Benzene-1,2-diamine;dihydrochloride

C6H10Cl2N2

benzene-1,2-diamine;dihydrochloride

CAS615-28-1
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
615-28-1
EC Number
210-418-7
UN Number
2811
Index Number
612-146-00-8
PubChem CID
11990

Physical-chemical properties

Molecular Formula
C6H10Cl2N2
Molar Mass
181.06 g/mol
IUPAC Name
benzene-1,2-diamine;dihydrochloride

Chemical Identifiers

InChI
InChI=1S/C6H8N2.2ClH/c7-5-3-1-2-4-6(5)8;;/h1-4H,7-8H2;2*1H
InChI Key
RIIWUGSYXOBDMC-UHFFFAOYSA-N

Overview

Benzene-1,2-diamine;dihydrochloride (CAS 615-28-1) is an aromatic diamine salt with significant industrial applications and notable safety considerations. This crystalline compound, also known by its IUPAC designation benzene-1,2-diamine;dihydrochloride, represents the dihydrochloride salt form of ortho-phenylenediamine. With a molecular formula of C6H10Cl2N2 and molecular weight of 181.06 g/mol, this chemical belongs to the aromatic amine family and shares structural similarities with related compounds such as benzene-1,2-diamine and other substituted anilines like N-methylaniline. The compound exhibits substantial hazard classifications requiring careful handling protocols. It carries multiple danger classifications including carcinogenicity (Category 2), mutagenicity (Category 2), acute toxicity, eye irritation, and skin sensitization properties. The presence of GHS08, GHS06, and GHS09 pictograms indicates health hazards, acute toxicity, and environmental concerns respectively. Its ADR classification of 6.1 designates it as a toxic substance for transportation purposes. From an industrial perspective, benzene-1,2-diamine;dihydrochloride serves primarily in chemical synthesis applications, particularly in the production of dyes, pigments, and specialty chemical intermediates. The compound also finds use in pharmaceutical intermediate synthesis and as a building block for various organic compounds. Its salt form provides enhanced stability and handling characteristics compared to the free base. Given its hazardous nature, proper safety equipment, ventilation systems, and trained personnel are essential when working with this material. Storage requirements must comply with regulations for toxic and potentially carcinogenic substances. OYSI maintains availability of benzene-1,2-diamine;dihydrochloride for qualified industrial customers with appropriate safety and handling capabilities.

Safety & Classification

Danger
Classification:

Carc. 2; Muta. 2; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aqu...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H351

Suspected of causing cancer.

H341

Suspected of causing genetic defects.

H332

Harmful if inhaled.

H312

Harmful in contact with skin.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Harmful

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameBenzen-1,2-diamin-dihydrochlorid
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,2-diamine;dihydrochloride?

Benzene-1,2-diamine;dihydrochloride is an organic chemical compound with the molecular formula C6H10Cl2N2 and CAS number 615-28-1. This substance is the dihydrochloride salt form of ortho-phenylenediamine, featuring two amino groups attached to adjacent carbon atoms on a benzene ring. With a molecular weight of 181.06 g/mol, it is classified as a hazardous substance with carcinogenic and mutagenic properties, requiring careful handling and specialized safety measures in industrial applications.

What are the physicochemical properties of benzene-1,2-diamine;dihydrochloride?

Benzene-1,2-diamine;dihydrochloride is typically a crystalline solid at room temperature due to its salt structure. As a dihydrochloride salt, it exhibits enhanced water solubility compared to its free base form, making it more suitable for aqueous applications. The compound's physical appearance and specific properties like melting point, density, and vapor pressure depend on purity and crystalline form. Its chemical stability can be affected by light, heat, and oxidizing conditions, requiring appropriate storage considerations.

What is benzene-1,2-diamine;dihydrochloride used for?

Benzene-1,2-diamine;dihydrochloride is primarily used as an intermediate in chemical synthesis and manufacturing processes. It serves as a precursor for producing dyes, pigments, and polymer materials. The compound finds applications in the pharmaceutical industry for synthesizing certain drug compounds and in the production of specialty chemicals. Due to its hazardous classification, its use is restricted to professional industrial settings with appropriate safety controls and regulatory compliance measures in place.

How to handle benzene-1,2-diamine;dihydrochloride safely?

Benzene-1,2-diamine;dihydrochloride requires strict safety protocols due to its carcinogenic and mutagenic properties. Personal protective equipment must include chemical-resistant gloves, safety goggles, and respiratory protection when handling. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Skin and eye contact must be avoided completely. Only trained personnel should handle this substance, following established safety procedures and maintaining emergency response protocols for potential exposure incidents.

How to store benzene-1,2-diamine;dihydrochloride correctly?

Benzene-1,2-diamine;dihydrochloride should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. The storage area must be secured and accessible only to authorized personnel due to the substance's hazardous nature. Keep away from incompatible materials such as strong oxidizers and acids. Storage facilities should comply with local regulations for carcinogenic substances and include appropriate containment measures to prevent environmental contamination in case of spills.

What to do in case of contact with benzene-1,2-diamine;dihydrochloride?

Immediate action is required for any contact with benzene-1,2-diamine;dihydrochloride. For skin contact, remove contaminated clothing and rinse affected area with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure incident and provide the safety data sheet.

How to dispose of benzene-1,2-diamine;dihydrochloride appropriately?

Benzene-1,2-diamine;dihydrochloride must be disposed of as hazardous waste through licensed waste management facilities specializing in toxic chemical disposal. The substance cannot be disposed of in regular waste streams or sewage systems due to its carcinogenic properties and environmental hazard classification. Disposal must comply with local, national, and EU waste regulations including proper documentation and tracking. Empty containers should also be treated as hazardous waste and disposed of through appropriate channels to prevent environmental contamination.

How to transport benzene-1,2-diamine;dihydrochloride?

Benzene-1,2-diamine;dihydrochloride is classified under ADR Class 6.1 (toxic substances) Packing Group III for transportation purposes. Packages must be properly labeled with appropriate hazard markings and GHS pictograms (GHS08, GHS06, GHS09). Transportation requires compliance with dangerous goods regulations including proper packaging, documentation, and vehicle requirements. Only certified carriers experienced in handling toxic chemicals should transport this substance, ensuring proper emergency response capabilities and adherence to routing restrictions where applicable.

Is benzene-1,2-diamine;dihydrochloride subject to special regulations?

Benzene-1,2-diamine;dihydrochloride is subject to extensive regulatory oversight under EU CLP regulation due to its carcinogenic and mutagenic classification. The substance falls under REACH registration requirements for manufacturing and import. While not currently listed as an SVHC, its hazardous properties require compliance with occupational exposure limits and workplace safety regulations. Users must maintain proper safety data sheets, conduct risk assessments, and implement appropriate risk management measures as mandated by chemical safety legislation.

Where to buy benzene-1,2-diamine;dihydrochloride in Europe?

Benzene-1,2-diamine;dihydrochloride is available through OYSI, a specialized European distributor of technical chemicals serving professional industrial customers. As a regulated hazardous substance, purchase is restricted to qualified industrial users who can demonstrate appropriate handling capabilities and regulatory compliance. OYSI provides technical support and documentation required for safe handling and regulatory compliance. Customers must meet strict qualification criteria and provide proper credentials for procurement of this controlled chemical substance through authorized distribution channels.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.