2-chloro-6-fluorophenol
C6H4ClFO
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Identification
- CAS Number
- 2040-90-6
- EC Number
- 433-890-8
- UN Number
- 3261
- Index Number
- 604-082-00-4
- PubChem CID
- 2773710
Physical-chemical properties
- Molecular Formula
- C6H4ClFO
- Molar Mass
- 146.54 g/mol
- IUPAC Name
- 2-chloro-6-fluorophenol
Chemical Identifiers
- InChI
- InChI=1S/C6H4ClFO/c7-4-2-1-3-5(8)6(4)9/h1-3,9H
- InChI Key
- QIAQIYQASAWZPP-UHFFFAOYSA-N
Overview
2-chloro-6-fluorophenol (CAS 2040-90-6) is a halogenated phenolic compound with dual halogen substitution on the benzene ring. This specialized aromatic compound represents an important class of halogenated phenols used in various industrial applications. With its molecular formula C6H4ClFO and molecular weight of 146.54 g/mol, 2-chloro-6-fluorophenol features both chlorine and fluorine substituents positioned ortho to the hydroxyl group, creating unique chemical properties that distinguish it from other phenolic derivatives. The compound's classification under multiple hazard categories, including mutagenic (Muta. 1B), reproductive toxicity (Repr. 2), and skin corrosion (Skin Corr. 1B), necessitates strict handling protocols and appropriate safety measures. The ADR Class 8 designation reflects its corrosive nature, while the GHS pictograms (GHS08, GHS07, GHS05, GHS09) indicate serious health hazards, corrosive effects, and environmental concerns requiring specialized storage and transportation procedures. Primary industrial applications include use as a chemical intermediate in pharmaceutical synthesis, agrochemical production, and specialty chemical manufacturing. The dual halogenation pattern makes it particularly valuable in the development of bioactive compounds where specific electronic and steric properties are required. Unlike simpler compounds such as (Z)-octadec-9-en-1-amine, the halogenated aromatic structure of 2-chloro-6-fluorophenol provides enhanced reactivity for nucleophilic aromatic substitution reactions. The compound's aquatic chronic toxicity classification emphasizes the importance of proper waste management and environmental protection measures during handling and processing operations. OYSI maintains reliable supply chains for 2-chloro-6-fluorophenol, supporting European customers with comprehensive technical documentation and regulatory compliance assistance.
Safety & Classification
Muta. 1B; Repr. 2; Acute Tox. 4 *; Skin Corr. 1B; Skin Sens. 1; Aquatic Chronic 2
GHS Pictograms
Health Hazard
GHS08
Serious health hazard. May cause cancer, organ damage, or genetic defects.
Exclamation Mark
GHS07
Harmful. May cause irritation, allergic reactions, or drowsiness.
Corrosion
GHS05
Corrosive. Causes severe skin burns and eye damage.
Environment
GHS09
Environmental hazard. Toxic to aquatic life with long lasting effects.
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 3261 |
| ADR Class | 8 |
| Packing Group | II |
| Tunnel Code | E |
| Proper Shipping Name | 2-Chlor-6-fluorphenol |
| Marine Pollutant | No |
Frequently Asked Questions
What is 2-chloro-6-fluorophenol?
2-chloro-6-fluorophenol is an organohalogen compound with the molecular formula C6H4ClFO and CAS number 2040-90-6. This chemical features a phenol ring substituted with both chlorine and fluorine atoms at specific positions. With a molecular weight of 146.54 g/mol, it is classified as a hazardous substance requiring careful handling due to its mutagenic, reproductive, and corrosive properties.
What are the physicochemical properties of 2-chloro-6-fluorophenol?
2-chloro-6-fluorophenol is typically a solid crystalline compound at room temperature with characteristic halogenated phenol properties. The presence of both chlorine and fluorine substituents influences its polarity, solubility characteristics, and chemical reactivity. Its molecular structure confers specific melting and boiling points, and it exhibits phenolic chemical behavior with enhanced stability due to halogen substitution.
What is 2-chloro-6-fluorophenol used for?
2-chloro-6-fluorophenol serves primarily as an intermediate in pharmaceutical and agrochemical synthesis. Its halogenated phenolic structure makes it valuable for manufacturing complex organic molecules, particularly in the development of specialized pharmaceuticals, pesticides, and other fine chemicals. The compound's unique substitution pattern provides specific reactivity that is exploited in advanced organic synthesis applications.
How to handle 2-chloro-6-fluorophenol safely?
2-chloro-6-fluorophenol requires stringent safety measures due to its corrosive and sensitizing properties. Essential protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing. Work must be conducted in well-ventilated areas or under fume hoods. Avoid skin contact and inhalation, as the substance can cause severe burns and allergic reactions. Emergency shower and eyewash facilities should be readily accessible.
How to store 2-chloro-6-fluorophenol correctly?
2-chloro-6-fluorophenol must be stored in tightly sealed, chemically compatible containers in a cool, dry, well-ventilated area away from incompatible materials. Storage areas should be equipped with appropriate containment measures and kept away from heat sources and direct sunlight. Due to its corrosive nature, use containers made of suitable materials and ensure proper segregation from other chemical classes.
What to do in case of contact with 2-chloro-6-fluorophenol?
Immediate action is critical upon contact with 2-chloro-6-fluorophenol due to its corrosive properties. For skin contact, immediately flush with copious amounts of water for at least 15 minutes and remove contaminated clothing. For eye contact, rinse thoroughly with water. If inhaled, move to fresh air. Seek immediate medical attention in all cases of exposure, as the substance can cause severe burns and systemic effects.
How to dispose of 2-chloro-6-fluorophenol appropriately?
2-chloro-6-fluorophenol disposal must comply with local and international hazardous waste regulations due to its classification as dangerous goods. The substance requires treatment at authorized hazardous waste facilities equipped to handle corrosive and potentially mutagenic materials. Never dispose of in regular waste streams or pour down drains. Contact certified waste management companies for proper collection, treatment, and disposal according to regulatory requirements.
How to transport 2-chloro-6-fluorophenol?
2-chloro-6-fluorophenol is classified as ADR Class 8 (corrosive substances), Packing Group II, requiring specialized transport procedures. Packages must meet UN specification standards for corrosive materials and display appropriate hazard labels and markings. Transport vehicles need proper documentation, emergency response information, and drivers must have adequate dangerous goods training. Only authorized carriers should handle the shipment.
Is 2-chloro-6-fluorophenol subject to specific regulations?
2-chloro-6-fluorophenol is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification obligations. Its classification as Muta. 1B and Repr. 2 places it under strict regulatory oversight. While not currently listed as an SVHC, its hazard profile requires compliance with occupational safety regulations, transportation rules, and environmental protection measures across different jurisdictions.
Where to buy 2-chloro-6-fluorophenol in Europe?
2-chloro-6-fluorophenol is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI can provide this regulated substance to qualified industrial customers with proper documentation and regulatory compliance. Contact OYSI directly to discuss availability, technical specifications, regulatory requirements, and delivery options for your specific application needs.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.