Oxolane

Oxolane is a cyclic ether with the molecular formula C4H8O and CAS number 109-99-9. Also known as tetrahydrofuran (THF), it is a heterocyclic organic compound featuring a five-membered ring containing four carbon atoms and one oxygen atom. With a molecular weight of 72.11 g/mol, oxolane is classified as a flammable liquid and potential carcinogen, requiring careful handling in industrial applications.

Oxolane is a colorless, volatile liquid with a characteristic ethereal odor at room temperature. It has excellent solvent properties and is miscible with water and most organic solvents. The compound exhibits low viscosity and high volatility, making it an effective aprotic solvent. Its cyclic structure provides stability while maintaining reactivity, and it readily dissolves both polar and nonpolar compounds, making it valuable in various chemical processes.

Oxolane serves primarily as a versatile aprotic solvent in pharmaceutical synthesis, polymer production, and chemical manufacturing. It is extensively used in the production of polyurethanes, as a reaction medium for organometallic chemistry, and in the synthesis of fine chemicals. The compound also functions as a starting material for various chemical intermediates and plays a crucial role in lithium battery electrolyte formulations and advanced material processing.

Oxolane requires strict safety protocols due to its flammable and potentially carcinogenic properties. Use appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Eliminate ignition sources, use explosion-proof equipment, and ground all containers during transfer. Work in fume hoods when possible, avoid skin and eye contact, and ensure emergency shower and eyewash stations are readily accessible.

Oxolane must be stored in tightly sealed containers in cool, dry, well-ventilated areas away from heat sources and ignition points. Keep containers in secondary containment and separate from strong oxidizing agents, acids, and bases. Storage areas should be equipped with appropriate fire suppression systems and maintained below recommended temperature limits. Use inert gas blanketing when necessary to prevent oxidation and peroxide formation over time.

Oxolane contact requires immediate action depending on exposure route. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush thoroughly with water and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical care. Always consult safety data sheets and contact poison control when necessary.

Oxolane disposal must comply with local, national, and European waste regulations as hazardous waste. The substance cannot be disposed of in regular drains or municipal waste systems. Arrange disposal through licensed hazardous waste contractors who can handle flammable and potentially carcinogenic materials. Consider recovery and recycling options when feasible, and maintain proper documentation of all disposal activities as required by regulatory authorities.

Oxolane is classified under ADR as Class 3 (flammable liquids), Packing Group II, requiring specific transport regulations. Use UN-approved packaging and ensure proper labeling with appropriate hazard markings and transport documents. Vehicles must comply with ADR requirements for flammable liquids, including proper ventilation, fire extinguishing equipment, and driver certification. Avoid transport during extreme temperatures and ensure emergency response information accompanies shipments.

Oxolane is regulated under European REACH and CLP regulations, requiring registration and classification as a flammable liquid and Category 2 carcinogen. The substance must be labeled with danger signals and appropriate GHS pictograms (GHS02, GHS08, GHS07). While not currently listed as an SVHC, it requires workplace exposure monitoring and risk assessments. Specific occupational exposure limits and safety measures must be implemented according to national legislation.

Oxolane is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across the continent. As an established chemical supplier, OYSI provides quality oxolane with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly for specific grades, quantities, and technical specifications to meet your industrial requirements while ensuring full regulatory compliance and safe handling procedures.