2-bromo-5-hydroxy-4-methoxybenzaldehyde

2-bromo-5-hydroxy-4-methoxybenzaldehyde is an aromatic aldehyde compound with the molecular formula C8H7BrO3 and CAS number 2973-59-3. This brominated benzaldehyde derivative features hydroxyl and methoxy substituents on the benzene ring, giving it unique chemical properties. With a molecular weight of 231.04 g/mol, it belongs to the family of substituted benzaldehydes commonly used in organic synthesis and pharmaceutical intermediates.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is typically a solid compound at room temperature, appearing as crystals or powder with colors ranging from white to light yellow or beige. The presence of the aldehyde group gives it a characteristic aromatic odor. Its solubility varies depending on the solvent, being generally soluble in organic solvents like ethanol and acetone, while showing limited solubility in water due to its aromatic structure.

2-bromo-5-hydroxy-4-methoxybenzaldehyde serves primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of more complex aromatic compounds, pharmaceutical active ingredients, and specialty chemicals. The compound's reactive aldehyde group and substituted benzene ring make it valuable for condensation reactions, coupling reactions, and as a building block in medicinal chemistry research and development.

2-bromo-5-hydroxy-4-methoxybenzaldehyde requires careful handling due to its skin sensitization properties (Skin Sens. 1). Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent direct skin and eye contact, and ensure immediate access to eyewash stations and safety showers. Follow proper hygiene practices and wash hands thoroughly after handling.

2-bromo-5-hydroxy-4-methoxybenzaldehyde should be stored in tightly sealed containers in a cool, dry place away from direct sunlight and heat sources. Keep the substance in its original packaging and ensure proper labeling with hazard information. Store away from incompatible materials such as strong oxidizing agents and bases. Maintain storage temperatures according to supplier specifications and ensure adequate ventilation in storage areas to prevent vapor accumulation.

In case of skin contact with 2-bromo-5-hydroxy-4-methoxybenzaldehyde, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, rinse immediately with clean water for at least 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Seek medical attention if irritation persists or if sensitization symptoms develop. Always consult the safety data sheet for complete emergency procedures.

2-bromo-5-hydroxy-4-methoxybenzaldehyde must be disposed of according to local, national, and international waste regulations as a hazardous chemical waste. Do not discharge into drains, waterways, or the environment due to its aquatic chronic toxicity classification. Contact licensed hazardous waste disposal companies for proper collection and treatment. Small quantities should be handled through appropriate chemical waste programs, while larger amounts require specialized disposal following regulatory guidelines.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transportation. This classification requires appropriate packaging, labeling, and documentation according to dangerous goods regulations. Use UN-approved packaging and ensure proper hazard labels are affixed. Transport vehicles must carry appropriate emergency equipment and documentation. Drivers require ADR training certification, and shipments must comply with routing restrictions and quantity limitations.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is subject to REACH regulation in Europe and must comply with CLP classification and labeling requirements. It carries GHS07 and GHS09 pictograms with 'Warning' signal word due to skin sensitization and aquatic chronic toxicity properties. The substance is not currently listed as SVHC (Substance of Very High Concern). Users must ensure proper risk assessment, safety data sheet distribution, and compliance with occupational exposure limits where applicable.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with complete regulatory documentation, safety data sheets, and certificates of analysis to ensure compliance with European regulations. As an established chemical distributor, OYSI offers reliable supply chains and technical support for customers across various industries requiring this specialized aromatic aldehyde compound.