Chlorobenzene

C6H5Cl

chlorobenzene

CAS108-90-7
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
108-90-7
EC Number
203-628-5
UN Number
1134
Index Number
602-033-00-1
PubChem CID
7964

Physical-chemical properties

Molecular Formula
C6H5Cl
Molar Mass
112.55 g/mol
IUPAC Name
chlorobenzene

Chemical Identifiers

InChI
InChI=1S/C6H5Cl/c7-6-4-2-1-3-5-6/h1-5H
InChI Key
MVPPADPHJFYWMZ-UHFFFAOYSA-N

Overview

Chlorobenzene (CAS 108-90-7) is an aromatic halogenated hydrocarbon with excellent solvent properties and moderate flammability characteristics. This colorless liquid compound represents one of the simplest aromatic chlorine derivatives, featuring a benzene ring with a single chlorine substituent. With its molecular formula C6H5Cl and molar mass of 112.55 g/mol, chlorobenzene exhibits distinctive physicochemical properties that make it valuable across multiple industrial sectors. The substance displays typical aromatic stability while maintaining sufficient reactivity for various chemical transformations. From a safety perspective, chlorobenzene is classified as a flammable liquid category 3 with acute toxicity category 4 properties. The compound requires careful handling due to its potential for skin irritation and chronic aquatic toxicity. Its GHS classification includes pictograms for flammability, health hazards, and environmental concerns, emphasizing the need for appropriate safety measures during storage, handling, and transportation under ADR class 3 regulations. Industrial applications of chlorobenzene span several key sectors, primarily serving as an intermediate in pharmaceutical and agrochemical synthesis. The compound functions effectively as a solvent for various organic reactions and finds extensive use in the production of aniline derivatives through nucleophilic substitution processes. Additionally, it serves as a precursor for specialty chemicals and rubber processing aids. Like other aromatic compounds such as 1,3,5-trimethylbenzene and bromobenzene, chlorobenzene benefits from the inherent stability of the benzene ring system while offering unique reactivity through its halogen substituent. OYSI maintains reliable supply chains for chlorobenzene to support European industrial customers requiring consistent quality and technical support for their chemical processes.

Safety & Classification

Warning
Classification:

Flam. Liq. 3; Acute Tox. 4; Skin Irrit. 2; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H332

Harmful if inhaled.

H315

Causes skin irritation.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1134
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping NameChlorbenzen
Marine PollutantNo

Frequently Asked Questions

What is chlorobenzene?

Chlorobenzene is an aromatic organic compound with the molecular formula C6H5Cl and CAS number 108-90-7. It consists of a benzene ring with one chlorine atom substituted for a hydrogen atom. With a molecular weight of 112.55 g/mol, chlorobenzene is classified as a flammable liquid with moderate toxicity and skin irritation properties. It appears as a colorless liquid with a characteristic sweet, almond-like odor and is widely used as an industrial solvent and chemical intermediate.

What are the physicochemical properties of chlorobenzene?

Chlorobenzene is a colorless, transparent liquid at room temperature with a distinctive sweet, almond-like odor. It has a boiling point of 131.7°C and a melting point of -45.6°C. The compound is practically insoluble in water but readily miscible with most organic solvents including alcohols, ethers, and hydrocarbons. It has a density of approximately 1.106 g/cm³ at 20°C and exhibits good chemical stability under normal conditions.

What is chlorobenzene used for?

Chlorobenzene is primarily used as a solvent for paints, adhesives, rubber, and waxes due to its excellent dissolving properties. It serves as an important chemical intermediate in the production of phenol, aniline, and various pesticides. The compound is also utilized in the manufacture of dyes, pharmaceuticals, and specialty chemicals. Additionally, chlorobenzene finds application in metal degreasing operations and as a heat transfer medium in certain industrial processes.

How to handle chlorobenzene safely?

Chlorobenzene must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under local exhaust ventilation to minimize inhalation exposure. Avoid contact with heat sources, sparks, and open flames as it is a flammable liquid. Use non-sparking tools and ensure proper grounding of equipment. Always wash hands thoroughly after handling and avoid eating, drinking, or smoking in work areas.

How to store chlorobenzene correctly?

Chlorobenzene should be stored in tightly closed containers in a cool, dry, and well-ventilated area away from heat sources, ignition sources, and direct sunlight. Storage areas must be equipped with appropriate fire suppression systems due to its flammable nature. Keep containers away from incompatible materials such as strong oxidizing agents and alkali metals. Ensure proper secondary containment and regularly inspect containers for leaks or damage. Storage temperature should remain below 25°C when possible.

What to do in case of contact with chlorobenzene?

Immediate action is required upon contact with chlorobenzene. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush immediately with clean water for 15-20 minutes and remove contact lenses if easily removable. In case of inhalation, move the person to fresh air immediately. If ingested, do not induce vomiting and seek immediate medical attention. Always consult a physician after any significant exposure.

How to dispose of chlorobenzene appropriately?

Chlorobenzene must be disposed of as hazardous waste through licensed waste management facilities in accordance with local and EU regulations. Never dispose of it down drains, sewers, or into the environment due to its aquatic toxicity. Small quantities should be collected in appropriate containers and labeled clearly for hazardous waste collection. Larger quantities require professional hazardous waste disposal services. Always consult local environmental authorities for specific disposal requirements and ensure compliance with REACH and waste framework directive regulations.

How to transport chlorobenzene?

Chlorobenzene is classified under ADR as Class 3 (flammable liquids), Packing Group III, requiring specific transport regulations. It must be packaged in UN-approved containers with proper hazard labels and documentation. Transport vehicles must comply with ADR requirements including appropriate placarding, emergency equipment, and driver training. Shipping documents must include the proper shipping name, UN number, and hazard class. Only authorized carriers with ADR certification should transport this substance.

Is chlorobenzene subject to specific regulations?

Chlorobenzene is regulated under multiple European frameworks including REACH, CLP, and ADR regulations. It requires registration under REACH and must be classified and labeled according to CLP with Warning signal word and GHS pictograms GHS02, GHS07, and GHS09. However, it is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational exposure limits and environmental discharge restrictions. Industrial users may require specific permits depending on quantities handled and local regulations.

Where to buy chlorobenzene in Europe?

Chlorobenzene is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across Europe. As a professional chemical distributor, OYSI provides high-quality chlorobenzene with proper documentation, safety data sheets, and regulatory compliance support. We serve various industries requiring this solvent and chemical intermediate. Contact OYSI directly for specific grades, packaging options, and delivery arrangements to your location within Europe. Professional technical support is available for all product inquiries.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.