Bromomethylbenzene

C7H7Br

bromomethylbenzene

CAS100-39-0
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
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Identification

CAS Number
100-39-0
EC Number
202-847-3
UN Number
1737
Index Number
602-057-00-2
PubChem CID
7498

Physical-chemical properties

Molecular Formula
C7H7Br
Molar Mass
171.03 g/mol
IUPAC Name
bromomethylbenzene

Chemical Identifiers

InChI
InChI=1S/C7H7Br/c8-6-7-4-2-1-3-5-7/h1-5H,6H2
InChI Key
AGEZXYOZHKGVCM-UHFFFAOYSA-N

Overview

Bromomethylbenzene (CAS 100-39-0) is an aromatic halide compound with electrophilic properties used primarily as a chemical intermediate in organic synthesis. This benzyl bromide derivative represents a crucial building block in pharmaceutical and fine chemical manufacturing. The compound features a bromine atom attached to the methyl group of toluene, creating a highly reactive benzyl halide that serves as an important alkylating agent in various synthetic pathways. Its molecular structure (C7H7Br) combines the stability of an aromatic ring with the reactivity of a primary alkyl bromide, making it particularly valuable for nucleophilic substitution reactions. Bromomethylbenzene presents moderate health hazards, classified under GHS07 pictogram with warnings for skin and eye irritation, as well as specific target organ toxicity. The compound requires careful handling due to its ADR Class 6.1 classification, indicating toxic properties that necessitate appropriate safety protocols during storage, transport, and use. Proper ventilation and personal protective equipment are essential when working with this material. Industrial applications include pharmaceutical intermediate synthesis, where bromomethylbenzene serves as a key starting material for various drug compounds. It also functions as a reagent in the production of quaternary ammonium compounds and as an alkylating agent in polymer chemistry. Unlike more aggressive halogenating agents such as tetrachlorosilane, bromomethylbenzene offers selective reactivity that makes it suitable for delicate synthetic transformations. OYSI maintains reliable supply chains for bromomethylbenzene across European markets, supporting pharmaceutical manufacturers, chemical synthesizers, and research institutions with consistent product availability and technical support services.

Safety & Classification

Warning
Classification:

STOT SE 3; Skin Irrit. 2; Eye Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H335

May cause respiratory irritation.

H315

Causes skin irritation.

H319

Causes serious eye irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Irritant

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1737
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameBenzylbromid
Marine PollutantNo

Frequently Asked Questions

What is bromomethylbenzene?

Bromomethylbenzene is an aromatic organobromine compound with the molecular formula C7H7Br and CAS number 100-39-0. This chemical features a benzene ring with a bromomethyl substituent, giving it a molecular weight of 171.03 g/mol. It is classified as a hazardous substance with moderate toxicity, requiring careful handling due to its potential to cause skin and eye irritation as well as specific target organ toxicity.

What are the physicochemical properties of bromomethylbenzene?

Bromomethylbenzene is typically a colorless to pale yellow liquid at room temperature with a characteristic aromatic odor. The compound has a molecular weight of 171.03 g/mol and contains a reactive bromomethyl group attached to a benzene ring. It exhibits limited solubility in water but dissolves readily in organic solvents such as alcohols, ethers, and aromatic hydrocarbons, making it suitable for various organic synthesis applications.

What is bromomethylbenzene used for?

Bromomethylbenzene serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of various chemical compounds through nucleophilic substitution reactions, where the bromine atom can be replaced with other functional groups. The compound finds applications in the synthesis of specialty chemicals, pharmaceutical intermediates, and research chemicals in laboratory settings and industrial processes.

How to handle bromomethylbenzene safely?

Safe handling of bromomethylbenzene requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid direct skin and eye contact, as the substance can cause irritation. Use proper laboratory techniques, ensure adequate ventilation, and have emergency procedures in place for potential exposure incidents.

How to store bromomethylbenzene correctly?

Bromomethylbenzene should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep the substance away from incompatible materials such as strong oxidizing agents and bases that could react with the bromomethyl group. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures to prevent degradation or unwanted reactions.

What to do in case of contact with bromomethylbenzene?

In case of skin contact with bromomethylbenzene, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for 15-20 minutes and seek medical attention. If inhaled, move the person to fresh air and seek medical advice if symptoms persist. Remove contaminated clothing and wash before reuse.

How to dispose of bromomethylbenzene properly?

Proper disposal of bromomethylbenzene must comply with local and international hazardous waste regulations. The substance should not be discharged into sewers or the environment. Contact licensed hazardous waste disposal companies for appropriate treatment and disposal methods. Small laboratory quantities may be collected for incineration at specialized facilities equipped to handle organobromine compounds while preventing the formation of harmful by-products.

How to transport bromomethylbenzene?

Bromomethylbenzene is classified under ADR Class 6.1 (toxic substances) Packing Group II, requiring specific transport procedures for hazardous materials. The substance must be packaged in approved containers with proper labeling including the GHS07 pictogram and 'Warning' signal word. Transportation should follow ADR regulations for toxic substances, including proper documentation, vehicle placarding, and driver certification for hazardous materials transport.

Is bromomethylbenzene subject to specific regulations?

Bromomethylbenzene is subject to various chemical regulations including REACH registration requirements in Europe and CLP classification as STOT SE 3, Skin Irritant 2, and Eye Irritant 2. While not currently listed as an SVHC (Substance of Very High Concern), it requires proper safety data sheets, hazard communication, and compliance with occupational exposure limits. Users must follow proper risk assessment and management measures under applicable chemical safety regulations.

Where to buy bromomethylbenzene in Europe?

Bromomethylbenzene is available through OYSI, a European chemical distributor specializing in technical chemical products. OYSI provides reliable supply chains across Europe with proper documentation and regulatory compliance. As an established chemical distributor, OYSI ensures product quality, proper packaging, and adherence to transportation regulations for hazardous materials, making them a trusted source for industrial and research applications requiring this specialized chemical intermediate.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.