Diethyl oxalate
C6H10O4
diethyl oxalate
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Identification
- CAS Number
- 95-92-1
- EC Number
- 202-464-1
- UN Number
- 2525
- Index Number
- 607-147-00-5
- PubChem CID
- 7268
Physical-chemical properties
- Molecular Formula
- C6H10O4
- Molar Mass
- 146.14 g/mol
- IUPAC Name
- diethyl oxalate
Chemical Identifiers
- InChI
- InChI=1S/C6H10O4/c1-3-9-5(7)6(8)10-4-2/h3-4H2,1-2H3
- InChI Key
- WYACBZDAHNBPPB-UHFFFAOYSA-N
Overview
Diethyl oxalate (CAS 95-92-1) is an organic ester compound with crystalline structure and moderate toxicity properties used in chemical synthesis applications. This dicarboxylic acid diester serves as an important intermediate in organic chemistry and industrial processes. With the molecular formula C6H10O4 and a molecular weight of 146.14 g/mol, diethyl oxalate appears as a white to off-white crystalline solid at room temperature. The compound is formed through the esterification of oxalic acid with ethanol, resulting in a symmetrical structure that makes it valuable for various synthetic pathways. From a safety perspective, diethyl oxalate is classified under GHS as Acute Toxicity Category 4 and Eye Irritation Category 2, requiring careful handling procedures. The compound carries the warning signal word and GHS07 pictogram, indicating its potential health hazards. Its ADR classification as Class 6.1 substances reflects its toxic properties during transportation and storage. Proper personal protective equipment and adequate ventilation are essential when working with this material. In industrial applications, diethyl oxalate functions primarily as a synthetic building block in pharmaceutical intermediates and fine chemical manufacturing. It serves as a key reagent in the preparation of various heterocyclic compounds and can be utilized in polymer chemistry applications. The compound also finds use in specialized organic synthesis reactions where its diester functionality provides unique reactivity patterns, sometimes in conjunction with other industrial chemicals like 1-phenylethanone in multi-step synthetic processes. OYSI maintains reliable supply chains for diethyl oxalate to support European chemical manufacturers and research institutions requiring this specialized intermediate compound.
Safety & Classification
Acute Tox. 4 *; Eye Irrit. 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2525 |
| ADR Class | 6.1 |
| Packing Group | III |
| Tunnel Code | E |
| Proper Shipping Name | Ethyloxalat |
| Marine Pollutant | No |
Frequently Asked Questions
What is diethyl oxalate?
Diethyl oxalate is an organic chemical compound with the molecular formula C6H10O4 and CAS number 95-92-1. It is the diethyl ester of oxalic acid, featuring two ethyl groups attached to the oxalate backbone. With a molecular weight of 146.14 g/mol, this compound appears as a colorless liquid and is classified as a moderately hazardous substance with acute toxicity and eye irritation properties under GHS classification.
What are the physicochemical properties of diethyl oxalate?
Diethyl oxalate is a colorless, oily liquid at room temperature with a characteristic ester odor. It has a molecular weight of 146.14 g/mol and is moderately soluble in water while being fully miscible with organic solvents like ethanol and ether. The compound has a boiling point around 186°C and a density of approximately 1.08 g/cm³, making it slightly denser than water.
What is diethyl oxalate used for?
Diethyl oxalate is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a building block for the production of various organic compounds, including pharmaceuticals, agrochemicals, and specialty chemicals. The compound is also utilized in research laboratories for synthetic chemistry applications and as a reagent in certain analytical procedures. Its ester functionality makes it valuable for further chemical transformations.
How to handle diethyl oxalate safely?
Diethyl oxalate must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. The substance is classified as Acute Tox. 4 and Eye Irrit. 2, requiring careful handling to prevent accidental exposure and potential health effects.
How to store diethyl oxalate correctly?
Diethyl oxalate should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. The storage area must be equipped with appropriate spill containment measures and maintained at stable temperatures to prevent degradation. Keep containers properly labeled and away from incompatible materials. Regular inspection of storage containers is recommended to ensure integrity and prevent leakage.
What to do in case of contact with diethyl oxalate?
In case of skin contact with diethyl oxalate, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention.
How to dispose of diethyl oxalate appropriately?
Diethyl oxalate must be disposed of in accordance with local, national, and international waste regulations as hazardous chemical waste. The substance cannot be disposed of in regular waste streams or poured down drains. Contact licensed waste disposal companies specialized in chemical waste treatment. Small quantities may be neutralized or incinerated under controlled conditions by qualified professionals following appropriate environmental protection protocols.
How to transport diethyl oxalate?
Diethyl oxalate is classified under ADR as Class 6.1 (Toxic substances), Packing Group III for transportation purposes. It must be packaged in UN-approved containers with proper labeling including the GHS07 pictogram and 'Warning' signal word. Transportation documentation must include the proper shipping name, UN number, and hazard class. Vehicles must comply with ADR requirements for toxic substance transport.
Is diethyl oxalate subject to specific regulations?
Diethyl oxalate is subject to REACH regulation in Europe and must comply with CLP classification requirements. It is classified as Acute Tox. 4 and Eye Irrit. 2, requiring appropriate safety data sheets and hazard communication. The substance is not currently listed as a Substance of Very High Concern (SVHC). Users must follow occupational safety regulations and ensure proper risk assessment and management measures are implemented.
Where to buy diethyl oxalate in Europe?
Diethyl oxalate is available through OYSI, a European distributor specializing in technical chemical products. OYSI provides high-quality diethyl oxalate with complete documentation including safety data sheets, certificates of analysis, and regulatory compliance information. As an established European chemical distributor, OYSI ensures reliable supply chains and technical support for industrial customers requiring this specialty chemical compound.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.