Phenol

C6H6O

phenol

CAS108-95-2
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
108-95-2
EC Number
203-632-7
UN Number
2312
Index Number
604-001-00-8
PubChem CID
996

Physical-chemical properties

Molecular Formula
C6H6O
Molar Mass
94.11 g/mol
IUPAC Name
phenol

Chemical Identifiers

InChI
InChI=1S/C6H6O/c7-6-4-2-1-3-5-6/h1-5,7H
InChI Key
ISWSIDIOOBJBQZ-UHFFFAOYSA-N

Overview

Phenol (CAS 108-95-2) is an aromatic organic compound with a hydroxyl group directly bonded to a benzene ring, serving as a fundamental building block in chemical synthesis. This crystalline solid, also known by its IUPAC name phenol, represents one of the most important industrial chemicals with the molecular formula C6H6O and a molecular weight of 94.11 g/mol. Phenol exhibits distinctive properties that make it valuable across numerous industrial applications, though its hazardous nature requires careful handling and strict safety protocols. The compound presents significant safety considerations, classified under multiple danger categories including mutagenicity (Muta. 2), acute toxicity through various exposure routes (Acute Tox. 3), specific target organ toxicity with repeated exposure (STOT RE 2), and severe skin corrosion (Skin Corr. 1B). These classifications mandate the "Danger" signal word and require appropriate GHS pictograms (GHS08, GHS06, GHS05) on packaging. For transportation purposes, phenol falls under ADR class 6.1, reflecting its toxic properties. Phenol's chemical versatility stems from its aromatic structure combined with the reactive hydroxyl group, enabling various chemical transformations. This reactivity profile shares similarities with other aromatic compounds like chloromethylbenzene, which also serves as an intermediate in organic synthesis. The compound's applications span multiple industries, including the production of phenolic resins used in adhesives and coatings, synthesis of pharmaceutical intermediates, and manufacturing of various chemical derivatives. Key industrial applications include phenol-formaldehyde resin production for wood products and insulation materials, synthesis of bisphenol A for polycarbonate plastics, and production of caprolactam for nylon manufacturing. The compound also finds use in pharmaceutical synthesis, where precision and purity are paramount. OYSI maintains reliable supply chains for phenol, ensuring consistent availability of this essential industrial chemical for European customers across diverse manufacturing sectors.

Safety & Classification

Danger
Classification:

Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Skin Corr. 1B

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H341

Suspected of causing genetic defects.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2312
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping NamePhenol, geschmolzen
Marine PollutantNo

Frequently Asked Questions

What is Phenol?

Phenol is an aromatic organic compound with the chemical formula C6H6O and molecular weight of 94.11 g/mol. It consists of a benzene ring with a hydroxyl group (-OH) attached directly to it. Phenol is classified as a highly hazardous substance with corrosive properties, acute toxicity, and mutagenic potential. It appears as white crystalline solid at room temperature with a distinctive sweet, medicinal odor.

What are the physico-chemical properties of Phenol?

Phenol is a white crystalline solid at room temperature with a characteristic sweet, tarry odor. It has a melting point of 40.5°C and boiling point of 181.7°C. Phenol is moderately soluble in water (approximately 8.3 g/100 mL at 20°C) and highly soluble in organic solvents like ethanol and ether. It turns pink or red upon exposure to air and light due to oxidation.

What is Phenol used for?

Phenol is primarily used as an intermediate in chemical synthesis, particularly for producing phenolic resins, bisphenol A, and caprolactam. It serves as a precursor for pharmaceuticals, including aspirin and other medications. Industrial applications include manufacture of plastics, synthetic fibers, dyes, and preservatives. Phenol is also used in laboratory settings as a disinfectant and in molecular biology protocols for DNA and protein extraction.

How to handle Phenol safely?

Phenol requires strict safety measures due to its corrosive and toxic nature. Essential PPE includes chemical-resistant gloves, safety goggles, face shield, and protective clothing covering all skin. Work only in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion completely. Use appropriate tools for handling and never touch with bare hands. Ensure emergency shower and eyewash stations are readily accessible.

How to store Phenol correctly?

Phenol must be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers tightly sealed in original packaging, preferably in secondary containment. Store separately from oxidizing agents, bases, and incompatible materials. Maintain storage temperature below 25°C to prevent melting. Ensure storage area has appropriate spill containment and is accessible only to trained personnel with proper authorization.

What to do in case of contact with Phenol?

Phenol exposure requires immediate emergency response. For skin contact, immediately remove contaminated clothing and flush affected area with copious amounts of water for at least 15 minutes, then seek medical attention. If inhaled, move to fresh air and get medical help. For eye contact, rinse continuously with water for 15 minutes. If ingested, do not induce vomiting and seek immediate medical attention. Always call poison control or emergency services.

How to dispose of Phenol appropriately?

Phenol disposal must comply with local and international hazardous waste regulations. It cannot be disposed of in regular waste streams or poured down drains. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small quantities may require neutralization or incineration at specialized facilities. Document all disposal activities and maintain records as required by environmental regulations. Never attempt amateur disposal methods due to environmental and safety risks.

How to transport Phenol?

Phenol is classified as ADR Class 6.1 (toxic substances), Packing Group II, requiring specialized transport procedures. It must be packaged in UN-approved containers with proper labeling including GHS pictograms (GHS05, GHS06, GHS08). Transport vehicles need appropriate placarding and documentation. Only trained drivers with dangerous goods certification can transport phenol. Emergency response information and safety data sheets must accompany shipments.

Is Phenol subject to specific regulations?

Phenol is subject to comprehensive European chemical regulations under REACH and CLP. It carries multiple hazard classifications including Muta. 2, Acute Tox. 3, STOT RE 2, and Skin Corr. 1B, requiring detailed safety data sheets and risk assessments. While not currently listed as SVHC, its mutagenic properties mean regulatory status could change. Users must comply with occupational exposure limits, worker protection requirements, and environmental discharge restrictions.

Where to buy Phenol in Europe?

Phenol is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI can provide phenol with proper documentation, safety data sheets, and regulatory compliance support. Given phenol's hazardous classification, purchase requires demonstration of legitimate industrial use and appropriate handling capabilities. Contact OYSI's technical team for availability, specifications, and regulatory guidance for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.