4-ethoxyaniline

4-ethoxyaniline is an aromatic amine compound with the molecular formula C8H11NO and CAS number 156-43-4. This organic chemical belongs to the aniline derivative family, characterized by an ethoxy group (-OC2H5) attached to the benzene ring at the para position relative to the amino group. With a molecular weight of 137.18 g/mol, it appears as a crystalline solid and is classified as a mutagenic substance requiring careful handling procedures.

4-ethoxyaniline is a solid crystalline compound at room temperature, typically appearing as white to light brown crystals or powder. It has a molecular weight of 137.18 g/mol and contains an ethoxy substituent that influences its solubility properties. The compound is moderately soluble in organic solvents like ethanol and acetone, while having limited water solubility. Its aromatic amine structure gives it basic properties and makes it reactive toward electrophilic substitution reactions.

4-ethoxyaniline is primarily used as an intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. It serves as a building block in organic synthesis for producing various aromatic compounds, particularly in the manufacture of azo dyes and other colorants. The compound is also utilized in the production of specialty chemicals and as a precursor for pharmaceutical active ingredients, making it valuable in both the chemical and pharmaceutical industries.

4-ethoxyaniline requires careful handling due to its mutagenic properties and acute toxicity. Personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing must be worn. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact, and ensure no eating, drinking, or smoking in work areas. Emergency eyewash stations and safety showers should be readily accessible during handling operations.

4-ethoxyaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers away from incompatible materials such as strong oxidizing agents and acids. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures. Ensure proper labeling with hazard warnings and restrict access to authorized personnel only. Regular inspection of containers for damage or leakage is recommended.

In case of skin contact with 4-ethoxyaniline, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15-20 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician and provide the safety data sheet.

4-ethoxyaniline disposal must comply with local and national hazardous waste regulations due to its mutagenic classification. The substance should be treated as hazardous waste and disposed of through licensed waste management facilities capable of handling toxic organic compounds. Incineration at high temperatures in approved facilities is typically the preferred method. Never dispose of this chemical through regular waste streams or pour it down drains. Consult local environmental authorities for specific disposal requirements.

4-ethoxyaniline is classified as ADR Class 6.1 (toxic substances), Packing Group III for transportation purposes. It must be packaged in UN-approved containers with appropriate hazard labels and documentation. Transport vehicles require proper placarding and drivers need hazardous materials certification. The substance should be secured to prevent movement during transit and separated from incompatible materials. Emergency response information must accompany shipments, and transport should follow designated routes where applicable.

4-ethoxyaniline is subject to various chemical regulations including REACH registration requirements in the European Union and CLP classification obligations. Its mutagenic properties (Muta. 2) place it under strict regulatory oversight for occupational health and safety. Users must comply with worker protection regulations and may need to implement specific risk management measures. The substance requires proper classification, labeling, and safety data sheet provision according to GHS standards and local chemical legislation.

4-ethoxyaniline is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across the continent. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support. As a professional chemical distributor, OYSI ensures reliable supply chains and technical expertise for industrial applications. Contact OYSI directly for availability, specifications, and pricing information tailored to your specific requirements and application needs.