Chloromethylbenzene

C7H7Cl

chloromethylbenzene

CAS100-44-7
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
Danger

Consulting for Chloromethylbenzene

Our experts support you with application, dosage, and compliance.

Request Consultation

Identification

CAS Number
100-44-7
EC Number
202-853-6
UN Number
1738
Index Number
602-037-00-3
PubChem CID
7503

Physical-chemical properties

Molecular Formula
C7H7Cl
Molar Mass
126.58 g/mol
IUPAC Name
chloromethylbenzene

Chemical Identifiers

InChI
InChI=1S/C7H7Cl/c8-6-7-4-2-1-3-5-7/h1-5H,6H2
InChI Key
KCXMKQUNVWSEMD-UHFFFAOYSA-N

Overview

Chloromethylbenzene (CAS 100-44-7) is an aromatic organochlorine compound with significant industrial applications and notable carcinogenic properties. This chemical substance, also known by its IUPAC designation chloromethylbenzene, represents a critical intermediate in organic synthesis and industrial manufacturing processes. With the molecular formula C7H7Cl and a molecular weight of 126.58 g/mol, this compound features a benzene ring substituted with a chloromethyl group, making it a versatile building block for various chemical transformations. The European registration number EC 202-853-6 confirms its established presence in industrial applications across multiple sectors. The substance carries significant safety considerations, classified under multiple hazard categories including carcinogenicity (Carc. 1B), acute toxicity, and organ toxicity. The GHS08, GHS06, and GHS05 pictograms indicate serious health hazards, corrosive properties, and toxic effects, requiring strict handling protocols and specialized safety equipment. Its ADR classification of 6.1 designates it as a toxic substance for transportation purposes, necessitating appropriate shipping and storage procedures. Industrial applications primarily focus on pharmaceutical intermediates, polymer synthesis, and specialty chemical manufacturing. The compound serves as a key precursor in the production of various benzyl derivatives and finds use in the synthesis of active pharmaceutical ingredients. Its reactivity profile makes it valuable in processes requiring electrophilic substitution reactions, similar to other reactive intermediates like 1-chloro-4-isocyanatobenzene in specialized applications. OYSI maintains professional-grade chloromethylbenzene supplies to support European industrial operations, ensuring compliance with regional chemical regulations and quality standards.

Safety & Classification

Danger
Classification:

Carc. 1B; Acute Tox. 3 *; Acute Tox. 4 *; STOT SE 3; STOT RE 2 *; Skin Irrit. 2; Eye Dam. 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H331

Toxic if inhaled.

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H373

May cause damage to organs through prolonged or repeated exposure.

H315

Causes skin irritation.

H318

Causes serious eye damage.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1738
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameBenzylchlorid
Marine PollutantNo

Frequently Asked Questions

What is chloromethylbenzene?

Chloromethylbenzene is an aromatic organochlorine compound with the molecular formula C7H7Cl and CAS number 100-44-7. This chemical substance has a molecular weight of 126.58 g/mol and belongs to the family of chlorinated toluenes. It is classified as a highly hazardous substance with carcinogenic properties (Category 1B) and multiple toxicity concerns. The compound exhibits acute toxicity, skin and eye irritation potential, and can cause specific target organ toxicity upon single and repeated exposure.

What are the physicochemical properties of chloromethylbenzene?

Chloromethylbenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. The compound has limited solubility in water but dissolves readily in organic solvents such as alcohols, ethers, and hydrocarbons. It has a relatively high vapor pressure, making it volatile under normal conditions. The substance is stable under normal storage conditions but may decompose upon heating or in the presence of strong bases or acids, potentially releasing toxic chlorine-containing compounds.

What is chloromethylbenzene used for?

Chloromethylbenzene serves primarily as an important chemical intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of various chemicals including pharmaceuticals, agrochemicals, and specialty chemicals. The compound acts as an alkylating agent in chemical reactions and is utilized in the synthesis of quaternary ammonium compounds, surfactants, and polymer additives. Due to its carcinogenic classification, its use is strictly regulated and limited to professional industrial applications with appropriate safety measures.

How to handle chloromethylbenzene safely?

Chloromethylbenzene requires strict safety protocols due to its carcinogenic and toxic properties. Personnel must wear full personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection with appropriate filters. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Skin contact must be avoided completely, and emergency shower facilities should be readily available. Only trained personnel should handle this substance, and exposure monitoring may be required depending on local regulations and workplace policies.

How to store chloromethylbenzene correctly?

Chloromethylbenzene must be stored in tightly sealed, chemically compatible containers in a cool, dry, and well-ventilated area away from heat sources and direct sunlight. The storage area should be equipped with appropriate containment systems and fire suppression equipment. Keep away from strong bases, acids, and oxidizing agents to prevent dangerous reactions. Storage facilities must comply with local hazardous material regulations, and access should be restricted to authorized personnel only. Regular inspection of containers for leaks or deterioration is essential.

What to do in case of contact with chloromethylbenzene?

Immediate action is required upon contact with chloromethylbenzene. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and provide respiratory support if needed. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult emergency services and provide the safety data sheet to medical personnel.

How to dispose of chloromethylbenzene appropriately?

Chloromethylbenzene disposal must comply with local and national hazardous waste regulations due to its carcinogenic classification. The substance cannot be disposed of through regular waste streams and requires specialized hazardous waste treatment. Contact licensed hazardous waste disposal companies for proper collection and destruction, typically through high-temperature incineration at authorized facilities. Never discharge into sewers, waterways, or soil. Maintain proper documentation of disposal activities and ensure compliance with waste tracking requirements. Empty containers may also require special handling as hazardous waste.

How to transport chloromethylbenzene?

Chloromethylbenzene is classified under ADR as Class 6.1 (Toxic substances), Packing Group II, indicating significant transport hazards. Transportation requires UN-approved packaging and proper hazard labeling with appropriate placards and documentation. Only certified carriers with hazardous materials training and permits can transport this substance. The transport vehicle must be equipped with appropriate emergency equipment and spill response materials. Shipping documentation must include proper shipping names, hazard classes, and emergency contact information. Air transport may have additional restrictions due to the substance's toxicity classification.

Is chloromethylbenzene subject to special regulations?

Chloromethylbenzene is subject to extensive regulations due to its carcinogenic classification (Category 1B). Under EU REACH regulation, it requires registration and may have authorization requirements for certain uses. The CLP regulation mandates specific hazard labeling and safety data sheet requirements. Many countries restrict or prohibit its use in consumer products and require occupational exposure limits and health surveillance programs. Import/export may require special permits, and workplace use typically requires notification to regulatory authorities. Regular compliance monitoring and reporting may be mandatory.

Where to buy chloromethylbenzene in Europe?

Chloromethylbenzene is available through specialized chemical distributors like OYSI, which supplies high-quality chemical products across Europe. Due to its hazardous classification, purchase requires proper business credentials, intended use documentation, and compliance with regulatory requirements. OYSI can provide technical support, safety documentation, and regulatory guidance for European customers. Procurement typically involves qualification processes to ensure end-users have appropriate handling capabilities and legitimate industrial applications. Contact OYSI directly for availability, specifications, and regulatory compliance assistance for your specific requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.