1,2-dimethoxyethane

C4H10O2

CAS110-71-4
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
Danger

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Identification

CAS Number
110-71-4
EC Number
203-794-9
UN Number
2252
Index Number
603-031-00-3
PubChem CID
8071

Physical-chemical properties

Molecular Formula
C4H10O2
Molar Mass
90.12 g/mol
IUPAC Name
1,2-dimethoxyethane

Chemical Identifiers

InChI
InChI=1S/C4H10O2/c1-5-3-4-6-2/h3-4H2,1-2H3
InChI Key
XTHFKEDIFFGKHM-UHFFFAOYSA-N

Overview

1,2-Dimethoxyethane (CAS 110-71-4) is a glycol ether solvent with excellent solvating properties and low viscosity characteristics. This versatile organic compound, also known by its IUPAC designation 1,2-dimethoxyethane, serves as a crucial industrial solvent across multiple sectors. With the molecular formula C4H10O2 and molecular weight of 90.12 g/mol, this colorless liquid exhibits exceptional dissolving capabilities for both polar and non-polar substances, making it particularly valuable in specialized chemical processes. The substance presents significant safety considerations that require careful handling protocols. Classified under multiple hazard categories including Flammable Liquid Category 2, Reproductive Toxicity Category 1B, and Acute Toxicity Category 4, it demands strict adherence to safety measures. The GHS pictograms GHS02, GHS07, and GHS08 indicate fire hazards, health warnings, and serious health risks respectively, while its ADR Class 3 classification governs transportation requirements. Primary industrial applications include its use as a reaction medium in organometallic chemistry, particularly in Grignard reactions and lithium-based syntheses where its coordinating properties prove essential. The pharmaceutical industry utilizes 1,2-dimethoxyethane in drug synthesis processes, while the electronics sector employs it in battery electrolyte formulations. Unlike aromatic solvents such as ethylbenzene or styrene, this glycol ether offers unique coordination chemistry benefits that make it irreplaceable in certain synthetic pathways. Due to its reproductive toxicity classification, proper ventilation, personal protective equipment, and specialized storage conditions are mandatory. Workers must receive appropriate training on handling procedures and emergency response protocols. OYSI maintains reliable supply chains for 1,2-dimethoxyethane to support European industrial customers requiring this specialized solvent for their manufacturing processes.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; Repr. 1B; Acute Tox. 4 *

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H332

Harmful if inhaled.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2252
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name1,2-Dimethoxyethan
Marine PollutantNo

Frequently Asked Questions

What is 1,2-dimethoxyethane?

1,2-dimethoxyethane is an organic chemical compound with the molecular formula C4H10O2 and CAS number 110-71-4. It belongs to the ether family and has a molecular weight of 90.12 g/mol. This substance is classified as a flammable liquid with reproductive toxicity and acute toxicity properties. It is commonly used as a solvent and chelating agent in various industrial applications due to its ability to coordinate with metal ions through its two oxygen atoms.

What are the physicochemical properties of 1,2-dimethoxyethane?

1,2-dimethoxyethane is a colorless liquid at room temperature with a characteristic ether-like odor. It has excellent solubility in water and most organic solvents due to its ether groups. The compound has a relatively low boiling point and high volatility. Its chemical structure, containing two methoxy groups attached to an ethane backbone, gives it unique chelating properties that make it valuable as a coordinating solvent for organometallic reactions and metal complexes.

What is 1,2-dimethoxyethane used for?

1,2-dimethoxyethane is primarily used as a coordinating solvent in organometallic chemistry and lithium battery electrolytes. It serves as an excellent medium for Grignard reactions and other organometallic syntheses due to its ability to stabilize metal ions. The compound is also employed in polymer chemistry, pharmaceutical synthesis, and as a reaction medium for various chemical processes. Its chelating properties make it particularly valuable in applications requiring metal ion coordination and stabilization.

How to handle 1,2-dimethoxyethane safely?

1,2-dimethoxyethane requires careful handling due to its flammable, reproductive toxic, and acutely toxic properties. Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to prevent vapor inhalation. Keep away from ignition sources, heat, and sparks. Avoid skin contact and inhalation. Pregnant women should avoid exposure due to reproductive toxicity concerns. Ensure proper grounding of equipment to prevent static discharge.

How to store 1,2-dimethoxyethane correctly?

1,2-dimethoxyethane should be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Keep containers tightly closed and store in original packaging. Maintain storage temperature below 25°C and protect from direct sunlight. Store separately from oxidizing agents, acids, and incompatible materials. Ensure adequate fire prevention measures and emergency equipment are available. Check containers regularly for leaks or damage, and maintain proper inventory records for regulatory compliance.

What to do in case of contact with 1,2-dimethoxyethane?

In case of skin contact with 1,2-dimethoxyethane, immediately remove contaminated clothing and wash the affected area with plenty of soap and water for at least 15 minutes. If inhaled, move the person to fresh air immediately and seek medical attention if breathing difficulties occur. In case of eye contact, rinse thoroughly with water for at least 15 minutes and remove contact lenses if present. If ingested, do not induce vomiting and seek immediate medical attention. Always consult a physician in case of exposure.

How to dispose of 1,2-dimethoxyethane properly?

1,2-dimethoxyethane must be disposed of as hazardous waste according to local, national, and international regulations. Never pour down drains, into soil, or release into the environment. Contact licensed waste disposal companies for proper collection and treatment. Small quantities may be suitable for incineration at authorized facilities with appropriate emission controls. Maintain proper documentation of waste disposal activities. Consider recovery or recycling options where technically and economically feasible to minimize environmental impact.

How to transport 1,2-dimethoxyethane?

1,2-dimethoxyethane is classified as ADR Class 3 (flammable liquid) Packing Group II for transportation purposes. It must be shipped in appropriate UN-specification packaging with proper labeling including GHS02, GHS07, and GHS08 pictograms. Transport vehicles must comply with ADR regulations for flammable liquids. Proper shipping documentation, including safety data sheets, must accompany shipments. Only authorized carriers experienced in handling hazardous materials should transport this substance. Emergency response information must be readily available during transport.

Is 1,2-dimethoxyethane subject to specific regulations?

1,2-dimethoxyethane is subject to various European regulations including REACH registration requirements and CLP classification as Flam. Liq. 2, Repr. 1B, and Acute Tox. 4. While not currently listed as a SVHC, it requires safety data sheets and appropriate hazard labeling with the "Danger" signal word. Users must comply with occupational exposure limits and workplace safety regulations. Industrial users may need to implement risk management measures and report usage under REACH. Regular monitoring of regulatory updates is recommended.

Where to buy 1,2-dimethoxyethane in Europe?

1,2-dimethoxyethane is available through OYSI, a leading European distributor of technical chemicals serving industrial and professional customers across Europe. OYSI provides reliable supply with proper documentation, safety data sheets, and regulatory compliance support. As an established chemical distributor, OYSI ensures product quality and handles all necessary transportation requirements according to ADR regulations. Contact OYSI directly for specific availability, packaging options, and technical support for your 1,2-dimethoxyethane requirements in European markets.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.