N-methylaniline

C7H9N

CAS100-61-8
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
100-61-8
EC Number
202-870-9
UN Number
2294
Index Number
612-015-00-5
PubChem CID
7515

Physical-chemical properties

Molecular Formula
C7H9N
Molar Mass
107.15 g/mol
IUPAC Name
N-methylaniline

Chemical Identifiers

InChI
InChI=1S/C7H9N/c1-8-7-5-3-2-4-6-7/h2-6,8H,1H3
InChI Key
AFBPFSWMIHJQDM-UHFFFAOYSA-N

Overview

N-methylaniline (CAS 100-61-8) is an aromatic amine compound with significant industrial applications and notable toxicological properties requiring careful handling protocols. This organic chemical compound, also known by its IUPAC designation N-methylaniline, represents a derivative of aniline where one hydrogen atom on the amino group has been substituted with a methyl group. With the molecular formula C7H9N and a molecular weight of 107.15 g/mol, N-methylaniline exhibits the characteristic properties of aromatic amines while displaying distinct reactivity patterns due to its methylated nitrogen functionality. The compound presents significant safety considerations, classified under multiple acute toxicity categories and requiring stringent handling procedures. Its hazard profile includes acute toxicity through oral, dermal, and inhalation routes, specific target organ toxicity following repeated exposure, and notable environmental concerns due to its aquatic toxicity classification. These properties necessitate comprehensive safety protocols during storage, handling, and transportation, reflected in its ADR classification as a Class 6.1 substance. N-methylaniline serves as a crucial intermediate in various industrial synthesis processes, particularly in the production of dyes, pharmaceuticals, and specialty chemicals. The compound finds extensive application in the manufacture of antioxidants and as a chemical intermediate in organic synthesis reactions. Its reactivity profile makes it valuable for producing compounds requiring selective nitrogen functionalization, distinguishing it from related substances like N-phenylaniline which offers different substitution patterns. The chemical's industrial significance extends to its role in producing various nitrogen-containing compounds where controlled reactivity is essential. Quality control and proper handling protocols are paramount given its toxicological profile and environmental impact potential. OYSI provides N-methylaniline to qualified industrial customers with comprehensive technical support and safety documentation to ensure compliant handling and application.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2294
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameN-Methylanilin
Marine PollutantNo

Frequently Asked Questions

What is N-methylaniline?

N-methylaniline is an organic aromatic amine compound with the chemical formula C7H9N and CAS number 100-61-8. It consists of an aniline molecule where one hydrogen atom on the amino group has been replaced by a methyl group. With a molecular weight of 107.15 g/mol, this substance is classified as a toxic chemical requiring careful handling due to its acute toxicity and environmental hazards.

What are the physicochemical properties of N-methylaniline?

N-methylaniline is typically a colorless to pale yellow liquid at room temperature with a characteristic amine-like odor. It has limited solubility in water but is soluble in organic solvents such as alcohols and ethers. The compound is sensitive to light and air, which can cause oxidation and color changes. Its aromatic amine structure makes it reactive toward acids and oxidizing agents.

What is N-methylaniline used for?

N-methylaniline serves as an important intermediate in the chemical industry, primarily for manufacturing dyes, pigments, and pharmaceutical compounds. It is used in the synthesis of various organic chemicals including antioxidants, accelerators for rubber vulcanization, and specialty chemicals. The compound also finds application in analytical chemistry as a reagent and in research laboratories for organic synthesis reactions.

How to handle N-methylaniline safely?

N-methylaniline requires strict safety measures due to its Acute Tox. 3 classification and DANGER signal word. Always wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Avoid skin contact and inhalation as the substance can be absorbed through skin and cause systemic toxicity. Work in fume hoods and ensure emergency shower and eyewash stations are accessible.

How to store N-methylaniline correctly?

N-methylaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep away from incompatible materials such as strong oxidizers, acids, and bases. Storage areas must be equipped with appropriate containment systems and comply with local regulations for toxic substances. Maintain temperatures below recommended limits to prevent decomposition.

What to do in case of contact with N-methylaniline?

Immediate action is crucial due to N-methylaniline's acute toxicity. For skin contact, remove contaminated clothing and wash thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with plenty of water for 15 minutes. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention immediately. Always consult safety data sheets for detailed first aid measures.

How to dispose of N-methylaniline appropriately?

N-methylaniline disposal must comply with local and European waste regulations due to its toxic and environmentally hazardous properties (Aquatic Acute 1, Aquatic Chronic 1). The substance should be treated as hazardous waste and disposed of through licensed waste management facilities. Never discharge into sewers, waterways, or soil. Incineration at authorized high-temperature facilities is typically the preferred disposal method for this type of aromatic amine.

How to transport N-methylaniline?

N-methylaniline is classified under ADR as Class 6.1 (toxic substances), Packing Group III, requiring appropriate dangerous goods packaging and labeling. Transport must comply with ADR/RID regulations for toxic substances, including proper packaging, marking with UN numbers, and dangerous goods documentation. Only authorized carriers with dangerous goods training should handle transportation, and emergency response information must accompany shipments.

Is N-methylaniline subject to specific regulations?

N-methylaniline is subject to REACH registration requirements in Europe and must comply with CLP classification and labeling regulations. While not currently listed as an SVHC (Substance of Very High Concern), its toxic properties mean it may be subject to workplace exposure limits and industrial emission controls. Companies using this substance must ensure proper risk assessments, safety data sheets, and worker protection measures are in place.

Where to buy N-methylaniline in Europe?

N-methylaniline is available through OYSI, a European distributor specializing in technical chemicals. As an established chemical distributor, OYSI can provide N-methylaniline with proper documentation, safety data sheets, and regulatory compliance support. For procurement inquiries, technical specifications, or regulatory guidance, contact OYSI directly to discuss your specific requirements and ensure proper handling of this regulated toxic substance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.