Benzene-1,3-diamine

C6H8N2

benzene-1,3-diamine

CAS108-45-2
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
108-45-2
EC Number
203-584-7
UN Number
1673
Index Number
612-147-00-3
PubChem CID
7935

Physical-chemical properties

Molecular Formula
C6H8N2
Molar Mass
108.14 g/mol
IUPAC Name
benzene-1,3-diamine

Chemical Identifiers

InChI
InChI=1S/C6H8N2/c7-5-2-1-3-6(8)4-5/h1-4H,7-8H2
InChI Key
WZCQRUWWHSTZEM-UHFFFAOYSA-N

Overview

Benzene-1,3-diamine (CAS 108-45-2) is an aromatic diamine compound with two amino groups positioned meta to each other on the benzene ring. This organic chemical intermediate, also known by its IUPAC designation benzene-1,3-diamine, represents a crucial building block in various industrial synthesis processes. With a molecular formula of C6H8N2 and molecular weight of 108.14 g/mol, this crystalline compound exhibits the characteristic reactivity of aromatic amines while maintaining distinct properties due to its meta-substitution pattern. The presence of two amino groups in the 1,3-positions provides unique chemical versatility for polymerization reactions and chemical modifications. Benzene-1,3-diamine requires careful handling due to its classification under multiple hazard categories, including mutagenicity (Category 2) and acute toxicity (Category 3). The compound displays skin sensitization properties and eye irritation potential, necessitating appropriate personal protective equipment and controlled work environments. Its ADR classification as Class 6.1 reflects its toxic nature during transportation and storage. The compound finds primary applications in polymer chemistry, particularly in the production of polyamides and polyimides where its meta-positioned amino groups contribute to enhanced thermal stability and mechanical properties. It serves as an important curing agent for epoxy resins and as an intermediate in pharmaceutical synthesis. Related compounds in this chemical family include N-methylaniline and phenylhydrazine, which share similar aromatic amine characteristics but offer different reactivity profiles for specialized applications. OYSI provides benzene-1,3-diamine to European industrial customers requiring high-quality aromatic diamine intermediates for their manufacturing processes.

Safety & Classification

Danger
Classification:

Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Eye Irrit. 2; Skin Sens. 1; Aquatic Acut...

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H341

Suspected of causing genetic defects.

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H319

Causes serious eye irritation.

H317

May cause an allergic skin reaction.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1673
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping Namem-Phenylendiamin, fest
Marine PollutantNo

Frequently Asked Questions

What is benzene-1,3-diamine?

Benzene-1,3-diamine is an aromatic organic compound with the molecular formula C6H8N2 and CAS number 108-45-2. This chemical consists of a benzene ring with two amino groups (-NH2) attached at the 1 and 3 positions, making it an isomer of phenylenediamine. With a molecular weight of 108.14 g/mol, it appears as crystalline solid and is classified as a hazardous substance requiring careful handling due to its mutagenic and toxic properties.

What are the physicochemical properties of benzene-1,3-diamine?

Benzene-1,3-diamine is a crystalline solid at room temperature, typically appearing as white to light brown crystals that may darken upon exposure to air and light. The compound is moderately soluble in water and readily dissolves in alcohols and other polar solvents. It has a characteristic amine-like odor and tends to be hygroscopic, absorbing moisture from the atmosphere. The melting point is around 63°C, and it exhibits basic properties due to the presence of amino groups.

What is benzene-1,3-diamine used for?

Benzene-1,3-diamine is primarily used as an intermediate in the production of polymers, particularly polyamides and polyimides. It serves as a crucial building block in the manufacture of high-performance materials, adhesives, and coating resins. The compound is also utilized in the synthesis of dyes, pigments, and pharmaceutical intermediates. Additionally, it finds applications in the production of corrosion inhibitors and as a curing agent for epoxy resins in specialized industrial applications.

How to handle benzene-1,3-diamine safely?

Benzene-1,3-diamine requires strict safety measures due to its mutagenic and toxic properties. Personal protective equipment must include chemical-resistant gloves, safety goggles, and respiratory protection to prevent inhalation exposure. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin and eye contact, and prevent dust formation during handling. Regular monitoring of workplace air quality is recommended, and workers should be trained in proper handling procedures and emergency response protocols.

How to store benzene-1,3-diamine correctly?

Benzene-1,3-diamine must be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight. The storage area should be equipped with appropriate ventilation systems and spill containment measures. Keep containers tightly sealed to prevent moisture absorption and contamination. Store separately from oxidizing agents, acids, and incompatible materials. Access should be restricted to trained personnel, and the storage area must comply with local regulations for hazardous chemicals.

What to do in case of contact with benzene-1,3-diamine?

Immediate action is required in case of contact with benzene-1,3-diamine. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move the person to fresh air and seek medical attention if breathing difficulties occur. For ingestion, do not induce vomiting and seek immediate medical assistance.

How to dispose of benzene-1,3-diamine properly?

Benzene-1,3-diamine must be disposed of as hazardous waste through licensed waste management companies in accordance with local and European regulations. The substance cannot be discharged to sewers, waterways, or regular waste streams due to its toxic and mutagenic properties. Waste containers should be properly labeled and stored in designated areas until collection. Incineration at high temperatures in specialized facilities is typically the preferred disposal method, following all applicable environmental protection standards.

How to transport benzene-1,3-diamine?

Benzene-1,3-diamine is classified under ADR Class 6.1 (toxic substances), Packing Group III for transportation purposes. The substance must be packaged in UN-approved containers with appropriate labeling including GHS pictograms (GHS06, GHS08, GHS09) and the danger signal word. Transport vehicles must carry proper documentation, emergency response information, and comply with routing restrictions. Drivers require ADR certification, and the shipment must follow all applicable dangerous goods regulations for road transport within Europe.

Is benzene-1,3-diamine subject to particular regulations?

Benzene-1,3-diamine is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification standards. The substance is classified as Muta. 2, Acute Tox. 3, Eye Irrit. 2, Skin Sens. 1, and Aquatic Acute toxicity under CLP regulation. While not currently listed as a SVHC (Substance of Very High Concern), its mutagenic properties require strict compliance with occupational exposure limits, worker protection measures, and environmental release controls throughout the supply chain.

Where to buy benzene-1,3-diamine in Europe?

Benzene-1,3-diamine is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across the continent. OYSI provides compliant packaging, proper documentation, and technical support for this regulated substance. As a professional chemical distributor, OYSI ensures full regulatory compliance including REACH requirements and proper classification. Contact OYSI directly to discuss specific requirements, quantities, and delivery options for benzene-1,3-diamine to your European location while meeting all safety and regulatory standards.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.