Aniline

C6H7N

aniline

CAS62-53-3
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
62-53-3
EC Number
200-539-3
UN Number
1547
Index Number
612-008-00-7
PubChem CID
6115

Physical-chemical properties

Molecular Formula
C6H7N
Molar Mass
93.13 g/mol
IUPAC Name
aniline

Chemical Identifiers

InChI
InChI=1S/C6H7N/c7-6-4-2-1-3-5-6/h1-5H,7H2
InChI Key
PAYRUJLWNCNPSJ-UHFFFAOYSA-N

Overview

Aniline (CAS 62-53-3) is an aromatic amine compound with significant industrial importance and notable toxicological properties requiring careful handling protocols. As one of the most fundamental building blocks in organic chemistry, aniline serves as a crucial intermediate in numerous industrial processes. This colorless to pale yellow liquid, with the molecular formula C6H7N and a molecular weight of 93.13 g/mol, is characterized by its distinctive amine odor and its role as a primary aromatic amine. The compound's structure consists of a benzene ring directly attached to an amino group, making it highly reactive and versatile for chemical synthesis applications. From a safety perspective, aniline presents significant hazards that require stringent handling procedures. The substance is classified as a Category 2 carcinogen and mutagen, with acute toxicity properties across multiple exposure routes. The GHS pictograms GHS08, GHS06, GHS05, and GHS09 indicate its serious health hazards, corrosive properties, and environmental concerns. As a Class 6.1 substance under ADR regulations, aniline requires specialized transport and storage conditions. Exposure can cause methemoglobinemia, a serious condition affecting oxygen transport in blood, making proper personal protective equipment and ventilation systems essential. The primary industrial applications of aniline include the production of polyurethane foams, where it serves as a precursor for methylene diphenyl diisocyanate (MDI), and the manufacture of dyes and pigments. It is also utilized in rubber processing chemicals and pharmaceutical intermediates. Related compounds such as aniline hydrochloride share similar applications in specialized chemical synthesis, while substances like 1-chloro-4-isocyanatobenzene represent downstream derivatives in the polyurethane production chain. OYSI provides high-quality aniline to European industrial customers, ensuring compliance with all relevant safety and regulatory requirements for this critical chemical intermediate.

Safety & Classification

Danger
Classification:

Carc. 2; Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1; Eye Dam. 1; Skin Sen...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H341

Suspected of causing genetic defects.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H372

Causes damage to organs through prolonged or repeated exposure.

H318

Causes serious eye damage.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1547
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameAnilin
Marine PollutantNo

Frequently Asked Questions

What is aniline?

Aniline is an aromatic amine compound with the chemical formula C6H7N and CAS number 62-53-3. It consists of a benzene ring with an amino group (-NH2) attached, making it the simplest aromatic amine. With a molecular weight of 93.13 g/mol, aniline is classified as a hazardous substance with significant toxicity concerns, including carcinogenic and mutagenic properties. It serves as a crucial building block in organic synthesis and chemical manufacturing.

What are the physicochemical properties of aniline?

Aniline is a colorless to pale yellow oily liquid with a characteristic fishy or ammonia-like odor at room temperature. It has a boiling point of 184°C and is slightly soluble in water but highly soluble in organic solvents like ethanol and benzene. The compound darkens upon exposure to air and light due to oxidation. Its aromatic amine structure gives it basic properties, and it readily forms salts with acids.

What is aniline used for?

Aniline is primarily used as an intermediate in the production of polyurethane foams, dyes, and pigments. It serves as a key raw material for manufacturing methylene diphenyl diisocyanate (MDI), which is essential for polyurethane production. Additionally, aniline is used in the synthesis of pharmaceuticals, rubber processing chemicals, pesticides, and antioxidants. The textile industry also relies on aniline derivatives for producing various synthetic dyes and colorants.

How to handle aniline safely?

Aniline requires strict safety measures due to its high toxicity and carcinogenic properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Skin and eye contact must be avoided completely, as aniline can be absorbed through the skin. Work should be conducted in fume hoods with adequate ventilation, and emergency shower and eyewash stations should be readily accessible during handling operations.

How to store aniline correctly?

Aniline must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and incompatible materials. Storage areas should be equipped with secondary containment and maintained below 25°C to prevent decomposition. The compound should be kept away from strong oxidizing agents, acids, and metals. Storage facilities must comply with local regulations for toxic substances and include appropriate fire suppression systems.

What to do in case of contact with aniline?

Immediate action is critical for aniline exposure due to its high toxicity. For skin contact, remove contaminated clothing and rinse affected areas with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water for 15-20 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult emergency services for any exposure incident.

How to dispose of aniline properly?

Aniline disposal must comply with local hazardous waste regulations due to its toxic and carcinogenic properties. The substance should never be poured down drains or disposed of with regular waste. Professional hazardous waste disposal services must handle aniline waste through approved methods such as high-temperature incineration with proper emission controls. All containers must be properly labeled and documented according to waste tracking requirements before disposal.

How to transport aniline?

Aniline is classified as ADR Class 6.1 (toxic substances), Packing Group II, requiring specific transport protocols. It must be packaged in approved containers with proper hazard labels and documentation. Transport vehicles need appropriate placarding and emergency response information. Drivers must hold valid dangerous goods transport certificates, and shipments require proper shipping papers with emergency contact information and handling instructions for potential incidents during transit.

Is aniline subject to specific regulations?

Aniline is subject to extensive regulatory oversight under REACH, CLP, and various national chemical safety regulations. It requires registration for commercial use and is classified with multiple hazard categories including Carc. 2, Muta. 2, and Acute Tox. 3. Although not currently listed as an SVHC, its carcinogenic and mutagenic properties place it under strict control measures. Industrial users must comply with occupational exposure limits and implement appropriate risk management measures.

Where to buy aniline in Europe?

OYSI serves as a reliable European distributor for aniline, providing quality chemical products to industrial customers across Europe. As an established chemical distributor, OYSI can supply aniline with proper documentation, safety data sheets, and regulatory compliance support. Professional customers requiring aniline for industrial applications can contact OYSI for availability, technical specifications, and delivery options tailored to their specific requirements and regional regulations.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.