Benzo[a]pyrene

C20H12

benzo[a]pyrene

CAS50-32-8
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
50-32-8
EC Number
200-028-5
UN Number
3077
Index Number
601-032-00-3
PubChem CID
2336

Physical-chemical properties

Molecular Formula
C20H12
Molar Mass
252.30 g/mol
IUPAC Name
benzo[a]pyrene

Chemical Identifiers

InChI
InChI=1S/C20H12/c1-2-7-17-15(4-1)12-16-9-8-13-5-3-6-14-10-11-18(17)20(16)19(13)14/h1-12H
InChI Key
FMMWHPNWAFZXNH-UHFFFAOYSA-N

Overview

Benzo[a]pyrene (CAS 50-32-8) is a polycyclic aromatic hydrocarbon with significant carcinogenic properties and environmental persistence. This highly regulated chemical compound consists of five fused benzene rings, making it one of the most studied polycyclic aromatic hydrocarbons (PAHs) in industrial and environmental chemistry. Benzo[a]pyrene occurs naturally through incomplete combustion processes and is commonly found in coal tar, cigarette smoke, and grilled foods. Its molecular structure of C20H12 with a molecular weight of 252.3 g/mol gives it distinctive chemical stability and low volatility characteristics. The compound presents severe health hazards, classified as carcinogenic (Carc. 1B), mutagenic (Muta. 1B), and toxic to reproduction (Repr. 1B). It also acts as a skin sensitizer and poses significant aquatic toxicity risks, requiring careful handling with appropriate personal protective equipment and containment measures. The GHS08, GHS07, and GHS09 pictograms indicate its serious health and environmental hazards, necessitating specialized storage and transport under ADR Class 9 regulations. In industrial applications, benzo[a]pyrene serves primarily as an analytical standard in environmental monitoring laboratories for PAH contamination assessment. It is utilized in research facilities studying carcinogenesis mechanisms and metabolic pathways. Additionally, it functions as a reference compound in air quality monitoring systems and soil contamination analysis. Unlike simpler aromatic compounds such as diphenyldiazene, benzo[a]pyrene requires extensive safety protocols due to its complex ring structure and associated toxicity profile. OYSI provides high-purity benzo[a]pyrene with comprehensive documentation to support analytical and research applications across European markets.

Safety & Classification

Danger
Classification:

Carc. 1B; Muta. 1B; Repr. 1B; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H340

May cause genetic defects.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameBenzo[def]chrysen
Marine PollutantNo

Frequently Asked Questions

What is benzo[a]pyrene?

Benzo[a]pyrene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C20H12 and CAS number 50-32-8. This compound consists of five fused benzene rings and has a molecular weight of 252.3 g/mol. It is classified as a highly hazardous substance with carcinogenic, mutagenic, and reproductive toxicity properties, requiring careful handling and strict safety measures in industrial applications.

What are the physicochemical properties of benzo[a]pyrene?

Benzo[a]pyrene is a solid crystalline compound that appears as pale yellow crystals or powder at room temperature. It has very low water solubility but is soluble in organic solvents such as benzene, toluene, and acetone. The compound is odorless and exhibits strong fluorescence under UV light. It has a high melting point and low vapor pressure, making it relatively stable under normal conditions.

What is benzo[a]pyrene used for?

Benzo[a]pyrene is primarily used as a research chemical and analytical standard in environmental monitoring and toxicology studies. It serves as a reference compound for PAH analysis in environmental samples, food testing, and air quality assessments. In industrial settings, it may be used in specialized research applications and as a marker compound for combustion processes and pollution studies.

How to handle benzo[a]pyrene safely?

Benzo[a]pyrene requires strict safety measures due to its carcinogenic and mutagenic properties. Always wear appropriate personal protective equipment including nitrile gloves, safety goggles, and lab coats. Work in a well-ventilated area or fume hood to prevent inhalation. Avoid skin contact and ingestion completely. Use proper handling techniques to minimize dust formation and ensure all personnel are trained in hazardous chemical procedures.

How to store benzo[a]pyrene correctly?

Benzo[a]pyrene should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly sealed to prevent contamination and minimize exposure. Store in designated areas for carcinogenic substances with restricted access. Maintain storage temperature below 25°C and ensure compatibility with storage materials. Keep away from oxidizing agents and implement proper inventory management for hazardous chemicals.

What to do in case of contact with benzo[a]pyrene?

Benzo[a]pyrene exposure requires immediate action due to its toxic properties. For skin contact, immediately remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush with clean water for 15 minutes. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention immediately. Always consult a physician after any exposure.

How to dispose of benzo[a]pyrene appropriately?

Benzo[a]pyrene disposal must comply with hazardous waste regulations due to its carcinogenic properties. The substance should be collected in appropriate hazardous waste containers and disposed of through licensed hazardous waste disposal companies. Never dispose of in regular waste or pour down drains. Follow local and national regulations for carcinogenic waste disposal, maintain proper documentation, and ensure proper labeling of waste containers.

How to transport benzo[a]pyrene?

Benzo[a]pyrene is classified under ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation purposes. It must be packaged in appropriate containers that meet UN specifications and properly labeled with hazard markings. Transport documentation must include proper shipping names and hazard information. Carriers must be trained in handling dangerous goods and follow ADR regulations for safe transportation of hazardous materials.

Is benzo[a]pyrene subject to specific regulations?

Benzo[a]pyrene is subject to strict regulations under REACH and CLP regulations in Europe due to its classification as carcinogenic, mutagenic, and toxic to reproduction (CMR Category 1B). It requires safety data sheets, proper labeling with GHS pictograms (GHS07, GHS08, GHS09), and adherence to occupational exposure limits. Special authorization may be required for certain uses, and it falls under environmental monitoring requirements.

Where to buy benzo[a]pyrene in Europe?

Benzo[a]pyrene is available through specialized chemical distributors in Europe, including OYSI, which supplies high-quality research chemicals and analytical standards. Due to its hazardous nature, purchase is typically restricted to qualified laboratories and industrial users with proper safety protocols. Buyers must demonstrate appropriate handling capabilities and may need to provide end-use certificates. Contact authorized distributors for availability and regulatory compliance requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.