3,5-dimethylaniline

C8H11N

CAS108-69-0
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
108-69-0
EC Number
203-607-0
UN Number
1711
Index Number
612-027-00-0
PubChem CID
7949

Physical-chemical properties

Molecular Formula
C8H11N
Molar Mass
121.18 g/mol
IUPAC Name
3,5-dimethylaniline

Chemical Identifiers

InChI
InChI=1S/C8H11N/c1-6-3-7(2)5-8(9)4-6/h3-5H,9H2,1-2H3
InChI Key
MKARNSWMMBGSHX-UHFFFAOYSA-N

Overview

3,5-dimethylaniline (CAS 108-69-0) is an aromatic amine compound featuring two methyl substituents at the 3 and 5 positions of the aniline ring structure. This organic chemical intermediate serves as a crucial building block in various industrial synthesis processes, particularly in the production of dyes, pharmaceuticals, and specialty chemicals. The compound belongs to the substituted aniline family, characterized by its enhanced stability and modified reactivity compared to unsubstituted aniline due to the electron-donating methyl groups. These structural modifications influence both its chemical behavior and biological activity profile. From a safety perspective, 3,5-dimethylaniline requires careful handling protocols due to its acute toxicity classification (Acute Tox. 3) across multiple exposure routes and its potential for specific target organ toxicity with repeated exposure (STOT RE 2). The substance also presents aquatic chronic toxicity concerns, necessitating appropriate environmental protection measures during storage and use. Transportation falls under ADR Class 6.1, reflecting its toxic properties, and proper packaging and documentation are essential for compliance with international shipping regulations. Industrial applications primarily focus on organic synthesis, where 3,5-dimethylaniline functions as an intermediate in pharmaceutical manufacturing and fine chemical production. The compound also finds use in specialized dye synthesis, where its substitution pattern provides specific color properties and fastness characteristics. Related compounds in this chemical family, such as N,N-diethylaniline, share similar applications in industrial chemistry but offer different reactivity profiles and end-use properties. OYSI maintains reliable supply chains for 3,5-dimethylaniline, supporting European manufacturers with technical-grade material and comprehensive safety documentation for various industrial applications.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1711
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name3,5-Xylidin
Marine PollutantNo

Frequently Asked Questions

What is 3,5-dimethylaniline?

3,5-dimethylaniline is an aromatic amine compound with the molecular formula C8H11N and CAS number 108-69-0. This organic chemical belongs to the aniline family, featuring two methyl groups positioned at the 3 and 5 positions on the benzene ring relative to the amino group. With a molecular weight of 121.18 g/mol, it serves as an important intermediate in chemical synthesis and industrial applications.

What are the physicochemical properties of 3,5-dimethylaniline?

3,5-dimethylaniline is typically a liquid or crystalline solid at room temperature with characteristic amine odor. As an aromatic amine, it exhibits moderate solubility in water and good solubility in organic solvents like alcohols and ethers. The compound has a molecular weight of 121.18 g/mol and contains a basic amino group that can participate in various chemical reactions including acylation and alkylation.

What is 3,5-dimethylaniline used for?

3,5-dimethylaniline is primarily used as an intermediate in the synthesis of dyes, pigments, and pharmaceutical compounds. It serves as a building block for manufacturing various aromatic compounds and specialty chemicals in the chemical industry. The compound is also utilized in research and development applications, particularly in organic synthesis where substituted anilines are required for creating more complex molecular structures.

How to handle 3,5-dimethylaniline safely?

3,5-dimethylaniline must be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing due to its Acute Tox. 3 classification. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. The compound requires careful handling as indicated by the GHS06 and GHS08 pictograms, signaling both acute toxicity and health hazards.

How to store 3,5-dimethylaniline correctly?

3,5-dimethylaniline should be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Storage areas must be designed to prevent environmental release due to its Aquatic Chronic 2 classification. The container should be kept away from oxidizing agents and strong acids, and storage facilities should include appropriate containment measures for spill control and environmental protection.

What to do in case of contact with 3,5-dimethylaniline?

Skin contact with 3,5-dimethylaniline requires immediate removal of contaminated clothing and thorough washing with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes and seek medical attention. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention, providing the safety data sheet to medical personnel.

How to dispose of 3,5-dimethylaniline properly?

3,5-dimethylaniline disposal must comply with local, national, and EU waste regulations as it is classified as hazardous waste. The compound cannot be disposed of via regular waste streams due to its toxicity and environmental impact classifications. Disposal should be conducted through licensed hazardous waste treatment facilities that can handle aromatic amines safely, ensuring proper neutralization and preventing environmental contamination.

How to transport 3,5-dimethylaniline?

3,5-dimethylaniline is classified under ADR Class 6.1 (toxic substances) Packing Group II, requiring specific packaging, labeling, and documentation for transport. Shipments must display appropriate hazard labels including GHS06, GHS08, and GHS09 pictograms with 'Danger' signal word. Transport must comply with dangerous goods regulations, using UN-approved packaging and following proper loading, segregation, and emergency response procedures during transit.

Is 3,5-dimethylaniline subject to specific regulations?

3,5-dimethylaniline is regulated under EU CLP Regulation with multiple hazard classifications including Acute Tox. 3 and STOT RE 2. The compound falls under REACH regulation requiring registration and compliance with supply chain communication requirements. While not currently listed as SVHC, its toxic properties subject it to various occupational safety regulations and environmental protection measures across EU member states.

Where to buy 3,5-dimethylaniline in Europe?

3,5-dimethylaniline is available through OYSI, a European distributor specializing in technical chemicals and industrial intermediates. As an established chemical distributor, OYSI can provide this aromatic amine compound with proper documentation, safety data sheets, and regulatory compliance for industrial customers across Europe. Contact OYSI directly for availability, technical specifications, and delivery options for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.