4-chloro-2-methylaniline
C7H8ClN
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Identification
- CAS Number
- 95-69-2
- EC Number
- 202-441-6
- UN Number
- 2239
- Index Number
- 612-196-00-0
- PubChem CID
- 7251
Physical-chemical properties
- Molecular Formula
- C7H8ClN
- Molar Mass
- 141.60 g/mol
- IUPAC Name
- 4-chloro-2-methylaniline
Chemical Identifiers
- InChI
- InChI=1S/C7H8ClN/c1-5-4-6(8)2-3-7(5)9/h2-4H,9H2,1H3
- InChI Key
- CXNVOWPRHWWCQR-UHFFFAOYSA-N
Overview
4-chloro-2-methylaniline (CAS 95-69-2) is an aromatic amine compound with significant industrial applications and notable hazard classifications requiring careful handling protocols. This chlorinated aniline derivative represents an important intermediate in organic synthesis and chemical manufacturing processes. With its molecular formula C7H8ClN and molecular weight of 141.6 g/mol, 4-chloro-2-methylaniline belongs to the substituted aniline family, sharing structural similarities with other aromatic amines such as N-methylaniline. The compound features both a chlorine substituent at the para position and a methyl group at the ortho position relative to the amino group, conferring specific reactivity patterns that make it valuable for targeted synthetic applications. Safety considerations are paramount when handling this substance, as it carries multiple hazard classifications including Category 1B carcinogenicity, Category 2 mutagenicity, and Category 3 acute toxicity through multiple exposure routes. The compound displays the GHS08 health hazard, GHS06 skull and crossbones, and GHS09 environmental pictograms, with "Danger" as the signal word. Its ADR classification of 6.1 indicates toxic substances requiring specialized transport protocols. Environmental concerns include acute and chronic aquatic toxicity, necessitating proper containment and disposal procedures. Primary industrial applications include its use as an intermediate in dye manufacturing, particularly for azo dyes and pigments, pharmaceutical synthesis where controlled reactivity is essential, and as a building block for agrochemical production. The compound's substitution pattern allows for selective chemical transformations while maintaining stability under typical processing conditions. OYSI maintains strategic inventory of 4-chloro-2-methylaniline to support European chemical manufacturing requirements, ensuring reliable supply chain management for qualified industrial customers.
Safety & Classification
Carc. 1B; Muta. 2; Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; Aquatic Acute 1; Aquatic Chron...
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2239 |
| ADR Class | 6.1 |
| Packing Group | III |
| Tunnel Code | E |
| Proper Shipping Name | 4-Chlor-2-toluidin, flüssig* |
| Marine Pollutant | No |
Frequently Asked Questions
What is 4-chloro-2-methylaniline?
4-chloro-2-methylaniline is an aromatic amine compound with the molecular formula C7H8ClN and CAS number 95-69-2. This organic chemical features a benzene ring substituted with an amino group, a chlorine atom at the 4-position, and a methyl group at the 2-position. With a molecular weight of 141.6 g/mol, it belongs to the class of chloroanilines and is classified as a hazardous substance with carcinogenic and mutagenic properties.
What are the physicochemical properties of 4-chloro-2-methylaniline?
4-chloro-2-methylaniline is typically a solid crystalline substance at room temperature with a characteristic aniline-like odor. As an aromatic amine, it exhibits limited water solubility but dissolves readily in organic solvents such as ethanol, acetone, and benzene. The compound is sensitive to light and air oxidation, which can cause discoloration. Its physicochemical properties make it suitable for various chemical synthesis applications while requiring careful handling due to its hazardous nature.
What is 4-chloro-2-methylaniline used for?
4-chloro-2-methylaniline is primarily used as an intermediate in the synthesis of dyes, pigments, and pharmaceuticals. In the chemical industry, it serves as a building block for producing azo dyes, particularly those used in textile and printing applications. The compound is also utilized in the manufacture of pesticides, herbicides, and other agrochemicals. Additionally, it finds application in the production of specialty chemicals and as a starting material for various organic synthesis reactions.
How to handle 4-chloro-2-methylaniline safely?
4-chloro-2-methylaniline requires strict safety measures due to its carcinogenic and toxic properties. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas or fume hoods. Direct skin and eye contact must be avoided, and inhalation or ingestion prevented. Work surfaces should be regularly cleaned, and contaminated materials properly disposed of. Only trained personnel familiar with handling carcinogenic substances should work with this chemical under controlled conditions.
How to store 4-chloro-2-methylaniline correctly?
4-chloro-2-methylaniline must be stored in a cool, dry, well-ventilated area away from heat sources, direct sunlight, and incompatible materials. The substance should be kept in tightly sealed, properly labeled containers made of compatible materials. Storage areas must be equipped with appropriate containment measures and restricted access due to its carcinogenic nature. Avoid contact with strong oxidizing agents, acids, and bases. Regular inspection of containers for signs of deterioration or leakage is essential for safe storage.
What to do in case of contact with 4-chloro-2-methylaniline?
Immediate action is required upon contact with 4-chloro-2-methylaniline. For skin contact, remove contaminated clothing and rinse affected areas with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and rinse mouth with water. Seek immediate medical attention in all cases and provide the safety data sheet to medical personnel.
How to dispose of 4-chloro-2-methylaniline appropriately?
4-chloro-2-methylaniline must be disposed of as hazardous waste through licensed waste management companies in accordance with local and European regulations. The substance cannot be discharged into sewers, waterways, or regular waste streams due to its carcinogenic and aquatic toxicity properties. Incineration at high temperatures in specialized facilities is typically the preferred disposal method. All disposal activities must be documented, and waste containers properly labeled with hazard information before collection by authorized waste contractors.
How to transport 4-chloro-2-methylaniline?
4-chloro-2-methylaniline is classified under ADR as Class 6.1 (toxic substances), Packing Group III, requiring compliance with dangerous goods transportation regulations. The substance must be packaged in UN-approved containers with appropriate hazard labels and documentation including transport documents and emergency response information. Vehicles must carry proper placarding, and drivers need ADR certification for Class 6.1 materials. Special handling procedures and emergency equipment requirements apply during transportation across European borders.
Is 4-chloro-2-methylaniline subject to specific regulations?
4-chloro-2-methylaniline is subject to strict European regulations under REACH and CLP due to its hazardous properties. As a carcinogenic substance (Category 1B), it requires authorization for certain uses and is subject to restriction measures. The compound must be registered under REACH for commercial use, with safety data sheets mandatory for all suppliers. Workplace exposure limits apply under occupational health regulations, and environmental discharge restrictions are enforced due to its aquatic toxicity classification.
Where to buy 4-chloro-2-methylaniline in Europe?
4-chloro-2-methylaniline is available through OYSI, a specialized European distributor of technical chemicals serving industrial customers across the region. As a regulated substance requiring proper handling expertise, it is only supplied to qualified industrial users with appropriate safety measures and regulatory compliance. OYSI provides comprehensive technical support, proper documentation, and ensures full regulatory compliance for European deliveries. Contact OYSI directly for availability, specifications, and regulatory requirements for your specific application needs.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.