4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline

C15H18N2

CAS838-88-0
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
838-88-0
EC Number
212-658-8
UN Number
3077
Index Number
612-085-00-7
PubChem CID
13283

Physical-chemical properties

Molecular Formula
C15H18N2
Molar Mass
226.32 g/mol
IUPAC Name
4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline

Chemical Identifiers

InChI
InChI=1S/C15H18N2/c1-10-7-12(3-5-14(10)16)9-13-4-6-15(17)11(2)8-13/h3-8H,9,16-17H2,1-2H3
InChI Key
WECDUOXQLAIPQW-UHFFFAOYSA-N

Overview

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline (CAS 838-88-0) is an aromatic diamine compound with methylene bridge linkage between two substituted aniline rings. This chemical substance, also designated by EC number 212-658-8, belongs to the family of methylene dianilines (MDA) and serves as an important intermediate in various industrial chemical processes. With a molecular formula of C15H18N2 and molecular weight of 226.32 g/mol, this compound features two amino-substituted benzene rings connected by a methylene bridge, with additional methyl substituents that influence its reactivity and properties. The substance presents significant safety considerations and is classified under multiple hazard categories including carcinogenicity (Carc. 1B), acute toxicity (Acute Tox. 4), skin sensitization (Skin Sens. 1), and aquatic toxicity (Aquatic Acute 1, Aquatic Chronic 1). These classifications require careful handling protocols and appropriate safety measures during storage, transport, and use. The compound carries the signal word "Danger" and is associated with GHS pictograms GHS08, GHS07, and GHS09, reflecting its health hazards and environmental impact potential. In industrial applications, this aromatic diamine is primarily utilized in the production of polyurethane systems, epoxy curing agents, and as an intermediate in the synthesis of specialty polymers. It finds particular use in manufacturing high-performance materials where its unique chemical structure contributes to enhanced mechanical properties. The compound shares structural similarities with related substances such as 4-(4-amino-3-chlorophenyl)-2-chloroaniline, though the methyl substitution pattern provides distinct reactivity characteristics. OYSI maintains reliable supply capabilities for this specialty chemical intermediate, supporting European industrial customers with technical-grade material for approved applications.

Safety & Classification

Danger
Classification:

Carc. 1B; Acute Tox. 4 *; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H302

Harmful if swallowed.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping NameBis[4,4'-(3-Methylbenzenamin)]methan
Marine PollutantNo

Frequently Asked Questions

What is 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline is an aromatic diamine compound with the molecular formula C15H18N2 and CAS number 838-88-0. This organic chemical has a molecular weight of 226.32 g/mol and contains two amino groups attached to methylated benzene rings connected by a methylene bridge. It is classified as a Category 1B carcinogen and presents multiple hazards including acute toxicity, skin sensitization, and aquatic toxicity.

What are the physicochemical properties of 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline is a solid organic compound with a molecular weight of 226.32 g/mol. As an aromatic diamine, it typically appears as a crystalline solid that may darken upon exposure to air and light. The compound contains amino groups that make it moderately polar, affecting its solubility in various solvents. Its aromatic structure with methyl substituents influences its melting point and stability characteristics.

What is 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline used for?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline is primarily used as an intermediate in organic synthesis and chemical manufacturing. Its diamine structure makes it valuable for producing dyes, pigments, and polymer materials. The compound may also serve as a building block in pharmaceutical synthesis and specialty chemical production. However, due to its carcinogenic classification, its use is restricted and requires specialized handling procedures in industrial applications.

How to handle 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline safely?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline requires strict safety measures due to its carcinogenic and toxic properties. Essential PPE includes chemical-resistant gloves, safety goggles, and respiratory protection to prevent inhalation. Work must be conducted in well-ventilated areas or under fume hoods. Avoid skin contact and inhalation, as the substance can cause sensitization and acute toxicity. Only trained personnel should handle this material following established safety protocols.

How to store 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline correctly?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat and light sources. The storage area should be secure and restricted to authorized personnel due to its carcinogenic nature. Keep containers upright and protected from physical damage. Store separately from incompatible materials such as strong oxidizers and acids to prevent dangerous reactions.

What to do in case of contact with 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline?

Immediate action is required upon contact with 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately. For eye contact, rinse continuously with clean water for 15 minutes. Seek immediate medical attention in all cases of exposure, informing healthcare providers of the substance's carcinogenic properties and providing the safety data sheet.

How to dispose of 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline appropriately?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline disposal must comply with hazardous waste regulations due to its carcinogenic and environmentally hazardous classification. The substance requires disposal through licensed hazardous waste contractors authorized to handle carcinogenic materials. Incineration at high temperatures in approved facilities is typically required. Never dispose of in regular waste streams or discharge to sewers or environment. Contact local environmental authorities for specific disposal requirements and authorized waste management companies.

How to transport 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline is classified under ADR Class 9 (Miscellaneous dangerous goods) Packing Group III for transport. Packages must be properly labeled with appropriate hazard markings and UN identification numbers. Transport vehicles require appropriate placarding and documentation. Drivers must be trained in dangerous goods handling. The packaging must meet UN specifications and prevent leakage during normal transport conditions while protecting against environmental release.

Is 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline subject to specific regulations?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline is subject to comprehensive chemical regulations including REACH registration requirements and CLP classification as Carcinogen 1B. Although not currently listed as an SVHC, its carcinogenic properties may trigger future regulatory restrictions. Users must comply with occupational exposure limits and workplace safety regulations. Import, use, and disposal are regulated under various national and EU chemical safety frameworks requiring proper documentation and safety measures.

Where to buy 4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline in Europe?

4-[(4-amino-3-methylphenyl)methyl]-2-methylaniline is available through OYSI, a European distributor of specialty chemicals. As a regulated carcinogenic substance, procurement requires proper authorization and compliance with chemical safety regulations. OYSI provides technical support and regulatory guidance for professional users. Purchase is restricted to qualified industrial users with appropriate safety facilities and trained personnel. Contact OYSI directly for availability, specifications, and regulatory compliance requirements for your specific application.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.