2-ethoxyaniline

2-ethoxyaniline is an aromatic amine compound with the molecular formula C8H11NO and CAS number 94-70-2. It consists of an aniline ring substituted with an ethoxy group (-OCH2CH3) at the ortho position. With a molecular weight of 137.18 g/mol, this organic intermediate belongs to the class of substituted anilines and is classified as a hazardous substance with acute toxicity and potential for organ damage upon repeated exposure.

2-ethoxyaniline is typically a liquid or low-melting solid at room temperature with a characteristic amine odor. As an aromatic ether-amine, it exhibits moderate polarity due to both the amino group and ethoxy substituent. The compound is sparingly soluble in water but readily dissolves in organic solvents such as alcohols, ethers, and aromatic hydrocarbons. Its physicochemical properties make it suitable for various organic synthesis applications.

2-ethoxyaniline serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of dyes, pigments, and various pharmaceutical compounds. The compound's reactive amino group and ethoxy substitution make it valuable for synthesizing more complex molecules through reactions such as diazotization, acylation, and coupling reactions. It also finds applications in the manufacture of specialty chemicals and research applications.

Safe handling of 2-ethoxyaniline requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its Acute Tox. 3 classification. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin contact and ingestion, as the compound can cause systemic toxicity and potential organ damage with repeated exposure. Always follow GHS06 and GHS08 pictogram warnings.

2-ethoxyaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers upright and properly labeled with hazard information. Store away from incompatible materials such as strong oxidizing agents, acids, and reactive metals. Ensure storage areas have appropriate spill containment measures and are accessible only to trained personnel familiar with the compound's hazards.

In case of skin contact with 2-ethoxyaniline, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If inhaled, move the person to fresh air immediately. For eye contact, flush with clean water for at least 15 minutes while holding eyelids open. If ingested, do not induce vomiting and seek immediate medical attention. Always consult a physician and provide the safety data sheet.

2-ethoxyaniline must be disposed of as hazardous waste according to local and national regulations due to its toxicity classification. The compound cannot be discharged into sewers or the environment and requires specialized hazardous waste treatment. Contact licensed waste disposal companies for proper collection and treatment. Empty containers should also be handled as hazardous waste. Always consult local environmental authorities for specific disposal requirements in your region.

2-ethoxyaniline is classified under ADR Class 6.1 (toxic substances), Packing Group III for transportation purposes. It requires appropriate UN packaging and labeling with toxic substance markings. Transport vehicles must carry proper documentation including transport documents and emergency response information. Only trained personnel should handle the transportation, and vehicles should be equipped with appropriate spill response materials and emergency contact information.

2-ethoxyaniline is subject to REACH regulation in Europe and must comply with CLP classification requirements, displaying Danger signal word and appropriate GHS pictograms (GHS06, GHS08). The compound is classified as Acute Tox. 3 and STOT RE 2, requiring specific labeling and safety data sheet provisions. While not currently listed as an SVHC substance, it remains subject to standard chemical safety regulations and workplace exposure limits.

2-ethoxyaniline is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides quality-assured chemical products with proper documentation including certificates of analysis and safety data sheets. As a professional chemical supplier, OYSI ensures compliance with European regulations and provides technical support for customers requiring this specialized aromatic amine intermediate for their applications.