4-ethoxyaniline

4-ethoxyaniline is an organic chemical compound with the molecular formula C8H11NO and CAS number 156-43-4. It belongs to the aniline family, featuring an amino group attached to a benzene ring with an ethoxy substituent in the para position. With a molecular weight of 137.18 g/mol, this aromatic amine is classified as a mutagenic substance and requires careful handling due to its toxicological properties.

4-ethoxyaniline is typically a crystalline solid at room temperature with a characteristic aromatic amine odor. As an aromatic ether-amine compound, it exhibits moderate polarity due to both the amino and ethoxy functional groups. The substance shows limited water solubility but dissolves well in organic solvents like alcohols and aromatic hydrocarbons. Its molecular structure contributes to its stability under normal conditions.

4-ethoxyaniline serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of dyes, pigments, and various organic compounds through its reactive amino group. The compound finds applications in research laboratories for chemical synthesis and as a building block for more complex molecules. Its aromatic structure makes it valuable in developing specialty chemicals and advanced materials.

4-ethoxyaniline requires careful handling due to its mutagenic properties and acute toxicity. Essential protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection when working with powders or in poorly ventilated areas. Work should be conducted in well-ventilated spaces or under fume hoods. Avoid skin contact, inhalation, and ingestion. Implement strict hygiene measures and ensure personnel are trained in chemical safety protocols.

4-ethoxyaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers upright and properly labeled with hazard information. Store separately from strong oxidizing agents, acids, and incompatible materials. Maintain storage temperatures within recommended ranges and ensure adequate secondary containment. Regular inspection of containers for damage or leaks is essential for safe storage.

Immediate action is required following contact with 4-ethoxyaniline. For skin contact, remove contaminated clothing and wash affected areas thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention, providing safety data sheet information to healthcare providers.

4-ethoxyaniline disposal must comply with local and national hazardous waste regulations due to its toxicological properties. The substance cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment. Contact licensed waste disposal companies for proper collection and treatment. Incineration at high temperatures in authorized facilities is typically the preferred disposal method. Maintain proper documentation of all disposal activities as required by regulations.

4-ethoxyaniline is classified under ADR as Class 6.1 (toxic substances), Packing Group III, requiring compliance with dangerous goods transportation regulations. Packages must bear appropriate hazard labels and markings including the proper shipping name and UN number. Use approved packaging materials and ensure proper documentation including transport documents and emergency response information. Only authorized carriers trained in dangerous goods transport should handle shipments.

4-ethoxyaniline falls under European REACH regulation requiring registration for manufacture or import above certain tonnages. The substance is classified under CLP regulation with specific hazard classifications including mutagenicity category 2 and acute toxicity. While not currently listed as an SVHC, its mutagenic properties subject it to strict handling and exposure control requirements. National occupational exposure limits may apply in various European countries.

4-ethoxyaniline is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. As a professional chemical supplier, OYSI ensures proper handling, documentation, and regulatory compliance for hazardous substances. Contact OYSI directly for availability, technical specifications, safety data sheets, and delivery options. Professional customers can access this regulated substance through established chemical distribution networks with appropriate safety protocols.