Bis(arsenic(3+));tris(oxygen(2-))

As2O3

bis(arsenic(3+));tris(oxygen(2-))

CAS1327-53-3
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
1327-53-3
EC Number
215-481-4
UN Number
1561
Index Number
033-003-00-0
PubChem CID
14888

Physical-chemical properties

Molecular Formula
As2O3
Molar Mass
197.84 g/mol
IUPAC Name
bis(arsenic(3+));tris(oxygen(2-))

Chemical Identifiers

InChI
InChI=1S/2As.3O/q2*+3;3*-2
InChI Key
QTLQKAJBUDWPIB-UHFFFAOYSA-N

Overview

Arsenic trioxide (CAS 1327-53-3) is an inorganic compound with the molecular formula As2O3, characterized by its high toxicity and carcinogenic properties. Arsenic trioxide, also known by its IUPAC name bis(arsenic(3+));tris(oxygen(2-)), is a white crystalline solid with a molecular weight of 197.841 g/mol. This compound represents one of the most significant arsenic compounds in industrial applications, despite its severe health hazards. The substance is classified under multiple hazard categories including Category 1A carcinogen, Category 2 acute toxicity, Category 1B skin corrosion, and poses serious environmental risks to aquatic ecosystems. The compound's dangerous nature is reflected in its GHS classification, requiring pictograms for health hazard (GHS08), acute toxicity (GHS06), corrosion (GHS05), and environmental hazard (GHS09). Transportation regulations classify it under ADR Class 6.1 as a toxic substance, necessitating special handling procedures throughout the supply chain. In industrial applications, arsenic trioxide serves primarily in glass manufacturing as a fining agent to remove bubbles and improve clarity. The electronics industry utilizes it in semiconductor production, while the wood preservation sector employs it in specialized treatments, though environmental concerns have limited this application. The pharmaceutical industry uses highly purified grades in specific cancer treatments, particularly for acute promyelocytic leukemia. Unlike other toxic industrial chemicals such as 2-chloroacetaldehyde or 1-chloro-4-isocyanatobenzene, arsenic trioxide requires exceptional safety protocols due to its carcinogenic properties. OYSI maintains controlled inventory of arsenic trioxide for qualified industrial customers, ensuring full regulatory compliance and proper documentation for this restricted substance.

Safety & Classification

Danger
Classification:

Carc. 1A; Acute Tox. 2 *; Skin Corr. 1B; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H300

Fatal if swallowed.

H314

Causes severe skin burns and eye damage.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Fatal

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1561
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameArsentrioxid
Marine PollutantNo

Frequently Asked Questions

What is bis(arsenic(3+));tris(oxygen(2-))?

Bis(arsenic(3+));tris(oxygen(2-)) is arsenic trioxide (As2O3), a highly toxic inorganic compound with CAS number 1327-53-3. This substance has a molecular weight of 197.841 g/mol and is classified as a Category 1A carcinogen and acute toxicity Category 2 substance. It appears as a white, odorless crystalline powder and is extremely dangerous to human health and the environment.

What are the physicochemical properties of bis(arsenic(3+));tris(oxygen(2-))?

Bis(arsenic(3+));tris(oxygen(2-)) is a white, odorless crystalline solid at room temperature. It has a molecular formula of As2O3 with a molar mass of 197.841 g/mol. The compound is slightly soluble in water and exhibits amphoteric behavior. It sublimes at approximately 193°C and has a melting point around 312°C. Due to its arsenic content, it displays significant toxicological properties.

What is bis(arsenic(3+));tris(oxygen(2-)) used for?

Bis(arsenic(3+));tris(oxygen(2-)) is primarily used in specialized industrial applications including glass manufacturing as a decolorizing agent and in the production of certain pesticides and wood preservatives. It also serves as a raw material for other arsenic compounds and has limited use in some metallurgical processes. Due to its extreme toxicity and carcinogenic properties, its applications are strictly regulated and require specialized handling procedures.

How to handle bis(arsenic(3+));tris(oxygen(2-)) safely?

Bis(arsenic(3+));tris(oxygen(2-)) requires maximum safety precautions during handling due to its carcinogenic and acutely toxic nature. Essential PPE includes full-face respirator with P3 filters, chemical-resistant gloves, protective clothing, and eye protection. Work must be conducted in well-ventilated areas or under fume extraction systems. Avoid any skin contact, inhalation, or ingestion. Emergency shower and eyewash stations must be readily accessible.

How to store bis(arsenic(3+));tris(oxygen(2-)) correctly?

Bis(arsenic(3+));tris(oxygen(2-)) must be stored in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and reducing agents. Use tightly sealed, labeled containers made of appropriate materials. Storage areas should be secured with restricted access due to the substance's extreme toxicity. Implement appropriate containment measures to prevent environmental release and ensure compliance with local hazardous material storage regulations.

What to do in case of contact with bis(arsenic(3+));tris(oxygen(2-))?

Immediate medical attention is crucial for any contact with bis(arsenic(3+));tris(oxygen(2-)) due to its extreme toxicity. For skin contact, remove contaminated clothing and flush with copious amounts of water for at least 15 minutes. If inhaled, move to fresh air immediately. In case of eye contact, rinse thoroughly with water. Never induce vomiting if ingested. Contact emergency services and provide the safety data sheet to medical personnel.

How to dispose of bis(arsenic(3+));tris(oxygen(2-)) appropriately?

Bis(arsenic(3+));tris(oxygen(2-)) must be disposed of as hazardous waste through licensed waste management companies specializing in toxic and carcinogenic materials. Never dispose of this substance in regular waste streams, sewers, or the environment. Disposal must comply with local, national, and EU hazardous waste regulations. Contact certified hazardous waste contractors for proper collection, treatment, and disposal procedures to prevent environmental contamination.

How to transport bis(arsenic(3+));tris(oxygen(2-))?

Bis(arsenic(3+));tris(oxygen(2-)) is classified under ADR Class 6.1 (toxic substances) Packing Group II, requiring specialized hazardous materials transportation. Packages must be properly labeled with GHS pictograms (GHS08, GHS06, GHS05, GHS09) and transport documentation must include proper shipping names and hazard classifications. Only trained personnel and certified carriers should handle transportation, following strict ADR regulations for toxic substances.

Is bis(arsenic(3+));tris(oxygen(2-)) subject to specific regulations?

Bis(arsenic(3+));tris(oxygen(2-)) is subject to extensive regulatory oversight under REACH, CLP, and national legislation due to its carcinogenic and toxic properties. It requires safety data sheets, proper classification and labeling according to CLP regulation, and may be subject to authorization or restriction procedures. Users must comply with occupational exposure limits, environmental protection measures, and reporting requirements for carcinogenic substances in the workplace.

Where to buy bis(arsenic(3+));tris(oxygen(2-)) in Europe?

Bis(arsenic(3+));tris(oxygen(2-)) is available through specialized chemical distributors like OYSI, which serves the European market with technical-grade chemicals. Due to its extreme toxicity and regulatory requirements, purchases are typically restricted to qualified industrial users with appropriate handling capabilities and regulatory compliance. Contact OYSI's technical team for availability, specifications, and regulatory guidance for this highly controlled substance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.