N-phenylaniline

C12H11N

CAS122-39-4
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
122-39-4
EC Number
204-539-4
UN Number
2811
Index Number
612-026-00-5
PubChem CID
11487

Physical-chemical properties

Molecular Formula
C12H11N
Molar Mass
169.22 g/mol
IUPAC Name
N-phenylaniline

Chemical Identifiers

InChI
InChI=1S/C12H11N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10,13H
InChI Key
DMBHHRLKUKUOEG-UHFFFAOYSA-N

Overview

N-phenylaniline (CAS 122-39-4) is an aromatic amine compound with significant industrial applications and notable toxicological properties. N-phenylaniline, also known as diphenylamine, represents a crucial intermediate in various chemical manufacturing processes. This aromatic secondary amine consists of two phenyl rings connected through a nitrogen atom, giving it unique chemical reactivity and stability characteristics. With the molecular formula C12H11N and a molecular weight of 169.22 g/mol, this compound appears as a colorless to pale yellow crystalline solid under standard conditions. The substance exhibits significant safety considerations, classified under multiple hazard categories including acute toxicity (Acute Tox. 3) through oral, dermal, and inhalation routes, and specific target organ toxicity following repeated exposure (STOT RE 2). Its environmental impact profile shows high aquatic toxicity, requiring careful handling and disposal protocols. The GHS classification includes skull and crossbones (GHS06), health hazard (GHS08), and environmental hazard (GHS09) pictograms, emphasizing the need for comprehensive safety measures during handling and storage. Industrial applications of N-phenylaniline span across multiple sectors, primarily serving as an antioxidant in rubber and polymer industries, where it prevents degradation and extends material lifespan. The compound also functions as an important intermediate in dye manufacturing and pharmaceutical synthesis. Unlike simpler aromatic amines such as N-methylaniline, N-phenylaniline offers enhanced thermal stability and oxidation resistance, making it particularly valuable in high-performance applications. The substance requires ADR Class 6.1 transportation classification due to its toxic properties, necessitating specialized logistics and handling expertise. OYSI maintains reliable supply chains for N-phenylaniline, supporting European industrial customers with technical-grade material meeting stringent quality specifications.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2811
ADR Class6.1
Packing GroupIII
Tunnel CodeE
Proper Shipping NameN-Phenylanilin, fest
Marine PollutantNo

Frequently Asked Questions

What is N-phenylaniline?

N-phenylaniline is an organic chemical compound with the molecular formula C12H11N and CAS number 122-39-4. It belongs to the class of aromatic amines and has a molecular weight of 169.22 g/mol. This substance is classified as hazardous with acute toxicity properties and potential for causing specific target organ toxicity after repeated exposure. It also poses environmental hazards to aquatic life.

What are the physicochemical properties of N-phenylaniline?

N-phenylaniline is typically a solid crystalline substance at room temperature with a characteristic aromatic odor. It appears as white to pale yellow crystals or powder that may darken upon exposure to light and air. The compound has limited solubility in water but dissolves readily in organic solvents such as ethanol, benzene, and ether. It has a melting point around 53-54°C and demonstrates stability under normal storage conditions.

What is N-phenylaniline used for?

N-phenylaniline serves primarily as an intermediate in the synthesis of dyes, pharmaceuticals, and rubber chemicals. It is used in the production of antioxidants for rubber and plastics, as well as in the manufacture of various organic compounds. The substance also finds application in research and development activities within chemical laboratories and serves as a building block for more complex aromatic compounds in industrial chemical processes.

How to handle N-phenylaniline safely?

N-phenylaniline requires careful handling due to its acute toxicity classification. Personal protective equipment must include chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation. Given its GHS06 and GHS08 pictograms indicating toxicity and health hazards, minimize exposure and ensure proper training before handling this substance.

How to store N-phenylaniline correctly?

N-phenylaniline should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly sealed to prevent contamination and oxidation. Store separately from incompatible materials such as strong oxidizing agents and acids. The storage area should be equipped with appropriate spill containment measures and clearly labeled with hazard warnings. Maintain inventory rotation to ensure product quality.

What to do in case of contact with N-phenylaniline?

Immediate medical attention may be required for any exposure to N-phenylaniline due to its acute toxicity. In case of skin contact, remove contaminated clothing and wash affected area thoroughly with soap and water. For eye contact, flush immediately with plenty of water for at least 15 minutes. If inhaled, move to fresh air immediately. If ingested, do not induce vomiting and seek medical attention promptly.

How to dispose of N-phenylaniline appropriately?

N-phenylaniline disposal must comply with local and national hazardous waste regulations due to its toxic and environmentally hazardous properties. The substance cannot be disposed of in regular waste streams or sewerage systems. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Small laboratory quantities may require special collection procedures. Maintain disposal records as required by environmental authorities.

How to transport N-phenylaniline?

N-phenylaniline is classified under ADR as Class 6.1 (toxic substances), Packing Group III, indicating moderate toxicity during transport. Packages must be properly labeled with appropriate hazard labels and documentation. Transport vehicles require placarding and drivers need ADR training certification. The substance must be packaged in UN-approved containers and segregated from incompatible materials during transport according to dangerous goods regulations.

Is N-phenylaniline subject to specific regulations?

N-phenylaniline is regulated under the CLP Regulation with its hazard classification and labeling requirements including the 'Danger' signal word and specific pictograms (GHS06, GHS08, GHS09). It falls under REACH registration requirements for chemical substances. The compound is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational health and safety regulations and environmental protection requirements.

Where to buy N-phenylaniline in Europe?

N-phenylaniline is available through OYSI, a European distributor specializing in technical chemical products. As an established chemical distributor, OYSI can provide this substance with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly for availability, technical specifications, and pricing information. Ensure your intended use complies with local regulations before placing orders for this hazardous substance.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.