3,4-dimethylphenol

C8H10O

CAS95-65-8
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
95-65-8
EC Number
202-439-5
UN Number
2261
Index Number
604-006-00-X
PubChem CID
7249

Physical-chemical properties

Molecular Formula
C8H10O
Molar Mass
122.16 g/mol
IUPAC Name
3,4-dimethylphenol

Chemical Identifiers

InChI
InChI=1S/C8H10O/c1-6-3-4-8(9)5-7(6)2/h3-5,9H,1-2H3
InChI Key
YCOXTKKNXUZSKD-UHFFFAOYSA-N

Overview

3,4-dimethylphenol (CAS 95-65-8) is an aromatic organic compound with two methyl substituents positioned on adjacent carbons of the phenol ring structure. This dimethylphenol isomer represents an important intermediate in organic synthesis and industrial chemical manufacturing. The compound features a benzene ring with hydroxyl functionality and two methyl groups at the 3 and 4 positions, giving it distinct chemical properties compared to other phenolic compounds. Its molecular formula C8H10O and molecular weight of 122.16 g/mol place it within the family of substituted phenols commonly used in specialty chemical applications. The substance exhibits significant hazard characteristics, classified under GHS with acute toxicity (Category 3), skin corrosion (Category 1B), and aquatic chronic toxicity (Category 2) properties. The danger signal word and associated pictograms GHS06, GHS05, and GHS09 indicate requirements for careful handling, appropriate personal protective equipment, and controlled storage conditions. Transportation falls under ADR Class 6.1, reflecting its toxic nature. Industrial applications of 3,4-dimethylphenol include its use as a chemical intermediate in pharmaceutical synthesis, production of specialty resins, and manufacturing of antioxidant compounds. The compound serves as a building block for more complex molecules in fine chemical synthesis, where its substitution pattern provides specific reactivity profiles. Unlike simpler aldehydes such as prop-2-enal, this phenolic compound offers aromatic stability combined with controlled reactivity through its hydroxyl group. OYSI maintains availability of 3,4-dimethylphenol for European industrial customers requiring reliable supply of this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H314

Causes severe skin burns and eye damage.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2261
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name3,4-Xylenol, fest
Marine PollutantNo

Frequently Asked Questions

What is 3,4-dimethylphenol?

3,4-dimethylphenol is an organic aromatic compound with the molecular formula C8H10O and CAS number 95-65-8. This phenolic compound features two methyl groups attached to a benzene ring at the 3 and 4 positions relative to the hydroxyl group. With a molecular weight of 122.16 g/mol, it belongs to the family of substituted phenols and exhibits typical phenolic chemical behavior.

What are the physicochemical properties of 3,4-dimethylphenol?

3,4-dimethylphenol is typically a crystalline solid at room temperature with a characteristic phenolic odor. Like most substituted phenols, it exhibits moderate solubility in water and good solubility in organic solvents such as ethanol and acetone. The compound may appear as white to slightly colored crystals and demonstrates typical phenolic properties including acidic behavior and susceptibility to oxidation.

What is 3,4-dimethylphenol used for?

3,4-dimethylphenol serves as an important intermediate in chemical synthesis and pharmaceutical manufacturing. It is commonly used in the production of antioxidants, polymer stabilizers, and various organic compounds. The substance finds applications in the synthesis of specialty chemicals, pharmaceutical intermediates, and as a building block for more complex aromatic compounds in industrial chemistry processes.

How to handle 3,4-dimethylphenol safely?

3,4-dimethylphenol requires careful handling due to its corrosive and toxic properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods. Avoid inhalation, ingestion, and direct skin contact. Emergency eyewash stations and safety showers should be readily accessible during handling operations.

How to store 3,4-dimethylphenol correctly?

3,4-dimethylphenol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers away from incompatible materials such as strong oxidizing agents and bases. Storage areas should be equipped with appropriate spill containment measures and maintained at stable temperatures to prevent degradation. Ensure proper labeling and restrict access to authorized personnel only.

What to do in case of contact with 3,4-dimethylphenol?

3,4-dimethylphenol contact requires immediate action due to its corrosive nature. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water for at least 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Seek medical attention promptly for all exposure incidents.

How to dispose of 3,4-dimethylphenol appropriately?

3,4-dimethylphenol disposal must comply with local and international hazardous waste regulations due to its toxic and environmentally harmful properties. The substance should never be discharged into drains, soil, or waterways. Disposal should be performed through licensed hazardous waste disposal facilities capable of handling toxic organic compounds. Consult local environmental authorities for specific disposal requirements and approved waste management contractors.

How to transport 3,4-dimethylphenol?

3,4-dimethylphenol is classified under ADR Class 6.1 (toxic substances) Packing Group II, indicating significant transport restrictions. Shipments must use UN-approved packaging and proper hazard labeling including GHS06, GHS05, and GHS09 pictograms. Transport vehicles require appropriate documentation, emergency response information, and compliance with dangerous goods regulations. Only certified dangerous goods carriers should handle transportation of this substance.

Is 3,4-dimethylphenol subject to specific regulations?

3,4-dimethylphenol is subject to various European chemical regulations including REACH registration requirements and CLP classification as Acute Tox. 3, Skin Corr. 1B, and Aquatic Chronic 2. While not currently listed as a Substance of Very High Concern (SVHC), it requires proper safety data sheets, hazard communication, and compliance with occupational exposure limits. Users must ensure regulatory compliance for import, use, and distribution.

Where to buy 3,4-dimethylphenol in Europe?

3,4-dimethylphenol is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical distributor, OYSI can provide this substance with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly to discuss your specific requirements, quantities, and delivery options. Professional guidance on handling, storage, and regulatory compliance is typically provided with chemical purchases.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.