2-chloroacetaldehyde

C2H3ClO

CAS107-20-0
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
107-20-0
EC Number
203-472-8
UN Number
2232
Index Number
605-025-00-6
PubChem CID
33

Physical-chemical properties

Molecular Formula
C2H3ClO
Molar Mass
78.50 g/mol
IUPAC Name
2-chloroacetaldehyde

Chemical Identifiers

InChI
InChI=1S/C2H3ClO/c3-1-2-4/h2H,1H2
InChI Key
QSKPIOLLBIHNAC-UHFFFAOYSA-N

Overview

2-chloroacetaldehyde (CAS 107-20-0) is a halogenated aldehyde compound with high reactivity and significant toxicity concerns for industrial applications. 2-chloroacetaldehyde represents a critical intermediate in organic synthesis, featuring both aldehyde and halogen functionalities that make it valuable for various chemical transformations. This colorless to pale yellow liquid exhibits the molecular formula C2H3ClO with a molecular weight of 78.5 g/mol, positioning it among the lighter halogenated aldehydes used in industrial chemistry. The compound's dual reactive sites enable diverse synthetic pathways, making it particularly useful in pharmaceutical intermediates and specialty chemical production. The substance carries significant safety considerations, classified under multiple hazard categories including carcinogenicity (Category 2), acute toxicity, and skin corrosion. The GHS pictograms GHS08, GHS06, GHS05, and GHS09 reflect its serious health hazards, corrosive properties, and aquatic toxicity. Its ADR classification as Class 6.1 emphasizes the need for specialized handling and transport protocols. The compound's reactivity profile differs from related halogenated compounds such as 2,2-dibromo-2-cyanoacetamide, which contains additional functional groups that modify its chemical behavior. Primary industrial applications include pharmaceutical synthesis where 2-chloroacetaldehyde serves as a building block for active pharmaceutical ingredients, agrochemical production for pesticide intermediates, and specialty polymer chemistry. Its electrophilic nature makes it valuable in nucleophilic substitution reactions and cyclization processes. OYSI provides 2-chloroacetaldehyde to European industrial customers with comprehensive technical support and regulatory documentation to ensure safe handling and compliance with REACH requirements.

Safety & Classification

Danger
Classification:

Carc. 2; Acute Tox. 2 *; Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Acute 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H330

Fatal if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H314

Causes severe skin burns and eye damage.

H400

Very toxic to aquatic life.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Fatal

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2232
ADR Class6.1
Packing GroupI
Tunnel CodeC/D
Proper Shipping Name2-Chlorethanal
Marine PollutantNo

Frequently Asked Questions

What is 2-chloroacetaldehyde?

2-chloroacetaldehyde is a chlorinated organic compound with the molecular formula C2H3ClO and CAS number 107-20-0. This chemical substance has a molecular weight of 78.5 g/mol and belongs to the aldehyde family. It is classified as a highly hazardous substance with multiple danger classifications including carcinogenic properties (Carc. 2), acute toxicity, skin corrosion, and aquatic toxicity. The compound requires careful handling due to its significant health and environmental risks.

What are the physicochemical properties of 2-chloroacetaldehyde?

2-chloroacetaldehyde is typically a colorless to pale yellow liquid at room temperature with a pungent, acrid odor characteristic of aldehydes. The compound is highly reactive due to both its aldehyde functional group and the presence of chlorine. It is miscible with water and most organic solvents, making it highly mobile in various environments. The substance is volatile and can easily evaporate, contributing to its inhalation hazard potential.

What is 2-chloroacetaldehyde used for?

2-chloroacetaldehyde is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a building block for producing various chemicals, including pharmaceuticals, agrochemicals, and specialty organic compounds. The compound is also utilized in research laboratories for synthetic chemistry applications. Due to its high toxicity and carcinogenic properties, its use is restricted to professional industrial applications with appropriate safety measures and regulatory compliance.

How to handle 2-chloroacetaldehyde safely?

2-chloroacetaldehyde requires maximum protection during handling due to its extreme hazards. Essential PPE includes full-face respirators with appropriate cartridges, chemical-resistant gloves (nitrile or neoprene), complete body protection suits, and safety goggles. Work must be conducted in well-ventilated areas or under fume hoods. Avoid skin contact, inhalation, and ingestion completely. Emergency eyewash stations and safety showers must be readily accessible. Only trained personnel should handle this substance.

How to store 2-chloroacetaldehyde correctly?

2-chloroacetaldehyde must be stored in tightly sealed, chemically compatible containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Storage areas should be equipped with appropriate containment systems and maintained at controlled temperatures. Keep away from incompatible materials such as strong bases, oxidizing agents, and metals. Access should be restricted to authorized personnel only, with proper inventory tracking and emergency response procedures in place.

What to do in case of contact with 2-chloroacetaldehyde?

Immediate action is critical for any exposure to 2-chloroacetaldehyde. For skin contact, remove contaminated clothing and flush affected area with copious amounts of water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. For eye contact, rinse continuously with water for at least 15 minutes. In all cases, seek immediate medical attention and inform healthcare providers of the specific chemical involved. Never induce vomiting if ingested.

How to dispose of 2-chloroacetaldehyde properly?

2-chloroacetaldehyde disposal must comply with local, national, and EU hazardous waste regulations due to its classification as dangerous waste. The substance requires treatment at authorized hazardous waste facilities equipped to handle toxic and potentially carcinogenic materials. Incineration at high temperatures in specialized facilities is typically the preferred disposal method. Never dispose of through regular waste streams, sewers, or soil. Contact licensed hazardous waste contractors for proper collection and disposal procedures.

How to transport 2-chloroacetaldehyde?

2-chloroacetaldehyde is classified under ADR Class 6.1 (Toxic substances) Packing Group I, indicating maximum transport restrictions due to its high toxicity. Transportation requires UN-approved packaging, proper labeling with GHS pictogrammes (GHS05, GHS06, GHS08, GHS09), and transport documents specifying the hazard class. Only certified carriers trained in dangerous goods transport can handle shipments. Emergency response information and appropriate safety equipment must accompany all shipments according to ADR regulations.

Is 2-chloroacetaldehyde subject to specific regulations?

2-chloroacetaldehyde is subject to extensive European regulations under REACH and CLP classifications. Its Carc. 2 classification means it requires authorization for many uses and is subject to strict occupational exposure limits. The substance falls under various industrial emissions directives and workplace safety regulations. Companies using this chemical must maintain detailed safety data sheets, conduct risk assessments, and implement appropriate risk management measures. Regular monitoring and reporting may be required depending on usage quantities.

Where to buy 2-chloroacetaldehyde in Europe?

2-chloroacetaldehyde is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. As a regulated substance with significant hazard classifications, purchase requires proper documentation, safety certifications, and compliance with local regulations. OYSI provides technical support and ensures proper handling procedures for delivery. Contact OYSI directly to discuss availability, regulatory requirements, and safe supply chain management for your specific application needs.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.