Oxolane

Oxolane is a heterocyclic organic compound with the molecular formula C4H8O and CAS number 109-99-9. Also known as tetrahydrofuran (THF), it is a five-membered ring ether with a molecular weight of 72.11 g/mol. This colorless, volatile liquid is classified as a flammable liquid and potential carcinogen, requiring careful handling in industrial applications.

Oxolane is a colorless, volatile liquid with a characteristic ether-like odor at room temperature. It has excellent solvent properties and is miscible with water and most organic solvents. The compound has a low boiling point and high vapor pressure, contributing to its flammability. Its cyclic ether structure makes it highly polar and reactive, particularly prone to peroxide formation upon exposure to air.

Oxolane serves primarily as a versatile aprotic solvent in chemical synthesis and industrial processes. It is extensively used in pharmaceutical manufacturing, polymer production (particularly for polyurethanes), and as a reaction medium for organometallic chemistry. Additionally, it functions as a solvent for resins, varnishes, and adhesives, and plays a crucial role in lithium battery electrolyte formulations and extraction processes.

Oxolane requires strict safety measures due to its flammable and carcinogenic properties. Use appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Eliminate all ignition sources and work away from heat, sparks, and flames. Implement proper grounding procedures to prevent static electricity buildup and ensure emergency eyewash stations are readily available.

Oxolane must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed and protected from light to prevent peroxide formation. Store separately from oxidizing agents, acids, and bases. Use appropriate secondary containment and ensure storage areas are equipped with fire suppression systems. Regular testing for peroxide formation is recommended for long-term storage.

Immediate first aid measures are essential upon oxolane contact. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water for 15-20 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical assistance.

Oxolane disposal must comply with local and international waste regulations as hazardous chemical waste. The substance cannot be disposed of through regular waste streams due to its flammable and carcinogenic classification. Contact licensed hazardous waste disposal companies for proper treatment, which typically involves high-temperature incineration in authorized facilities. Always consult local environmental authorities for specific disposal requirements and documentation procedures.

Oxolane is classified under ADR as Class 3 (Flammable Liquids), Packing Group II, requiring specialized transportation procedures. Use UN-approved packaging and ensure proper labeling with hazard diamonds and transport documentation. Vehicles must be equipped with appropriate fire extinguishers and emergency equipment. Drivers require ADR certification, and transport routes should avoid populated areas where possible. Ensure proper loading and securing procedures are followed.

Oxolane is regulated under multiple European frameworks including REACH and CLP regulations due to its carcinogenic classification (Carc. 2). It requires safety data sheets and risk assessments for industrial use. The substance is subject to workplace exposure limits and requires notification for certain uses. Companies handling oxolane must implement appropriate risk management measures and may need authorization for specific applications under REACH.

Oxolane is available through OYSI, a trusted European distributor of technical chemicals. OYSI provides high-quality oxolane with proper documentation, safety data sheets, and regulatory compliance support across European markets. As a specialized chemical distributor, OYSI ensures reliable supply chains and technical expertise for industrial customers requiring this important solvent for their manufacturing processes and research applications.