Bromomethylbenzene
C7H7Br
bromomethylbenzene
Consulting for Bromomethylbenzene
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Identification
- CAS Number
- 100-39-0
- EC Number
- 202-847-3
- UN Number
- 1737
- Index Number
- 602-057-00-2
- PubChem CID
- 7498
Physical-chemical properties
- Molecular Formula
- C7H7Br
- Molar Mass
- 171.03 g/mol
- IUPAC Name
- bromomethylbenzene
Chemical Identifiers
- InChI
- InChI=1S/C7H7Br/c8-6-7-4-2-1-3-5-7/h1-5H,6H2
- InChI Key
- AGEZXYOZHKGVCM-UHFFFAOYSA-N
Overview
Bromomethylbenzene (CAS 100-39-0) is an aromatic halide compound characterized by high reactivity and significant industrial utility in organic synthesis applications. This benzyl bromide derivative represents a crucial building block in organic chemistry, featuring a bromine atom attached to a methyl group that is directly bonded to a benzene ring. The compound exhibits exceptional reactivity due to the activated benzyl position, making it highly valuable for nucleophilic substitution reactions and various synthetic transformations. With its molecular formula C7H7Br and molecular weight of 171.03 g/mol, bromomethylbenzene serves as an important intermediate in pharmaceutical manufacturing, specialty chemical production, and research applications. From a safety perspective, bromomethylbenzene requires careful handling protocols due to its classification under ADR Class 6.1 and GHS07 pictogram designation. The compound presents moderate hazard concerns including skin and eye irritation properties, along with specific target organ toxicity potential, warranting appropriate personal protective equipment and ventilation systems during industrial use. Its Warning signal word indicates the necessity for standard chemical handling precautions in professional environments. Industrial applications primarily focus on pharmaceutical intermediate synthesis, where bromomethylbenzene facilitates the production of various drug compounds and active pharmaceutical ingredients. The chemical also finds extensive use in specialty polymer production and as a reagent in fine chemical manufacturing processes. Unlike more corrosive compounds such as tetrachlorosilane, bromomethylbenzene offers controlled reactivity suitable for precision synthesis work while maintaining industrial scalability. OYSI maintains reliable supply chains for bromomethylbenzene to support European industrial customers requiring consistent quality and technical specifications for their manufacturing processes.
Safety & Classification
STOT SE 3; Skin Irrit. 2; Eye Irrit. 2
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1737 |
| ADR Class | 6.1 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | Benzylbromid |
| Marine Pollutant | No |
Frequently Asked Questions
What is bromomethylbenzene?
Bromomethylbenzene is an aromatic organobromine compound with the molecular formula C7H7Br and CAS number 100-39-0. It consists of a benzene ring substituted with a bromomethyl group (-CH2Br). With a molecular weight of 171.03 g/mol, this substance is classified as a moderate health hazard, causing skin and eye irritation and specific target organ toxicity. It carries the GHS07 pictogram and Warning signal word under CLP regulation.
What are the physicochemical properties of bromomethylbenzene?
Bromomethylbenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. As an aromatic halide, it has limited solubility in water but dissolves readily in organic solvents such as alcohols, ethers, and hydrocarbons. The compound exhibits moderate volatility and density higher than water due to the presence of the bromine atom, which contributes to its molecular weight of 171.03 g/mol.
What is bromomethylbenzene used for?
Bromomethylbenzene serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of various benzyl derivatives, pharmaceutical compounds, and specialty chemicals. The compound acts as an alkylating agent in chemical reactions and finds applications in the synthesis of quaternary ammonium compounds, pharmaceutical intermediates, and other fine chemicals in research and industrial settings.
How to handle bromomethylbenzene safely?
Bromomethylbenzene requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. Given its STOT SE 3 classification and irritant properties, minimize direct contact and ensure proper ventilation. Always follow established safety protocols and have emergency procedures readily available.
How to store bromomethylbenzene correctly?
Bromomethylbenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and incompatible materials. Keep containers in secondary containment to prevent spills and ensure proper labeling with hazard information. Store separately from strong bases, oxidizing agents, and reactive metals. Maintain storage temperatures as recommended by the supplier and regularly inspect containers for signs of deterioration or leakage.
What to do in case of contact with bromomethylbenzene?
Bromomethylbenzene contact requires immediate action: for skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Remove contaminated clothing and wash before reuse. Seek medical attention if irritation persists or if large amounts were involved in the exposure.
How to dispose of bromomethylbenzene properly?
Bromomethylbenzene disposal must comply with local, national, and international waste regulations as it is classified as hazardous waste. Do not dispose of in regular trash or pour down drains. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small laboratory quantities may be suitable for incineration at authorized facilities. Always consult current waste disposal regulations and maintain proper documentation for waste tracking and compliance purposes.
How to transport bromomethylbenzene?
Bromomethylbenzene is classified under ADR as Class 6.1 (toxic substances), Packing Group II, requiring specific transport protocols for dangerous goods. Packages must bear appropriate hazard labels and proper shipping names. Drivers need ADR certification for toxic substance transport. Use UN-approved packaging and ensure proper documentation including transport documents and emergency response information. Comply with quantity limitations and routing restrictions as specified in ADR regulations.
Is bromomethylbenzene subject to specific regulations?
Bromomethylbenzene is subject to various chemical regulations including REACH registration requirements for import/manufacture in the EU and CLP classification obligations. It is not currently listed as a Substance of Very High Concern (SVHC) under REACH. Users must comply with workplace safety regulations, transport requirements under ADR, and proper hazard communication through safety data sheets. Always verify current regulatory status as requirements may change over time.
Where to buy bromomethylbenzene in Europe?
Bromomethylbenzene is available through OYSI, a European distributor specializing in technical chemical products. As an established chemical supplier, OYSI can provide this compound with proper documentation, safety data sheets, and regulatory compliance support for European customers. Contact OYSI directly for availability, technical specifications, packaging options, and delivery throughout Europe. Ensure you have appropriate handling capabilities and regulatory compliance before ordering this hazardous substance.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.