2-ethoxyaniline

2-ethoxyaniline is an aromatic amine compound with the molecular formula C8H11NO and CAS number 94-70-2. It consists of an aniline structure with an ethoxy group (-OCH2CH3) attached to the benzene ring at the ortho position. With a molecular weight of 137.18 g/mol, this organic compound is classified as a toxic substance requiring careful handling due to its acute toxicity and potential for causing specific target organ toxicity after repeated exposure.

2-ethoxyaniline is typically a liquid or solid aromatic compound at room temperature, appearing as a colorless to pale yellow substance. As an aromatic amine, it exhibits characteristic amine odor and has limited solubility in water but good solubility in organic solvents like ethanol and ether. The compound's ethoxy substituent influences its physical properties, making it less polar than unsubstituted aniline while maintaining the basic chemical behavior typical of aromatic amines.

2-ethoxyaniline serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of dyes, pigments, and various pharmaceutical compounds where its aromatic amine structure provides essential chemical reactivity. The compound also finds applications in the synthesis of specialty chemicals and as a building block for more complex organic molecules in research and development laboratories within the chemical and pharmaceutical industries.

2-ethoxyaniline requires careful handling due to its Acute Tox. 3 classification and STOT RE 2 hazard rating. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. The compound's danger signal word and GHS06/GHS08 pictograms indicate serious health hazards requiring strict adherence to safety protocols and proper training.

2-ethoxyaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Storage areas must be equipped with appropriate spill containment measures and kept away from incompatible materials such as strong oxidizers and acids. The storage facility should comply with local regulations for toxic substances and include proper labeling with hazard pictograms GHS06 and GHS08 to ensure worker safety and regulatory compliance.

2-ethoxyaniline contact requires immediate first aid measures due to its acute toxicity. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes. If inhaled, move the person to fresh air immediately. For ingestion or severe exposure, seek immediate medical attention and provide the safety data sheet to medical personnel for proper treatment guidance.

2-ethoxyaniline disposal must comply with local and European waste regulations as it is classified as hazardous waste due to its toxicity. The compound should never be poured down drains or disposed of with regular waste. Disposal should be conducted through licensed hazardous waste management companies that can handle toxic organic compounds. Contaminated materials, containers, and personal protective equipment must also be treated as hazardous waste and disposed of according to appropriate regulatory guidelines.

2-ethoxyaniline is classified under ADR Class 6.1 (Toxic substances) Packing Group III for transportation purposes. This classification requires specific packaging, labeling, and documentation for road transport within Europe. Vehicles must display appropriate hazard placards, and drivers need ADR certification for dangerous goods transport. The packaging must meet UN specification standards for toxic substances, and transport documents must include proper shipping names, hazard classes, and emergency response information for safe handling during transit.

2-ethoxyaniline is subject to European REACH regulation requiring registration for manufacture or import above one tonne per year. The compound falls under CLP regulation for classification, labeling, and packaging of hazardous substances, requiring appropriate hazard communication through GHS pictograms and safety data sheets. While not currently listed as an SVHC (Substance of Very High Concern), its toxic properties mean it may be subject to additional restrictions or monitoring under various national and European chemical safety regulations.

2-ethoxyaniline is available through specialized chemical distributors across Europe, with OYSI serving as a reliable European supplier for this compound. As a professional chemical distributor, OYSI can provide proper documentation, safety data sheets, and regulatory compliance support for industrial and research customers. When purchasing, ensure the supplier can provide appropriate packaging, labeling according to CLP regulation, and necessary transport documentation for this Class 6.1 toxic substance to ensure safe and compliant delivery.