3,4-dimethylphenol

C8H10O

CAS95-65-8
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS05 Gefahrensymbol: Ätzend – Ätzwirkung
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
95-65-8
EC Number
202-439-5
UN Number
2261
Index Number
604-006-00-X
PubChem CID
7249

Physical-chemical properties

Molecular Formula
C8H10O
Molar Mass
122.16 g/mol
IUPAC Name
3,4-dimethylphenol

Chemical Identifiers

InChI
InChI=1S/C8H10O/c1-6-3-4-8(9)5-7(6)2/h3-5,9H,1-2H3
InChI Key
YCOXTKKNXUZSKD-UHFFFAOYSA-N

Overview

3,4-dimethylphenol (CAS 95-65-8) is an aromatic organic compound with two methyl substituents on the benzene ring and corrosive properties. This dimethyl-substituted phenolic compound represents an important industrial chemical intermediate widely utilized across various manufacturing sectors. With its molecular formula C8H10O and molecular weight of 122.16 g/mol, 3,4-dimethylphenol exhibits the characteristic properties of substituted phenols while displaying enhanced reactivity due to its specific substitution pattern. The presence of two methyl groups at the 3 and 4 positions relative to the hydroxyl group significantly influences its chemical behavior and industrial applications. The compound presents considerable safety considerations, classified under multiple acute toxicity categories and exhibiting skin corrosive properties (Skin Corr. 1B). Its hazard profile necessitates careful handling protocols, as indicated by the "Danger" signal word and associated GHS pictograms including GHS06 (skull and crossbones), GHS05 (corrosion), and GHS09 (environmental hazard). Transportation falls under ADR Class 6.1, reflecting its toxic nature. The substance also poses environmental concerns with Aquatic Chronic 2 classification, requiring appropriate containment and disposal measures. Industrial applications of 3,4-dimethylphenol primarily include its use as a chemical intermediate in pharmaceutical synthesis, polymer production, and specialty chemical manufacturing. The compound serves as a building block for various downstream products, particularly in the synthesis of antioxidants and stabilizers. Unlike simpler reactive compounds such as prop-2-enal, this substituted phenol offers more selective reactivity patterns suitable for complex synthetic pathways. OYSI provides reliable access to 3,4-dimethylphenol for European industrial customers, ensuring consistent supply chain management for critical manufacturing processes.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Skin Corr. 1B; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H314

Causes severe skin burns and eye damage.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Eye Contact

Harmful

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number2261
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name3,4-Xylenol, fest
Marine PollutantNo

Frequently Asked Questions

What is 3,4-dimethylphenol?

3,4-dimethylphenol is an aromatic organic compound with the molecular formula C8H10O and CAS number 95-65-8. This phenolic compound features two methyl groups attached to the benzene ring at positions 3 and 4 relative to the hydroxyl group. With a molecular weight of 122.16 g/mol, it belongs to the dimethylphenol isomer family and is classified as a hazardous substance requiring careful handling due to its toxic and corrosive properties.

What are the physicochemical properties of 3,4-dimethylphenol?

3,4-dimethylphenol is typically a crystalline solid at room temperature with a characteristic phenolic odor. As a phenolic compound, it exhibits moderate solubility in water and good solubility in organic solvents like alcohols and ethers. The compound has a melting point around 65-68°C and demonstrates typical phenol reactivity, including the ability to form hydrogen bonds due to its hydroxyl group, which influences its physical properties and chemical behavior.

What is 3,4-dimethylphenol used for?

3,4-dimethylphenol is primarily used as an intermediate in chemical synthesis and manufacturing processes. It serves as a building block for producing antioxidants, pharmaceuticals, and specialty chemicals. The compound is also utilized in the synthesis of polymer additives and can be found in certain industrial formulations. Its phenolic structure makes it valuable for applications requiring antioxidant properties or as a precursor for more complex aromatic compounds in fine chemical manufacturing.

How to handle 3,4-dimethylphenol safely?

3,4-dimethylphenol must be handled with extreme caution due to its Acute Tox. 3 and Skin Corr. 1B classifications. Essential protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work should be conducted in well-ventilated areas or under fume extraction systems. Avoid inhalation, ingestion, and skin contact. Emergency eyewash stations and safety showers should be readily accessible, and personnel should be trained in proper handling procedures.

How to store 3,4-dimethylphenol correctly?

3,4-dimethylphenol should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers away from acids, bases, and oxidizing agents to prevent dangerous reactions. Storage areas should be equipped with appropriate containment systems and fire protection measures. Regular inspection of containers for damage or leakage is essential. Access should be restricted to trained personnel only, with proper labeling according to GHS requirements.

What to do in case of contact with 3,4-dimethylphenol?

3,4-dimethylphenol contact requires immediate action due to its corrosive properties. For skin contact, immediately remove contaminated clothing and flush the affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse thoroughly with water for at least 15 minutes and seek immediate medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention immediately. Always consult emergency services for serious exposures.

How to dispose of 3,4-dimethylphenol appropriately?

3,4-dimethylphenol disposal must comply with local and national hazardous waste regulations due to its toxic and environmentally hazardous properties. The compound cannot be disposed of in regular waste streams and requires specialized hazardous waste treatment facilities. Incineration at high temperatures in approved facilities is typically the preferred disposal method. Always consult with certified waste disposal companies and ensure proper documentation for waste tracking. Never dispose of this substance down drains or in regular waste containers.

How to transport 3,4-dimethylphenol?

3,4-dimethylphenol is classified under ADR Class 6.1 (Toxic substances) Packing Group II, indicating significant transport restrictions. Shipments require proper UN packaging specifications, hazard labels (GHS06, GHS05, GHS09), and transport documentation. Vehicles must comply with ADR regulations for toxic substances, including appropriate placarding and driver certification. Emergency response information must accompany shipments. Professional logistics providers experienced in hazardous materials transport should handle all shipments to ensure regulatory compliance.

Is 3,4-dimethylphenol subject to specific regulations?

3,4-dimethylphenol is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification obligations. The compound is not currently listed as a SVHC (Substance of Very High Concern), but its Acute Tox. 3 and Skin Corr. 1B classifications impose strict labeling, safety data sheet, and handling requirements. Industrial users must comply with occupational exposure limits and environmental discharge restrictions. Regular regulatory monitoring is essential as chemical legislation continues to evolve.

Where to buy 3,4-dimethylphenol in Europe?

3,4-dimethylphenol is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI ensures full regulatory compliance, proper packaging, and comprehensive safety documentation for all shipments. Their technical expertise supports customers with safety data sheets, handling guidance, and regulatory compliance assistance. Contact OYSI directly for availability, specifications, and pricing information for your specific application requirements across European markets.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.