Benzene-1,3-diamine

C6H8N2

benzene-1,3-diamine

CAS108-45-2
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
108-45-2
EC Number
203-584-7
UN Number
1673
Index Number
612-147-00-3
PubChem CID
7935

Physical-chemical properties

Molecular Formula
C6H8N2
Molar Mass
108.14 g/mol
IUPAC Name
benzene-1,3-diamine

Chemical Identifiers

InChI
InChI=1S/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H2
InChI Key
WZCQRUWWHSTZEM-UHFFFAOYSA-N

Overview

Benzene-1,3-diamine (CAS 108-45-2) is an aromatic diamine compound with two amino groups positioned at the 1,3-positions on the benzene ring. This organic chemical intermediate, also known by its IUPAC designation benzene-1,3-diamine, represents a crucial building block in various industrial synthesis processes. With the molecular formula C6H8N2 and a molecular weight of 108.14 g/mol, this aromatic diamine exhibits the characteristic reactivity of primary amine groups combined with the stability of an aromatic ring system. The compound's structure, featuring amino groups in meta positions, provides unique chemical properties that distinguish it from other diamine isomers and related compounds such as N-methylaniline. The substance requires careful handling protocols due to its significant safety profile. Classified under ADR Class 6.1 and bearing the "Danger" signal word, benzene-1,3-diamine presents multiple hazard categories including mutagenicity (Category 2), acute toxicity (Category 3), eye irritation, skin sensitization, and aquatic toxicity. The associated GHS pictograms GHS08, GHS06, and GHS09 reflect these health, acute toxicity, and environmental hazards respectively. Proper personal protective equipment and ventilation systems are essential when working with this material. Industrial applications of benzene-1,3-diamine center primarily on polymer synthesis and specialty chemical manufacturing. The compound serves as a key intermediate in the production of polyurethanes, epoxy curing agents, and various dye intermediates. Its dual amino functionality makes it particularly valuable in cross-linking applications and as a hardener component in advanced materials formulations. OYSI provides reliable access to benzene-1,3-diamine for qualified industrial customers throughout Europe, ensuring consistent quality and regulatory compliance for demanding technical applications.

Safety & Classification

Danger
Classification:

Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acut...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H341

Suspected of causing genetic defects.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1673
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Namem-Phenylendiamin, fest
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,3-diamine?

Benzene-1,3-diamine is an organic chemical compound with the molecular formula C6H8N2 and CAS number 108-45-2. This aromatic diamine consists of a benzene ring with two amino groups (-NH2) positioned at the 1 and 3 positions. With a molecular weight of 108.14 g/mol, it belongs to the class of phenylenediamines and is classified as a hazardous substance with mutagenic properties and acute toxicity.

What are the physicochemical properties of benzene-1,3-diamine?

Benzene-1,3-diamine appears as crystalline solid at room temperature, typically white to light brown in color. The compound has a characteristic amine-like odor and exhibits good solubility in water and polar organic solvents. Its aromatic structure with two amino groups makes it highly reactive, particularly in oxidation reactions. The substance tends to darken upon exposure to air and light due to oxidation processes.

What is benzene-1,3-diamine used for?

Benzene-1,3-diamine is primarily used as an intermediate in the production of polymers, particularly aramid fibers and high-performance plastics. It serves as a key raw material in manufacturing specialty chemicals, dyes, and pharmaceutical intermediates. The compound is also utilized in the production of corrosion inhibitors, antioxidants, and as a curing agent for epoxy resins in industrial applications.

How to handle benzene-1,3-diamine safely?

Benzene-1,3-diamine requires careful handling due to its acute toxicity and mutagenic properties. Personal protective equipment must include chemical-resistant gloves, safety goggles, and respiratory protection when handling powders or in poorly ventilated areas. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin contact and inhalation, as the substance can cause skin sensitization and is harmful if absorbed through skin.

How to store benzene-1,3-diamine correctly?

Benzene-1,3-diamine should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. The storage area must be separate from incompatible materials such as strong oxidizers and acids. Containers should be kept in secondary containment to prevent environmental release. Temperature should be maintained below 25°C to prevent degradation and ensure product stability.

What to do in case of contact with benzene-1,3-diamine?

Benzene-1,3-diamine exposure requires immediate action due to its toxicity. In case of skin contact, immediately wash with plenty of water for at least 15 minutes and remove contaminated clothing. For eye contact, rinse thoroughly with water and seek immediate medical attention. If inhaled, move to fresh air and seek medical attention if breathing difficulties occur. Never induce vomiting if ingested - seek immediate medical care.

How to dispose of benzene-1,3-diamine properly?

Benzene-1,3-diamine disposal must comply with local hazardous waste regulations due to its toxic and potentially mutagenic properties. The substance cannot be disposed of in regular waste streams and requires treatment at licensed hazardous waste facilities. Small quantities should be collected in appropriate containers and labeled for hazardous waste collection. Incineration at high temperatures in specialized facilities is typically the preferred disposal method.

How to transport benzene-1,3-diamine?

Benzene-1,3-diamine is classified under ADR Class 6.1 (Toxic substances), Packing Group III for transportation. Packages must be properly labeled with appropriate hazard pictograms (GHS06, GHS08, GHS09) and the "Danger" signal word. Transportation requires compliance with dangerous goods regulations, including proper packaging, documentation, and vehicle requirements. Only certified carriers experienced in hazardous materials transport should handle shipments.

Is benzene-1,3-diamine subject to specific regulations?

Benzene-1,3-diamine is subject to comprehensive chemical regulations including REACH registration requirements in the European Union and CLP classification obligations. The substance is classified as Muta. 2, Acute Tox. 3, Eye Irrit. 2, Skin Sens. 1, and poses aquatic toxicity concerns. While not currently listed as an SVHC, its mutagenic classification means it faces strict handling, labeling, and documentation requirements under chemical safety legislation.

Where to buy benzene-1,3-diamine in Europe?

Benzene-1,3-diamine is available through OYSI, a European distributor specializing in technical chemicals. As an established chemical distributor, OYSI provides reliable supply chains across European markets with proper documentation and regulatory compliance. Due to the substance's hazardous classification, purchases typically require qualification as a professional user and compliance with local regulations regarding storage, handling, and end-use applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.