Propan-2-amine
C3H9N
propan-2-amine
Consulting for Propan-2-amine
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Identification
- CAS Number
- 75-31-0
- EC Number
- 200-860-9
- UN Number
- 1221
- Index Number
- 612-007-00-1
- PubChem CID
- 6363
Physical-chemical properties
- Molecular Formula
- C3H9N
- Molar Mass
- 59.11 g/mol
- IUPAC Name
- propan-2-amine
Chemical Identifiers
- InChI
- InChI=1S/C3H9N/c1-3(2)4/h3H,4H2,1-2H3
- InChI Key
- JJWLVOIRVHMVIS-UHFFFAOYSA-N
Overview
Propan-2-amine (CAS 75-31-0) is a primary aliphatic amine with flammable properties and moderate toxicity profile. This branched primary amine, also known as isopropylamine, represents an important building block in organic synthesis and industrial chemistry. With its molecular formula C3H9N and molecular weight of 59.11 g/mol, propan-2-amine exhibits typical characteristics of short-chain aliphatic amines, including high reactivity and strong basicity. The compound appears as a colorless liquid with a characteristic ammonia-like odor and demonstrates significant volatility at ambient temperatures. From a safety perspective, propan-2-amine requires careful handling due to its classification as a Category 1 flammable liquid, presenting substantial fire and explosion hazards. The substance can cause skin and eye irritation (Category 2) and may cause specific target organ toxicity following single exposure (STOT SE 3), particularly affecting the respiratory system. The GHS02 flame pictogram and GHS07 exclamation mark pictogram, along with the "Danger" signal word, emphasize the need for appropriate personal protective equipment and ventilation systems during handling. Industrial applications of propan-2-amine span multiple sectors, primarily as an intermediate in pharmaceutical synthesis where it serves as a precursor for various active pharmaceutical ingredients. The chemical industry utilizes this amine in the production of pesticides and herbicides, while it also functions as a catalyst and pH modifier in specialized chemical processes. Unlike related aromatic compounds such as ethylbenzene and styrene, propan-2-amine's aliphatic structure provides distinct reactivity patterns particularly valuable in nucleophilic substitution reactions. OYSI maintains reliable supply chains for propan-2-amine, ensuring consistent availability for European industrial customers requiring this versatile amine intermediate.
Safety & Classification
Flam. Liq. 1; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1221 |
| ADR Class | 3 |
| Packing Group | I |
| Tunnel Code | C/E |
| Proper Shipping Name | Isopropylamin |
| Marine Pollutant | No |
Frequently Asked Questions
What is propan-2-amine?
Propan-2-amine is an organic compound belonging to the primary amine family with the molecular formula C3H9N and CAS number 75-31-0. This chemical features an amino group (-NH2) attached to the second carbon of a propane chain, giving it its characteristic structure. With a molecular weight of 59.11 g/mol, propan-2-amine is classified as a highly flammable liquid that poses skin and eye irritation risks, requiring careful handling in industrial applications.
What are the physicochemical properties of propan-2-amine?
Propan-2-amine is a colorless liquid with a strong ammonia-like odor characteristic of primary amines. It has a relatively low molecular weight of 59.11 g/mol and demonstrates high volatility and flammability. The compound is highly soluble in water due to hydrogen bonding between the amino group and water molecules. Its basic nature allows it to form salts with acids, and it readily evaporates at room temperature, contributing to its flammable vapor formation.
What is propan-2-amine used for?
Propan-2-amine serves as a versatile intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of pesticides, herbicides, and various pharmaceutical compounds. The compound also functions as a building block for specialty chemicals and serves as a catalyst or reagent in chemical reactions. Additionally, it finds application in the synthesis of surfactants and corrosion inhibitors for industrial processes.
How to handle propan-2-amine safely?
Propan-2-amine requires strict safety measures due to its highly flammable nature and irritant properties. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to prevent vapor accumulation. Keep away from heat sources, sparks, and open flames. Use non-sparking tools and ensure proper grounding of equipment. Avoid skin and eye contact, and have emergency shower facilities readily available.
How to store propan-2-amine correctly?
Propan-2-amine must be stored in cool, dry, well-ventilated areas away from heat sources and ignition points. Use approved flammable liquid storage cabinets and ensure containers are tightly sealed to prevent vapor escape. Keep away from oxidizing agents, acids, and incompatible materials. Storage areas should have appropriate fire suppression systems and spill containment measures. Maintain temperatures below 25°C and protect from direct sunlight to prevent pressure buildup in containers.
What to do in case of contact with propan-2-amine?
Immediate action is crucial following propan-2-amine exposure. For skin contact, remove contaminated clothing and flush the affected area with plenty of water for at least 15 minutes. In case of eye contact, rinse immediately with water for 15 minutes while holding eyelids open. If inhaled, move the person to fresh air and seek medical attention if breathing difficulties occur. For ingestion, do not induce vomiting and seek immediate medical help while rinsing the mouth with water.
How to dispose of propan-2-amine properly?
Propan-2-amine disposal must comply with local and European waste regulations as a hazardous chemical waste. Never pour down drains or into the environment due to its flammable and irritant properties. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small quantities can be neutralized under controlled conditions by qualified personnel. All containers should be properly labeled and segregated from other waste streams before disposal through authorized channels.
How to transport propan-2-amine?
Propan-2-amine is classified under ADR Class 3 (Flammable Liquids) Packing Group I, indicating high danger level during transport. Shipments require UN-approved packaging, proper labeling with GHS02 and GHS07 pictograms, and dangerous goods documentation. Vehicles must carry appropriate fire extinguishers and spill kits. Drivers need hazardous materials training certification. Transport should avoid extreme temperatures and ensure packages remain upright and secure to prevent leakage during transit.
Is propan-2-amine subject to specific regulations?
Propan-2-amine is regulated under European REACH regulation and must comply with CLP classification requirements. It carries the signal word 'Danger' with classifications including Flam. Liq. 1, STOT SE 3, Skin Irrit. 2, and Eye Irrit. 2. The substance is not currently listed as SVHC under REACH. Companies handling this chemical must ensure proper safety data sheets, worker training, and compliance with occupational exposure limits as defined by national authorities.
Where to buy propan-2-amine in Europe?
Propan-2-amine is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across the continent. OYSI provides reliable supply chains, proper documentation, and technical support for businesses requiring this flammable chemical intermediate. As an established chemical distributor, OYSI ensures compliance with European regulations including REACH registration and proper hazardous materials handling procedures for safe delivery to qualified industrial users.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.