Benzoyl chloride
C7H5ClO
benzoyl chloride
Consulting for Benzoyl chloride
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Identification
- CAS Number
- 98-88-4
- EC Number
- 202-710-8
- UN Number
- 1736
- Index Number
- 607-012-00-0
- PubChem CID
- 7412
Physical-chemical properties
- Molecular Formula
- C7H5ClO
- Molar Mass
- 140.56 g/mol
- IUPAC Name
- benzoyl chloride
Chemical Identifiers
- InChI
- InChI=1S/C7H5ClO/c8-7(9)6-4-2-1-3-5-6/h1-5H
- InChI Key
- PASDCCFISLVPSO-UHFFFAOYSA-N
Overview
Benzoyl chloride (CAS 98-88-4) is an aromatic acyl chloride featuring high reactivity and corrosive properties essential for organic synthesis applications. This colorless to slightly yellow liquid represents one of the most important acyl chlorides in industrial chemistry, serving as a versatile intermediate for numerous chemical transformations. With the molecular formula C7H5ClO and a molecular weight of 140.56 g/mol, benzoyl chloride exhibits characteristic properties of acid chlorides, including rapid hydrolysis in the presence of moisture and strong electrophilic behavior. The compound releases hydrogen chloride gas upon contact with water, making proper handling procedures essential for safe operations. The substance presents significant safety considerations, classified under multiple hazard categories including acute toxicity, skin corrosion, and skin sensitization. Its corrosive nature requires appropriate personal protective equipment and controlled storage conditions to prevent exposure. Like other reactive intermediates such as phenylmethanamine, benzoyl chloride demands careful handling protocols due to its potential health impacts. Industrial applications primarily focus on pharmaceutical synthesis, where benzoyl chloride serves as an acylating agent for producing various drug intermediates. The dye industry utilizes this compound for manufacturing colorants and pigments, while polymer chemistry employs it in the production of specialized resins and plastics. Additionally, benzoyl chloride functions as a precursor for benzoyl peroxide, widely used as a polymerization initiator and in pharmaceutical applications. The compound's reactivity profile makes it valuable for Friedel-Crafts acylation reactions and other organic transformations requiring selective acylation. Its compatibility with various catalytic systems allows for precise control in synthetic processes. OYSI maintains reliable supply chains for benzoyl chloride, ensuring consistent availability for European industrial customers requiring this essential chemical intermediate.
Safety & Classification
Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1736 |
| ADR Class | 8 |
| Packing Group | II |
| Tunnel Code | E |
| Proper Shipping Name | Benzoylchlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is benzoyl chloride?
Benzoyl chloride is an organic compound with the chemical formula C7H5ClO and CAS number 98-88-4. It belongs to the acyl chloride family and has a molecular weight of 140.56 g/mol. This substance is classified as corrosive and toxic, requiring careful handling in industrial applications. It serves as an important intermediate in organic synthesis and chemical manufacturing processes.
What are the physicochemical properties of benzoyl chloride?
Benzoyl chloride is a colorless to slightly yellow liquid at room temperature with a characteristic pungent, irritating odor. It has a boiling point of approximately 197°C and is sensitive to moisture, readily hydrolyzing in water to form benzoic acid and hydrochloric acid. The compound is soluble in organic solvents like benzene, ether, and chloroform but reacts violently with water and alcohols.
What is benzoyl chloride used for?
Benzoyl chloride is primarily used as an intermediate in organic synthesis for producing pharmaceuticals, dyes, perfumes, and resins. It serves as a benzoylating agent in the manufacture of benzoyl peroxide, used in plastics and cosmetics. The compound is also employed in the production of benzophenone derivatives, pharmaceutical intermediates, and various specialty chemicals in industrial applications.
How to handle benzoyl chloride safely?
Benzoyl chloride requires strict safety measures due to its corrosive and toxic nature. Personnel must wear full protective equipment including chemical-resistant gloves, safety goggles, face shields, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods. Avoid contact with skin, eyes, and respiratory system. Keep away from moisture and incompatible materials during handling operations.
How to store benzoyl chloride correctly?
Benzoyl chloride must be stored in tightly sealed, dry containers away from moisture, heat, and ignition sources. Storage areas should be cool, well-ventilated, and equipped with appropriate containment systems. Keep separated from water, alcohols, bases, and oxidizing agents to prevent dangerous reactions. Use corrosion-resistant materials for storage containers and ensure proper labeling according to GHS requirements.
What to do in case of contact with benzoyl chloride?
Immediate action is required for benzoyl chloride contact due to its corrosive properties. For skin contact, remove contaminated clothing and flush affected areas with plenty of water for at least 15 minutes. In case of eye contact, rinse immediately with water and seek medical attention. If inhaled, move to fresh air and get medical help. Never induce vomiting if ingested.
How to dispose of benzoyl chloride appropriately?
Benzoyl chloride disposal must comply with local and European waste regulations as hazardous chemical waste. The substance cannot be disposed of through regular waste streams due to its corrosive and toxic properties. Contact licensed hazardous waste disposal companies for proper treatment. Small quantities can be neutralized carefully with appropriate bases under controlled conditions by trained personnel only.
How to transport benzoyl chloride?
Benzoyl chloride is classified under ADR as Class 8 (corrosive substances), Packing Group II, indicating high transport risk. Transportation requires proper UN-approved packaging, appropriate labeling with GHS05 and GHS07 pictograms, and compliance with dangerous goods regulations. Vehicles must carry proper documentation, emergency procedures, and trained personnel familiar with handling corrosive materials during transport operations.
Is benzoyl chloride subject to specific regulations?
Benzoyl chloride is regulated under European REACH and CLP regulations due to its hazardous properties. It carries the signal word 'Danger' and is classified for acute toxicity, skin corrosion, and skin sensitization. The substance is not listed as SVHC (Substance of Very High Concern). Users must comply with safety data sheet requirements, worker protection measures, and proper classification and labeling standards.
Where to buy benzoyl chloride in Europe?
Benzoyl chloride is available through OYSI, a European distributor specializing in technical chemical products. As an established chemical supplier, OYSI provides quality benzoyl chloride with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly for availability, technical specifications, packaging options, and delivery throughout Europe while ensuring all regulatory requirements are met.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.