Bromobenzene

C6H5Br

bromobenzene

CAS108-86-1
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
108-86-1
EC Number
203-623-8
UN Number
2514
Index Number
602-060-00-9
PubChem CID
7961

Physical-chemical properties

Molecular Formula
C6H5Br
Molar Mass
157.01 g/mol
IUPAC Name
bromobenzene

Chemical Identifiers

InChI
InChI=1S/C6H5Br/c7-6-4-2-1-3-5-6/h1-5H
InChI Key
QARVLSVVCXYDNA-UHFFFAOYSA-N

Overview

Bromobenzene (CAS 108-86-1) is an aromatic halogenated hydrocarbon featuring a bromine atom directly bonded to a benzene ring, exhibiting moderate flammability and skin irritation properties. This colorless to pale yellow liquid compound serves as a fundamental building block in organic synthesis and industrial chemistry. With its molecular formula C6H5Br and molecular weight of 157.01 g/mol, bromobenzene represents one of the simplest aryl bromides, making it an essential intermediate for numerous chemical transformations. The compound exhibits typical aromatic characteristics while the bromine substituent significantly influences its reactivity profile, particularly in nucleophilic substitution and cross-coupling reactions. From a safety perspective, bromobenzene is classified as a flammable liquid (Category 3) requiring standard fire prevention measures during handling and storage. The compound may cause skin irritation upon direct contact, necessitating appropriate personal protective equipment including chemical-resistant gloves and safety glasses. Environmental considerations include its classification as chronically toxic to aquatic life, requiring controlled disposal and spill prevention protocols. Like related aromatic compounds such as chlorobenzene, bromobenzene requires proper ventilation during use to minimize vapor exposure. Industrial applications of bromobenzene span multiple sectors, primarily serving as an intermediate in pharmaceutical synthesis where it enables the introduction of aromatic bromine functionality into drug molecules. The compound also finds extensive use in the production of specialty chemicals and advanced materials, particularly in the synthesis of flame retardants and polymer additives. Additionally, bromobenzene serves as a solvent and reaction medium for various organic transformations in fine chemical manufacturing. OYSI maintains reliable supply chains for bromobenzene, ensuring consistent availability for European industrial customers requiring this versatile aromatic halide for their synthetic and manufacturing processes.

Safety & Classification

Warning
Classification:

Flam. Liq. 3; Skin Irrit. 2; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H226

Flammable liquid and vapour.

H315

Causes skin irritation.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2514
ADR Class3
Packing GroupIII
Tunnel CodeD/E
Proper Shipping NameBrombenzen
Marine PollutantNo

Frequently Asked Questions

What is bromobenzene?

Bromobenzene is an aromatic halogenated hydrocarbon with the molecular formula C6H5Br and CAS number 108-86-1. It consists of a benzene ring with one bromine atom substituted for a hydrogen atom. With a molecular weight of 157.01 g/mol, bromobenzene appears as a colorless to pale yellow liquid with a characteristic aromatic odor. It is classified as a flammable liquid and requires careful handling due to its potential skin irritation properties and environmental impact.

What are the physicochemical properties of bromobenzene?

Bromobenzene is a colorless to pale yellow liquid at room temperature with a distinctive sweet, aromatic odor similar to benzene. It has a boiling point of approximately 156°C and a density higher than water. The compound is practically insoluble in water but readily soluble in organic solvents such as ethanol, ether, and acetone. It exhibits typical aromatic compound behavior and is stable under normal conditions but should be protected from strong oxidizing agents.

What is bromobenzene used for?

Bromobenzene is primarily used as an intermediate in organic synthesis for pharmaceutical and agrochemical manufacturing. It serves as a precursor for the production of various substituted aromatic compounds through nucleophilic substitution reactions. The compound is also utilized in the synthesis of dyes, perfumes, and other specialty chemicals. Additionally, bromobenzene finds application as a solvent in specific chemical processes and as a reagent in laboratory research for organic chemistry applications.

How to handle bromobenzene safely?

Bromobenzene requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under a fume hood to avoid inhalation of vapors. Keep away from ignition sources, heat, and sparks as it is classified as a flammable liquid. Avoid contact with skin and eyes, and ensure emergency wash facilities are readily available in the work area.

How to store bromobenzene correctly?

Bromobenzene should be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Use appropriate secondary containment and store in compatible containers, preferably original packaging. Keep away from strong oxidizing agents and incompatible materials. Storage areas should be equipped with appropriate fire suppression systems and spill control measures. Ensure containers are properly labeled and access is restricted to authorized personnel only.

What to do in case of contact with bromobenzene?

In case of skin contact with bromobenzene, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. If swallowed, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist or worsen.

How to dispose of bromobenzene appropriately?

Bromobenzene must be disposed of as hazardous waste in accordance with local, national, and international regulations. The compound cannot be discharged into sewers, waterways, or soil due to its environmental classification. Contact licensed waste disposal companies for proper collection and treatment. Small quantities may be incinerated at high temperatures in approved facilities. Always consult current waste disposal regulations and obtain proper waste codes before disposal.

How to transport bromobenzene?

Bromobenzene is classified under ADR as Class 3 (Flammable Liquids), Packing Group III for transportation purposes. It must be packaged in approved containers and properly labeled with appropriate hazard markings and documentation. Transport vehicles should be equipped with appropriate safety equipment and drivers must hold valid dangerous goods certifications. Shipping papers must accompany the shipment with correct technical names, UN numbers, and emergency contact information.

Is bromobenzene subject to specific regulations?

Bromobenzene is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification and labeling obligations. It is not currently listed as a Substance of Very High Concern (SVHC). The compound must be handled according to occupational safety regulations and environmental protection laws. Users must maintain safety data sheets, conduct risk assessments, and implement appropriate control measures. Import/export may require additional permits depending on destination countries.

Where to buy bromobenzene in Europe?

Bromobenzene is available through OYSI, a European distributor specializing in technical chemical products. As an established chemical supplier, OYSI can provide bromobenzene with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly for availability, specifications, packaging options, and delivery throughout Europe. Ensure your organization has the necessary permits and safety measures in place before ordering this regulated chemical substance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.