Chloromethylbenzene
C7H7Cl
chloromethylbenzene
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Identification
- CAS Number
- 100-44-7
- EC Number
- 202-853-6
- UN Number
- 1738
- Index Number
- 602-037-00-3
- PubChem CID
- 7503
Physical-chemical properties
- Molecular Formula
- C7H7Cl
- Molar Mass
- 126.58 g/mol
- IUPAC Name
- chloromethylbenzene
Chemical Identifiers
- InChI
- InChI=1S/C7H7Cl/c8-6-7-4-2-1-3-5-7/h1-5H,6H2
- InChI Key
- KCXMKQUNVWSEMD-UHFFFAOYSA-N
Overview
Chloromethylbenzene (CAS 100-44-7) is an aromatic halogenated compound with high reactivity and significant industrial importance as a chemical intermediate. This organic compound, also known by its IUPAC name chloromethylbenzene, belongs to the family of benzyl halides and serves as a crucial building block in organic synthesis. With the molecular formula C7H7Cl and a molecular weight of 126.58 g/mol, chloromethylbenzene features a benzene ring substituted with a chloromethyl group, which imparts distinctive reactivity characteristics that make it valuable for various chemical transformations. The compound exhibits significant hazard properties, classified under multiple danger categories including carcinogenicity (Carc. 1B), acute toxicity, and organ toxicity. Its classification under ADR Class 6.1 reflects its toxic nature, requiring careful handling protocols and specialized storage conditions. The presence of GHS pictograms GHS08, GHS06, and GHS05 indicates serious health hazards, toxicity, and corrosive properties that demand professional expertise in handling and application. Industrially, chloromethylbenzene finds primary applications in pharmaceutical intermediate synthesis, where its reactive chloromethyl group enables nucleophilic substitution reactions. It serves as a precursor in the production of various benzyl derivatives and plays a crucial role in polymer chemistry applications. The compound shares chemical relationship with other reactive intermediates such as 1-chloro-4-isocyanatobenzene, both being important building blocks in specialty chemical manufacturing. Due to its hazardous nature, chloromethylbenzene requires specialized handling expertise and regulatory compliance. OYSI provides this technical-grade chemical intermediate to qualified industrial customers with appropriate safety protocols and documentation support.
Safety & Classification
Carc. 1B; Acute Tox. 3 *; Acute Tox. 4 *; STOT SE 3; STOT RE 2 *; Skin Irrit. 2; Eye Dam. 1
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1738 |
| ADR Class | 6.1 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | Benzylchlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is chloromethylbenzene?
Chloromethylbenzene is an aromatic organic compound with the molecular formula C7H7Cl and CAS number 100-44-7. This chemical substance has a molecular weight of 126.58 g/mol and belongs to the family of chlorinated benzyl compounds. It is classified as a highly hazardous substance due to its carcinogenic properties (Category 1B) and various toxicological effects including acute toxicity, skin and eye irritation, and organ toxicity.
What are the physicochemical properties of chloromethylbenzene?
Chloromethylbenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic pungent odor. As an aromatic halogenated compound, it exhibits limited solubility in water but shows good miscibility with organic solvents such as alcohols, ethers, and hydrocarbons. The substance has moderate volatility and can release vapors at ambient temperatures, requiring careful handling in ventilated areas.
What is chloromethylbenzene used for?
Chloromethylbenzene serves primarily as an important chemical intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of various benzyl derivatives, pharmaceuticals, dyes, and specialty chemicals. The compound also finds applications in polymer chemistry as a reactive monomer and in the synthesis of quaternary ammonium compounds. Its reactive chloromethyl group makes it valuable for introducing benzyl functionalities into complex molecules.
How to handle chloromethylbenzene safely?
Chloromethylbenzene requires strict safety measures due to its carcinogenic and toxic properties. Mandatory personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection when ventilation is inadequate. Work must be conducted in well-ventilated areas or under fume hoods. Avoid skin and eye contact completely, prevent inhalation of vapors, and eliminate ignition sources. Emergency shower and eyewash stations should be readily accessible in work areas.
How to store chloromethylbenzene properly?
Chloromethylbenzene must be stored in tightly sealed containers in cool, dry, well-ventilated areas away from heat sources and direct sunlight. Storage areas should be equipped with appropriate containment systems and maintained below 25°C when possible. Keep away from strong oxidizing agents, bases, and metals. Containers should be made of compatible materials such as glass or appropriate plastics. Access must be restricted to trained personnel only.
What to do in case of contact with chloromethylbenzene?
Immediate action is critical following chloromethylbenzene exposure. For skin contact, remove contaminated clothing immediately and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for minimum 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical care. Always consult emergency services for significant exposures.
How to dispose of chloromethylbenzene appropriately?
Chloromethylbenzene disposal must comply with local and national hazardous waste regulations due to its carcinogenic classification. The substance cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small quantities should be collected in appropriate containers and labeled clearly. Incineration at approved high-temperature facilities is typically the preferred disposal method.
How to transport chloromethylbenzene?
Chloromethylbenzene is classified under ADR Class 6.1 (toxic substances) Packing Group II, requiring specialized transport procedures. Packages must bear appropriate hazard labels and UN identification numbers. Transport vehicles need proper placarding and emergency equipment. Drivers must hold valid ADR certificates and carry transport documents. Packages should be secured against movement and protected from temperature extremes during transit. Compliance with international dangerous goods regulations is mandatory.
Is chloromethylbenzene subject to specific regulations?
Chloromethylbenzene is subject to extensive regulatory oversight under REACH, CLP, and national chemical safety legislation. As a Category 1B carcinogen, it faces strict classification and labeling requirements with 'Danger' signal word and specific hazard pictograms (GHS08, GHS06, GHS05). Users must implement appropriate risk management measures and may require authorization for certain uses. Regular safety data sheet updates and worker health surveillance programs are typically mandatory.
Where to buy chloromethylbenzene in Europe?
Chloromethylbenzene is available through specialized chemical distributors across Europe, including OYSI, a professional European distributor of technical chemicals. Due to its hazardous classification, purchases typically require verification of legitimate industrial use and appropriate safety capabilities. Suppliers must provide comprehensive safety data sheets and ensure compliance with transport regulations. Contact OYSI's technical team for availability, specifications, and regulatory support for your specific application requirements.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.