4-chloroaniline

4-chloroaniline is an aromatic amine compound with the molecular formula C6H6ClN and CAS number 106-47-8. It consists of an aniline molecule with a chlorine atom substituted at the para position (4th position) of the benzene ring. With a molecular weight of 127.57 g/mol, this chemical intermediate is classified as a Category 1B carcinogen and presents multiple hazards including acute toxicity and skin sensitization properties.

4-chloroaniline typically appears as a pale yellow to brown crystalline solid at room temperature with a characteristic amine odor. It has moderate solubility in water and is more soluble in organic solvents like ethanol and ether. The compound is sensitive to light and air, which can cause oxidation and darkening. Its aromatic amine structure makes it reactive towards acids, forming stable salts, and it can undergo typical aniline reactions.

4-chloroaniline serves primarily as an important chemical intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is used in the production of antimalarial drugs, herbicides, and various organic pigments. The compound also functions as a building block for manufacturing rubber chemicals, antioxidants, and other specialty chemicals. Its para-chloro substitution pattern makes it particularly valuable for creating compounds with specific biological activities.

4-chloroaniline requires strict safety measures including wearing appropriate personal protective equipment: chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Avoid skin contact, inhalation, and ingestion due to its carcinogenic and acute toxicity properties. Work in fume hoods when possible, and ensure emergency eyewash and shower facilities are accessible. Regular health monitoring is recommended for workers with potential exposure to this substance.

4-chloroaniline should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources to prevent degradation. Keep containers tightly sealed and away from incompatible materials such as strong oxidizing agents, acids, and bases. Storage areas must be equipped with appropriate containment systems and should be restricted to authorized personnel only. Maintain temperatures below 25°C and ensure adequate spill containment measures.

Immediate decontamination is crucial for any contact with 4-chloroaniline. For skin contact, remove contaminated clothing and wash affected areas thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure.

4-chloroaniline must be disposed of as hazardous waste through licensed waste management companies in accordance with local and European regulations. The substance cannot be disposed of in regular waste streams due to its carcinogenic properties and environmental hazards. Incineration at high temperatures in specialized facilities is typically required. All disposal activities must be documented, and waste codes according to the European Waste Catalogue must be properly assigned.

4-chloroaniline is classified under ADR as Class 6.1 (toxic substances) Packing Group II, requiring specialized hazardous goods transport procedures. Shipments must use appropriate UN-specification packaging, proper labeling with GHS08, GHS06, and GHS09 pictograms, and include safety data sheets. Transport vehicles need placarding, and drivers must hold ADR certification. Emergency response information and contact details must accompany all shipments according to dangerous goods regulations.

4-chloroaniline is subject to extensive European chemical regulations under REACH and CLP classifications, requiring registration and hazard communication. As a Category 1B carcinogen, it faces strict workplace exposure limits and may require authorization for certain uses. The substance is also regulated under various national occupational health and safety legislation. Companies must maintain comprehensive risk assessments and implement appropriate risk management measures for its use.

4-chloroaniline is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across Europe. As a regulated substance requiring proper handling and documentation, purchase is typically restricted to professional users with appropriate facilities and safety measures. OYSI provides technical support, regulatory documentation, and ensures compliance with European chemical regulations for qualified industrial customers requiring this chemical intermediate.