Thionyl dichloride

Cl2OS

thionyl dichloride

CAS7719-09-7
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

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Identification

CAS Number
7719-09-7
EC Number
231-748-8
UN Number
1836
Index Number
016-015-00-0
PubChem CID
24386

Physical-chemical properties

Molecular Formula
Cl2OS
Molar Mass
118.97 g/mol
IUPAC Name
thionyl dichloride

Chemical Identifiers

InChI
InChI=1S/Cl2OS/c1-4(2)3
InChI Key
FYSNRJHAOHDILO-UHFFFAOYSA-N

Overview

Thionyl dichloride (CAS 7719-09-7) is an inorganic chlorinating agent with highly reactive properties and corrosive characteristics. This versatile chemical compound, with the molecular formula Cl2OS and molecular weight of 118.97 g/mol, serves as a crucial reagent in organic synthesis and industrial chemical processes. Thionyl dichloride appears as a colorless to pale yellow liquid that readily releases toxic gases upon contact with moisture, making it essential for anhydrous reaction conditions. Its classification under GHS pictograms GHS05 and GHS07 with the danger signal word reflects its corrosive nature and acute toxicity properties. The compound exhibits exceptional reactivity with alcohols and carboxylic acids, converting them efficiently to corresponding alkyl chlorides and acid chlorides respectively. This property makes it invaluable in pharmaceutical synthesis, where precise chlorination reactions are required. Unlike other chlorinating agents such as phenylmethanamine-based systems, thionyl dichloride offers the advantage of producing gaseous byproducts (SO2 and HCl) that can be easily removed from reaction mixtures. Primary industrial applications include the production of acid chlorides for pharmaceutical intermediates, the synthesis of organochlorine compounds, and as a dehydrating agent in chemical manufacturing processes. The compound finds extensive use in the preparation of specialty chemicals where anhydrous conditions are paramount. Safety considerations are critical when handling thionyl dichloride, as it falls under ADR Class 8 (corrosive substances) and exhibits Skin Corr. 1A and Acute Tox. 4 classifications. Proper ventilation, appropriate personal protective equipment, and moisture-free storage conditions are mandatory. OYSI provides technical-grade thionyl dichloride to meet diverse industrial requirements across European markets.

Safety & Classification

Danger
Classification:

Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1A

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H332

Harmful if inhaled.

H302

Harmful if swallowed.

H314

Causes severe skin burns and eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1836
ADR Class8
Packing GroupI
Tunnel CodeE
Proper Shipping NameThionylchlorid
Marine PollutantNo

Frequently Asked Questions

What is thionyl dichloride?

Thionyl dichloride is an inorganic compound with the chemical formula Cl2OS and CAS number 7719-09-7. This chemical substance has a molecular weight of 118.97 g/mol and belongs to the class of acid chlorides. It is classified as a corrosive substance with acute toxicity properties, requiring careful handling in industrial and laboratory applications. Thionyl dichloride is widely recognized for its strong reactivity and utility in various chemical synthesis processes.

What are the physicochemical properties of thionyl dichloride?

Thionyl dichloride is a colorless to pale yellow liquid at room temperature with a pungent, irritating odor. It has a boiling point of approximately 76°C and decomposes in the presence of moisture, releasing hydrogen chloride and sulfur dioxide gases. The compound is highly reactive with water and alcohols, making it moisture-sensitive. It is soluble in organic solvents but reacts violently with water, requiring anhydrous storage conditions.

What is thionyl dichloride used for?

Thionyl dichloride is primarily used as a chlorinating agent in organic synthesis, converting alcohols to alkyl chlorides and carboxylic acids to acyl chlorides. It serves as an important reagent in pharmaceutical manufacturing, pesticide production, and fine chemical synthesis. The compound is also utilized in the preparation of organosulfur compounds and as a dehydrating agent in various chemical processes, making it valuable in research and industrial applications.

How to handle thionyl dichloride safely?

Thionyl dichloride must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its corrosive properties. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation of vapors. Given its Acute Tox. 4 and Skin Corr. 1A classifications, operators must follow strict safety protocols and ensure emergency procedures are readily available.

How to store thionyl dichloride correctly?

Thionyl dichloride must be stored in tightly sealed, moisture-proof containers away from water and humidity sources. Storage areas should be cool, dry, and well-ventilated, separated from incompatible materials such as alcohols, amines, and water. The containers should be made of compatible materials and stored in secondary containment systems. Regular inspection of storage conditions and container integrity is essential to prevent accidental releases or decomposition.

What to do in case of contact with thionyl dichloride?

Immediate action is required in case of contact with thionyl dichloride due to its corrosive nature. For skin contact, remove contaminated clothing and flush the affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move the person to fresh air and provide respiratory support if needed. Always seek professional medical assistance promptly.

How to dispose of thionyl dichloride appropriately?

Thionyl dichloride waste must be disposed of according to local and international hazardous waste regulations. The compound should never be poured down drains or disposed of with regular waste due to its corrosive and toxic properties. Proper disposal typically involves neutralization by qualified waste management companies or incineration in specialized facilities. Always consult local environmental authorities and follow established hazardous waste disposal protocols.

How to transport thionyl dichloride?

Thionyl dichloride is classified under ADR Class 8 (corrosive substances), Packing Group I, indicating high danger level for transportation. It must be packaged in UN-approved containers and labeled with appropriate hazard symbols including GHS05 and GHS07 pictograms. Transportation requires proper documentation, trained personnel, and compliance with international dangerous goods regulations. Emergency response procedures must be available during transport.

Is thionyl dichloride subject to specific regulations?

Thionyl dichloride is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification obligations. While not listed as an SVHC (Substance of Very High Concern), it must comply with workplace safety regulations due to its corrosive and toxic properties. Users must follow proper labeling with 'Danger' signal words and appropriate pictograms, ensuring compliance with occupational health and safety standards.

Where to buy thionyl dichloride in Europe?

Thionyl dichloride is available through OYSI, a European distributor of technical chemicals specializing in industrial and laboratory-grade chemical products. As an established chemical supplier, OYSI provides quality thionyl dichloride with proper documentation and regulatory compliance for European markets. Contact OYSI directly for availability, technical specifications, and delivery options to meet your specific industrial or research requirements while ensuring full regulatory compliance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.