Benzene-1,2-diamine

C6H8N2

benzene-1,2-diamine

CAS95-54-5
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

Consulting for Benzene-1,2-diamine

Our experts support you with application, dosage, and compliance.

Request Consultation

Identification

CAS Number
95-54-5
EC Number
202-430-6
UN Number
1673
Index Number
612-145-00-2
PubChem CID
7243

Physical-chemical properties

Molecular Formula
C6H8N2
Molar Mass
108.14 g/mol
IUPAC Name
benzene-1,2-diamine

Chemical Identifiers

InChI
InChI=1S/C6H8N2/c7-5-3-1-2-4-6(5)8/h1-4H,7-8H2
InChI Key
GEYOCULIXLDCMW-UHFFFAOYSA-N

Overview

Benzene-1,2-diamine (CAS 95-54-5) is an aromatic diamine compound with two amino groups in ortho position on the benzene ring. Benzene-1,2-diamine, also known as o-phenylenediamine, is a crystalline organic compound with the molecular formula C6H8N2 and a molecular weight of 108.14 g/mol. This aromatic diamine features two amino groups (-NH2) positioned adjacently on a benzene ring, which gives it unique chemical reactivity and makes it a valuable intermediate in various chemical synthesis processes. The compound presents significant safety considerations due to its classification profile. It is classified as a Category 2 carcinogen and mutagen, requiring careful handling protocols in industrial applications. Additionally, it exhibits acute toxicity through multiple exposure routes and can cause eye irritation and skin sensitization. The substance is also classified as hazardous to the aquatic environment, necessitating appropriate containment and disposal measures. From a chemical perspective, benzene-1,2-diamine belongs to the same family as other aromatic amines such as N-methylaniline, sharing similar reactivity patterns due to the presence of amino groups attached to aromatic systems. The ortho positioning of the amino groups enables the formation of chelating complexes and facilitates cyclization reactions, distinguishing it from other isomeric diamines. Primary industrial applications include its use as an intermediate in the synthesis of dyes and pigments, particularly in the production of azo dyes where its diamine functionality provides reactive sites for coupling reactions. It also serves as a building block in polymer chemistry for creating specialized materials and finds application in the pharmaceutical industry as an intermediate for drug synthesis. OYSI provides benzene-1,2-diamine to European industrial customers with comprehensive technical documentation and safety data sheets to ensure compliant handling and application.

Safety & Classification

Danger
Classification:

Carc. 2; Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aqu...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H341

Suspected of causing genetic defects.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1673
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Nameo-Phenylendiamin, fest
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,2-diamine?

Benzene-1,2-diamine is an aromatic organic compound with the molecular formula C6H8N2 and CAS number 95-54-5. This chemical consists of a benzene ring with two amino groups (-NH2) attached to adjacent carbon atoms in positions 1 and 2. With a molecular weight of 108.14 g/mol, it belongs to the diamine family of compounds and is classified as a hazardous substance with carcinogenic and mutagenic properties.

What are the physicochemical properties of benzene-1,2-diamine?

Benzene-1,2-diamine appears as crystalline solid at room temperature, typically exhibiting a brownish to dark color due to oxidation. The compound has a characteristic amine-like odor and shows good solubility in water and polar organic solvents. It has a tendency to darken upon exposure to air and light due to oxidation reactions, which affects its stability during storage and handling.

What is benzene-1,2-diamine used for?

Benzene-1,2-diamine serves primarily as an intermediate in the synthesis of dyes, pigments, and polymers in industrial applications. It is commonly used in the production of benzimidazole compounds, pharmaceutical intermediates, and as a curing agent for epoxy resins. The compound also finds application in the manufacture of antioxidants and corrosion inhibitors for various industrial processes.

How to handle benzene-1,2-diamine safely?

Benzene-1,2-diamine requires strict safety measures including wearing chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Workers must use full personal protective equipment due to its carcinogenic and mutagenic classification. Avoid direct skin contact and inhalation, work under fume hoods when possible, and ensure emergency eyewash stations and safety showers are readily accessible during handling operations.

How to store benzene-1,2-diamine correctly?

Benzene-1,2-diamine must be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Keep containers away from oxidizing agents and strong acids to prevent dangerous reactions. Store in original labeled containers with appropriate secondary containment, and maintain storage areas with controlled access due to the substance's hazardous classification.

What to do in case of contact with benzene-1,2-diamine?

Benzene-1,2-diamine exposure requires immediate action: for skin contact, rinse thoroughly with water for at least 15 minutes and remove contaminated clothing. In case of eye contact, flush with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult emergency services for any exposure incidents.

How to dispose of benzene-1,2-diamine appropriately?

Benzene-1,2-diamine disposal must comply with local and European waste regulations as a hazardous substance. The compound requires treatment as special waste and cannot be disposed of through regular waste streams. Contact licensed waste disposal companies specialized in handling carcinogenic materials. Neutralization or incineration at appropriate high-temperature facilities under controlled conditions is typically required for proper disposal.

How to transport benzene-1,2-diamine?

Benzene-1,2-diamine is classified under ADR Class 6.1 (toxic substances) Packing Group III for transportation. The substance requires appropriate UN-specification packaging with proper labeling including GHS pictogramms GHS08, GHS06, and GHS09. Transport documentation must include proper shipping names, hazard classifications, and emergency response information. Only authorized carriers experienced in hazardous material transport should handle shipments.

Is benzene-1,2-diamine subject to specific regulations?

Benzene-1,2-diamine is subject to comprehensive European regulations including REACH registration requirements and CLP classification as Carcinogenic Category 2 and Mutagenic Category 2. The substance requires safety data sheets, exposure scenario documentation, and worker protection measures under occupational health regulations. Users must comply with chemical safety assessments and may face restrictions on certain applications due to its hazardous classification.

Where to buy benzene-1,2-diamine in Europe?

Benzene-1,2-diamine is available through OYSI, a specialized European distributor of technical chemicals with expertise in hazardous substance supply. OYSI provides proper documentation, safety data sheets, and regulatory compliance support for industrial customers across Europe. As an established chemical distributor, OYSI ensures appropriate packaging, labeling, and transport arrangements for this regulated substance while maintaining full traceability and quality standards.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.