1,2-diphenylguanidine

C13H13N3

CAS102-06-7
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
102-06-7
EC Number
203-002-1
UN Number
2811
Index Number
612-149-00-4
PubChem CID
7594

Physical-chemical properties

Molecular Formula
C13H13N3
Molar Mass
211.26 g/mol
IUPAC Name
1,2-diphenylguanidine

Chemical Identifiers

InChI
InChI=1S/C13H13N3/c14-13(15-11-7-3-1-4-8-11)16-12-9-5-2-6-10-12/h1-10H,(H3,14,15,16)
InChI Key
OWRCNXZUPFZXOS-UHFFFAOYSA-N

Overview

1,2-Diphenylguanidine (CAS 102-06-7) is an organic guanidine derivative with accelerating properties used primarily in rubber vulcanization applications. This versatile chemical compound serves as an important intermediate and accelerator in various industrial processes, particularly within the rubber and polymer manufacturing sectors. With its molecular formula C13H13N3 and molecular weight of 211.26 g/mol, 1,2-diphenylguanidine exhibits distinctive chemical properties that make it valuable for specialized applications requiring controlled reaction acceleration. From a safety perspective, this substance requires careful handling due to its classification under multiple hazard categories. It carries reproductive toxicity warnings (Repr. 2), acute toxicity concerns (Acute Tox. 4), and potential for skin and eye irritation. The compound also presents specific target organ toxicity risks and environmental concerns related to aquatic ecosystems. These safety characteristics necessitate appropriate personal protective equipment and controlled handling procedures in industrial settings. The primary industrial applications of 1,2-diphenylguanidine include its use as a vulcanization accelerator in rubber production, where it facilitates cross-linking reactions essential for achieving desired material properties. It also finds application in the synthesis of pharmaceutical intermediates and as a catalyst in certain polymerization processes. In some cases, it may be used alongside other compounds such as 4-aminophenol in specialized chemical synthesis routes. The compound's effectiveness as an accelerator stems from its guanidine functional group, which can participate in various chemical reactions while maintaining stability under typical processing conditions. Its diphenyl substitution pattern provides additional stability and influences its solubility characteristics in different solvent systems. OYSI maintains reliable supply chains for 1,2-diphenylguanidine to support European chemical manufacturing operations requiring this specialized accelerator compound.

Safety & Classification

Warning
Classification:

Repr. 2; Acute Tox. 4 *; STOT SE 3; Skin Irrit. 2; Eye Irrit. 2; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H315

Causes skin irritation.

H319

Causes serious eye irritation.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Irritant

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Name1,3-Diphenylguanidin
Marine PollutantNo

Frequently Asked Questions

What is 1,2-diphenylguanidine?

1,2-diphenylguanidine is an organic chemical compound with the molecular formula C13H13N3 and CAS number 102-06-7. This guanidine derivative has a molecular weight of 211.26 g/mol and appears as a crystalline solid. It belongs to the class of substituted guanidines, characterized by two phenyl groups attached to the guanidine structure. The compound is classified as hazardous with reproductive toxicity category 2 and various health and environmental hazard classifications under the CLP regulation.

What are the physicochemical properties of 1,2-diphenylguanidine?

1,2-diphenylguanidine is typically a white to off-white crystalline solid at room temperature. The compound has limited solubility in water but shows better solubility in organic solvents such as alcohols and aromatic hydrocarbons. It has a molecular weight of 211.26 g/mol and contains nitrogen functional groups that can participate in hydrogen bonding. The compound is stable under normal conditions but may decompose at elevated temperatures, releasing toxic nitrogen oxides.

What is 1,2-diphenylguanidine used for?

1,2-diphenylguanidine is primarily used as a vulcanization accelerator in the rubber industry, particularly for natural and synthetic rubber compounds. It serves as a secondary accelerator in combination with other accelerators to improve vulcanization efficiency and rubber properties. The compound is also utilized in the production of specialty chemicals and as an intermediate in pharmaceutical synthesis. Additionally, it finds applications in the manufacturing of adhesives, sealants, and certain polymer formulations where controlled cross-linking is required.

How to handle 1,2-diphenylguanidine safely?

1,2-diphenylguanidine requires careful handling due to its reproductive toxicity and irritant properties. Wear appropriate personal protective equipment including nitrile gloves, safety goggles, and protective clothing to prevent skin and eye contact. Use respiratory protection in poorly ventilated areas to avoid inhalation. Handle the substance in well-ventilated areas or under local exhaust ventilation. Avoid generating dust and prevent contact with skin, eyes, and clothing. Wash hands thoroughly after handling and before eating or drinking.

How to store 1,2-diphenylguanidine correctly?

1,2-diphenylguanidine should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly closed and protect from moisture to prevent degradation. Store away from incompatible materials such as strong oxidizing agents and acids. Maintain storage temperatures below 25°C when possible. Ensure proper labeling according to CLP regulation and restrict access to authorized personnel only. Use appropriate containment measures to prevent environmental release and follow local storage regulations for hazardous chemicals.

What to do in case of contact with 1,2-diphenylguanidine?

In case of skin contact with 1,2-diphenylguanidine, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air and monitor breathing. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms develop and provide the safety data sheet to medical personnel.

How to dispose of 1,2-diphenylguanidine properly?

1,2-diphenylguanidine must be disposed of as hazardous waste according to local and national regulations. The substance cannot be disposed of with regular industrial waste due to its classification as toxic and harmful to aquatic life. Contact authorized waste disposal companies specialized in chemical waste treatment. Incineration at high temperatures in approved facilities is typically the preferred disposal method. Empty containers should also be treated as hazardous waste. Consult local environmental authorities for specific disposal requirements and waste codes.

How to transport 1,2-diphenylguanidine?

1,2-diphenylguanidine is classified under ADR as Class 6.1 (toxic substances), Packing Group III, indicating moderate toxicity during transport. The substance requires appropriate packaging according to ADR regulations, typically in UN-approved containers with proper marking and labeling. Transport documents must include the correct shipping name, UN number, hazard class, and packing group. Drivers must have appropriate training for hazardous goods transport. Ensure vehicles are properly equipped and follow prescribed transport routes when applicable.

Is 1,2-diphenylguanidine subject to specific regulations?

1,2-diphenylguanidine is subject to REACH regulation requiring registration for manufacture or import above one tonne per year. The substance is classified under CLP regulation with specific hazard classifications including reproductive toxicity category 2. It is not currently listed as a Substance of Very High Concern (SVHC). Companies must provide safety data sheets and ensure proper classification and labeling. Specific national restrictions may apply for certain uses, and workplace exposure limits may be established by individual EU member states.

Where to buy 1,2-diphenylguanidine in Europe?

1,2-diphenylguanidine is available through OYSI, a European distributor of technical chemicals serving various industries across Europe. OYSI provides high-quality chemical products with proper documentation including certificates of analysis and safety data sheets. As a specialized chemical distributor, OYSI ensures compliance with European regulations including REACH and CLP. Contact OYSI directly for availability, technical specifications, packaging options, and delivery throughout Europe. Professional technical support is available to assist with product selection and application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.