4-methylaniline

C7H9N

CAS106-49-0

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Identification

CAS Number
106-49-0
EC Number
203-403-1
UN Number
3451
Index Number
612-160-00-4
PubChem CID
7813

Physical-chemical properties

Molecular Formula
C7H9N
Molar Mass
107.15 g/mol
IUPAC Name
4-methylaniline

Chemical Identifiers

InChI
InChI=1S/C7H9N/c1-6-2-4-7(8)5-3-6/h2-5H,8H2,1H3
InChI Key
RZXMPPFPUUCRFN-UHFFFAOYSA-N

Overview

4-methylaniline (CAS 106-49-0) is an aromatic amine compound featuring a methyl group substitution on the benzene ring of aniline. 4-methylaniline, also known as para-toluidine, represents an important intermediate in organic synthesis and industrial chemistry. This aromatic amine compound consists of an aniline molecule with a methyl group attached to the para position of the benzene ring, giving it the molecular formula C7H9N and a molecular weight of 107.15 g/mol. The compound appears as a colorless to pale yellow liquid or crystalline solid at room temperature, with characteristic amine odor properties. As a member of the substituted aniline family, 4-methylaniline shares structural similarities with related compounds such as 4-nitroaniline, though it exhibits different reactivity patterns due to the electron-donating nature of the methyl group versus the electron-withdrawing nitro group. This structural difference significantly influences its chemical behavior and industrial applications. The compound exhibits typical aromatic amine properties, including basicity and nucleophilic characteristics that make it valuable in various synthetic pathways. Its classification under ADR Class 6.1 indicates it requires appropriate handling procedures and safety measures during transportation and storage. The methyl substitution enhances its solubility characteristics compared to unsubstituted aniline while maintaining its reactivity toward electrophilic aromatic substitution reactions. Primary industrial applications include its use as an intermediate in dye manufacturing, particularly for azo dyes and pigments, pharmaceutical synthesis, and as a precursor in the production of antioxidants and rubber chemicals. The compound also serves as a building block in agrochemical synthesis and specialty chemical manufacturing. OYSI maintains reliable supply chains for 4-methylaniline to support diverse industrial applications across European markets, ensuring consistent quality and regulatory compliance for technical applications.

Safety & Classification

No Hazard Classification

This substance is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.

Transport (ADR)

UN Number3451
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Namep-Toluidin, fest
Marine PollutantNo

Frequently Asked Questions

What is 4-methylaniline?

4-methylaniline is an aromatic amine compound with the molecular formula C7H9N and CAS number 106-49-0. It consists of an aniline molecule with a methyl group attached to the para position of the benzene ring. This organic compound has a molecular weight of 107.15 g/mol and belongs to the family of substituted anilines, making it an important intermediate in organic synthesis and industrial chemistry applications.

What are the physicochemical properties of 4-methylaniline?

4-methylaniline is a liquid at room temperature with a characteristic amine odor. It appears as a colorless to pale yellow liquid that can darken upon exposure to air and light. The compound is slightly soluble in water but readily soluble in organic solvents such as ethanol, ether, and benzene. It has a boiling point around 200°C and exhibits basic properties due to the amino group present in its structure.

What is 4-methylaniline used for?

4-methylaniline is primarily used as an intermediate in the production of dyes, pigments, and pharmaceuticals. It serves as a key starting material for synthesizing various azo dyes and serves in the manufacture of antioxidants for rubber and plastics. The compound is also utilized in the production of pesticides, photographic chemicals, and as a building block for various organic synthesis reactions in chemical manufacturing processes.

How to handle 4-methylaniline safely?

4-methylaniline should be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. Avoid skin and eye contact as the compound can be absorbed through the skin. Ensure proper grounding when transferring the material to prevent static electricity buildup, and keep away from heat sources and incompatible materials.

How to store 4-methylaniline correctly?

4-methylaniline should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from direct sunlight and heat sources. Keep the substance away from strong oxidizing agents, acids, and incompatible materials. Storage areas should be equipped with appropriate spill containment measures and fire protection systems. Regular inspection of containers for signs of deterioration or leakage is recommended to maintain product integrity and safety.

What to do in case of contact with 4-methylaniline?

Immediate removal from exposure is essential in case of contact with 4-methylaniline. For skin contact, immediately wash the affected area with plenty of soap and water for at least 15 minutes and remove contaminated clothing. In case of eye contact, flush thoroughly with clean water for at least 15 minutes. If inhaled, move the person to fresh air immediately. Seek medical attention promptly for all exposure routes, especially if symptoms develop.

How to dispose of 4-methylaniline appropriately?

4-methylaniline must be disposed of in accordance with local, national, and international waste regulations as it is classified as hazardous waste. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Do not discharge into sewers, waterways, or soil. Small quantities should be collected in appropriate containers and labeled clearly for professional disposal. Consult local environmental authorities for specific disposal requirements and approved disposal facilities in your region.

How to transport 4-methylaniline?

4-methylaniline is classified under ADR Class 6.1 (toxic substances), Packing Group II, requiring specific transport regulations compliance. The substance must be packaged in UN-approved containers with appropriate labeling and documentation. Transport vehicles must carry proper placarding and emergency response information. Only trained personnel should handle transportation, and carriers must comply with dangerous goods transport regulations including route restrictions and emergency procedures.

Is 4-methylaniline subject to particular regulations?

4-methylaniline is subject to various chemical regulations including REACH registration requirements in Europe for commercial use. The substance must comply with CLP regulation for classification, labeling, and packaging. While not listed as an SVHC (Substance of Very High Concern), it may be subject to workplace exposure limits and environmental monitoring requirements. Manufacturers and importers must ensure proper registration and safety data sheet provision according to applicable chemical legislation.

Where to buy 4-methylaniline in Europe?

4-methylaniline is available through OYSI, a European distributor of chemical products, ensuring reliable supply and regulatory compliance across European markets. OYSI provides technical support and proper documentation including safety data sheets and certificates of analysis. As a specialized chemical distributor, OYSI can assist with regulatory requirements and provide guidance on proper handling and storage procedures for industrial and research applications throughout Europe.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.