitroaniline safely?

5-methyl-2-nitroaniline requires strict safety measures due to its Acute Tox. 3 classification and STOT RE 2 hazard class. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion, as the compound poses serious health risks through multiple exposure routes.

How to store 5-methyl-2-nitroaniline correctly?

5-methyl-2-nitroaniline must be stored in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and incompatible materials. Keep containers tightly sealed and properly labeled according to GHS requirements. Store separately from strong oxidizers, acids, and bases. Ensure storage areas have appropriate spill containment measures and are accessible only to trained personnel due to the compound's hazardous nature.

What to do in case of contact with 5-methyl-2-nitroaniline?

Immediate action is required in case of contact with 5-methyl-2-nitroaniline due to its acute toxicity. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. If inhaled, move to fresh air immediately. In case of eye contact, flush with clean water for 15 minutes. Seek medical attention promptly for any exposure, and provide the safety data sheet to medical personnel.

How to dispose of 5-methyl-2-nitroaniline appropriately?

5-methyl-2-nitroaniline must be disposed of as hazardous waste through licensed waste management companies in accordance with local and European regulations. Never dispose of this compound in regular waste streams or pour down drains due to its environmental hazard classification (Aquatic Chronic 2). Collect waste in appropriate containers, label clearly, and ensure proper documentation for the disposal chain as required by waste regulations.

How to transport 5-methyl-2-nitroaniline?

5-methyl-2-nitroaniline is classified as ADR Class 6.1 (toxic substances), Packing Group III for transportation purposes. Packages must bear appropriate hazard labels and comply with ADR packaging requirements for toxic substances. Transport vehicles need proper placarding and documentation. Only authorized carriers with appropriate training and equipment should handle the transportation of this hazardous chemical compound across European borders.

Is 5-methyl-2-nitroaniline subject to particular regulations?

5-methyl-2-nitroaniline is subject to REACH registration requirements and CLP classification regulations in Europe. The compound is not currently listed as a SVHC (Substance of Very High Concern). However, its hazardous classification requires compliance with occupational safety regulations, environmental protection laws, and proper labeling according to GHS pictogrammes GHS06, GHS08, and GHS09 with the signal word 'Danger'.

Where to buy 5-methyl-2-nitroaniline in Europe?

5-methyl-2-nitroaniline is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI provides this compound to industrial customers across Europe with proper documentation, safety data sheets, and regulatory compliance. Contact OYSI directly for availability, packaging options, and delivery to your location while ensuring your organization meets the requirements for handling this hazardous substance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.