Aniline;hydrochloride
C6H8ClN
aniline;hydrochloride
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Identification
- CAS Number
- 142-04-1
- EC Number
- 205-519-8
- UN Number
- 1548
- Index Number
- 612-009-00-2
- PubChem CID
- 8870
Physical-chemical properties
- Molecular Formula
- C6H8ClN
- Molar Mass
- 129.59 g/mol
- IUPAC Name
- aniline;hydrochloride
Chemical Identifiers
- InChI
- InChI=1S/C6H7N.ClH/c7-6-4-2-1-3-5-6;/h1-5H,7H2;1H
- InChI Key
- MMCPOSDMTGQNKG-UHFFFAOYSA-N
Overview
Aniline hydrochloride (CAS 142-04-1) is an aromatic amine salt with high solubility in water and significant industrial applications. This crystalline compound, with the molecular formula C6H8ClN and a molar mass of 129.59 g/mol, represents the hydrochloride salt form of aniline, offering enhanced stability and handling characteristics compared to its free base counterpart. As a white to pale yellow crystalline powder, aniline hydrochloride serves as a crucial intermediate in numerous chemical synthesis processes across various industrial sectors. The compound exhibits significant hazard classifications under CLP regulation, including carcinogenicity (Category 2), mutagenicity (Category 2), and acute toxicity (Category 3) through multiple exposure routes. Its classification as STOT RE 1 indicates specific target organ toxicity following repeated exposure, while its eye damage and skin sensitization properties necessitate stringent safety protocols during handling and storage. The presence of GHS pictograms 08, 06, 05, and 09 on safety data sheets reflects these serious health and environmental hazards, requiring appropriate personal protective equipment and engineering controls. In industrial applications, aniline hydrochloride functions primarily as an intermediate in pharmaceutical manufacturing, particularly in the synthesis of analgesics and other therapeutic compounds. The dye and pigment industry utilizes this compound for producing various colorants, while it also serves as a precursor in rubber chemical production. Unlike related compounds such as 1-chloro-4-isocyanatobenzene, which is used in polyurethane applications, aniline hydrochloride's primary value lies in its role as a stable, water-soluble form of aniline that facilitates specific synthetic pathways. Transportation under ADR Class 6.1 classification requires specialized handling procedures to ensure compliance with hazardous materials regulations. OYSI provides aniline hydrochloride to qualified industrial customers with comprehensive safety documentation and technical support.
Safety & Classification
Carc. 2; Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 1; Eye Dam. 1; Skin Sen...
GHS Pictograms
Health Hazard
GHS08
Serious health hazard. May cause cancer, organ damage, or genetic defects.
Skull and Crossbones
GHS06
Acute toxicity. Fatal if swallowed, in contact with skin, or if inhaled.
Corrosion
GHS05
Corrosive. Causes severe skin burns and eye damage.
Environment
GHS09
Environmental hazard. Toxic to aquatic life with long lasting effects.
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Suspected of causing cancer.
Suspected of causing genetic defects.
Toxic if inhaled.
Toxic in contact with skin.
Toxic if swallowed.
Causes damage to organs through prolonged or repeated exposure.
Causes serious eye damage.
May cause an allergic skin reaction.
Very toxic to aquatic life.
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 1548 |
| ADR Class | 6.1 |
| Packing Group | III |
| Tunnel Code | E |
| Proper Shipping Name | Anilinhydrochlorid |
| Marine Pollutant | No |
Frequently Asked Questions
What is aniline hydrochloride?
Aniline hydrochloride is the hydrochloride salt of aniline, a primary aromatic amine compound with the molecular formula C6H8ClN and CAS number 142-04-1. This white crystalline solid has a molecular weight of 129.59 g/mol and is classified as a dangerous substance with multiple hazard classifications including carcinogenicity, mutagenicity, and acute toxicity. It is commonly used as an intermediate in chemical synthesis and dye manufacturing.
What are the physicochemical properties of aniline hydrochloride?
Aniline hydrochloride is a white to off-white crystalline solid that is highly soluble in water and polar solvents. The compound is stable under normal conditions but may decompose when heated, releasing toxic gases including hydrogen chloride and nitrogen oxides. It has a characteristic amine-like odor and is hygroscopic, meaning it absorbs moisture from air. The salt form makes it more stable and easier to handle than free aniline.
What is aniline hydrochloride used for?
Aniline hydrochloride is primarily used as an intermediate in the synthesis of dyes, pharmaceuticals, and other organic compounds. It serves as a starting material for producing various aniline derivatives, antioxidants, and rubber chemicals. The compound is also utilized in analytical chemistry as a reagent and in the manufacture of photographic chemicals. Its applications are mainly restricted to industrial and professional use due to its hazardous classification.
How to handle aniline hydrochloride safely?
Aniline hydrochloride requires strict safety measures including wearing appropriate personal protective equipment: chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact, and prevent dust generation during handling. Given its carcinogenic and mutagenic properties (Carc. 2, Muta. 2), minimize exposure time and follow occupational exposure limits strictly.
How to store aniline hydrochloride correctly?
Aniline hydrochloride should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep away from incompatible materials such as strong oxidizing agents, acids, and bases. Store in original labeled containers with appropriate hazard warnings. Ensure storage areas have adequate ventilation and emergency equipment. Access should be restricted to trained personnel only due to the substance's hazardous nature.
What to do in case of contact with aniline hydrochloride?
Aniline hydrochloride exposure requires immediate action: for skin contact, remove contaminated clothing and wash thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes and remove contact lenses if present. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention immediately. Always consult a physician after any exposure incident.
How to dispose of aniline hydrochloride appropriately?
Aniline hydrochloride disposal must comply with local and national hazardous waste regulations as it is classified as toxic waste. The substance cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment facilities. Contact licensed waste disposal companies for proper collection and treatment. Small quantities should be neutralized and disposed of according to regulatory guidelines. Never discharge into sewers, waterways, or soil.
How to transport aniline hydrochloride?
Aniline hydrochloride is classified under ADR Class 6.1 (toxic substances), Packaging Group III for transportation. It requires appropriate UN specification packaging with proper labeling including GHS pictograms (GHS08, GHS06, GHS05, GHS09) and hazard warnings. Transport documents must include the correct shipping name, UN number, and emergency response information. Only authorized carriers experienced in handling toxic materials should transport this substance, following all ADR regulations.
Is aniline hydrochloride subject to specific regulations?
Aniline hydrochloride is subject to extensive regulatory oversight under REACH, CLP, and various national chemical regulations due to its hazardous properties. It requires safety data sheets, hazard classification labeling, and may be subject to authorization or restriction procedures. The substance falls under occupational health regulations requiring exposure monitoring and health surveillance. Companies handling this chemical must comply with industrial emissions directives and waste management regulations.
Where to buy aniline hydrochloride in Europe?
Aniline hydrochloride is available through OYSI, a specialized European distributor of technical chemicals with expertise in hazardous substances. OYSI provides proper documentation, safety data sheets, and regulatory compliance support for professional and industrial customers. As a controlled substance requiring specialized handling, it is only available to qualified industrial users with appropriate safety facilities and trained personnel. Contact OYSI for availability and technical specifications.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.