4-chloroaniline

4-chloroaniline is an aromatic amine compound with the chemical formula C6H6ClN and CAS number 106-47-8. It consists of an aniline molecule with a chlorine atom substituted at the para position (4th carbon) of the benzene ring. With a molecular weight of 127.57 g/mol, this chemical is classified as a carcinogenic substance (Carc. 1B) and presents significant toxicity risks. It appears as a crystalline solid and is primarily used as an intermediate in chemical synthesis processes.

4-chloroaniline is a crystalline solid at room temperature, typically appearing as white to light yellow crystals or powder. It has a molecular weight of 127.57 g/mol and contains both amino and chloro functional groups. The compound is moderately soluble in organic solvents but has limited water solubility. It exhibits basic properties due to the amino group and can form salts with acids. The presence of the chlorine substituent affects its reactivity compared to unsubstituted aniline.

4-chloroaniline serves primarily as an intermediate in pharmaceutical and chemical synthesis. It is used in the production of dyes, pigments, and various organic compounds. The compound acts as a building block for manufacturing pharmaceuticals, agrochemicals, and specialty chemicals. Its aromatic amine structure makes it valuable for creating azo dyes and other colored compounds. Due to its carcinogenic classification, its use is strictly regulated and limited to professional industrial applications with appropriate safety controls.

4-chloroaniline requires extreme caution during handling due to its carcinogenic and toxic properties. Personal protective equipment must include chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas or fume hoods. Avoid skin contact, inhalation, and ingestion completely. Work in designated areas with appropriate engineering controls. Use only in closed systems when possible. All personnel must receive specific training on carcinogen handling procedures and emergency response protocols before working with this substance.

4-chloroaniline must be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed in original packaging, protected from light and moisture. Store separately from oxidizing agents, strong acids, and bases to prevent dangerous reactions. The storage area should be restricted to authorized personnel only, with appropriate warning signs indicating carcinogenic hazards. Implement secondary containment measures and maintain storage temperature below manufacturer specifications to ensure chemical stability.

Immediate action is required for any contact with 4-chloroaniline. For skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately and seek medical attention. For eye contact, rinse with clean water for at least 15 minutes and remove contact lenses if present. Never induce vomiting if ingested. Seek immediate medical attention in all exposure cases and inform healthcare providers about the carcinogenic nature of the substance.

4-chloroaniline disposal requires compliance with hazardous waste regulations due to its carcinogenic classification. Contact licensed hazardous waste disposal companies for proper treatment and destruction. Never dispose of this substance through regular waste streams or sewage systems. Incineration at high temperatures in specialized facilities is typically required. Keep detailed records of all disposal activities as required by local and European regulations. Empty containers must also be treated as hazardous waste and disposed of according to regulatory requirements.

4-chloroaniline is classified under ADR transport regulations as Class 6.1 (toxic substances), Packing Group II, indicating significant toxicity hazards. Transportation requires specialized packaging, proper labeling with GHS pictograms (GHS06, GHS08, GHS09), and documentation indicating the carcinogenic nature. Only authorized carriers with appropriate permits and training should handle transport. Vehicles must carry appropriate emergency equipment and safety data sheets. Segregation from incompatible materials during transport is mandatory to prevent dangerous reactions.

4-chloroaniline is heavily regulated under European REACH and CLP regulations due to its carcinogenic classification (Carc. 1B). While not currently listed as an SVHC, it requires extensive safety documentation and risk assessments for any commercial use. Authorization may be required for certain applications. Users must comply with occupational exposure limits and implement risk management measures. The substance falls under various national chemical safety regulations and may require special permits or notifications for import, use, or distribution within the European Union.

4-chloroaniline is available through specialized chemical distributors in Europe, including OYSI, which supplies various chemical products to industrial customers. Due to its carcinogenic classification and regulatory restrictions, purchase is typically limited to qualified industrial users with appropriate safety infrastructure and regulatory compliance. Buyers must demonstrate legitimate industrial use and proper handling capabilities. Contact OYSI or other authorized chemical suppliers for availability, technical specifications, and regulatory documentation required for procurement of this controlled substance.