2-bromo-5-hydroxy-4-methoxybenzaldehyde

2-bromo-5-hydroxy-4-methoxybenzaldehyde is an organic chemical compound with the molecular formula C8H7BrO3 and CAS number 2973-59-3. This aromatic aldehyde features a benzene ring substituted with bromine, hydroxyl, methoxy, and aldehyde functional groups. With a molecular weight of 231.04 g/mol, it belongs to the class of halogenated phenolic aldehydes and is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is a solid compound at room temperature with a molecular weight of 231.04 g/mol. As an aromatic aldehyde containing phenolic and methoxy groups, it typically exhibits limited water solubility but good solubility in organic solvents such as ethanol, methanol, and acetone. The presence of the aldehyde group gives it characteristic odor properties, while the bromine substitution affects its reactivity and physical characteristics.

2-bromo-5-hydroxy-4-methoxybenzaldehyde serves primarily as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of more complex organic molecules, particularly in the synthesis of pharmaceutical compounds, agrochemicals, and specialty chemicals. Its unique substitution pattern makes it valuable for creating specific molecular frameworks in medicinal chemistry and fine chemical production, where the bromine atom can undergo various coupling reactions.

2-bromo-5-hydroxy-4-methoxybenzaldehyde requires careful handling due to its skin sensitization properties (Skin Sens. 1). Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Work in well-ventilated areas or under fume hoods to avoid inhalation. Prevent skin and eye contact, and wash hands thoroughly after handling. Follow good laboratory practices and ensure emergency eyewash and shower facilities are readily accessible.

2-bromo-5-hydroxy-4-methoxybenzaldehyde should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and direct sunlight. Keep containers away from incompatible materials such as strong oxidizing agents and bases. Store in original containers with proper labeling, and maintain temperatures according to supplier specifications. Ensure storage areas have appropriate spill containment measures and restricted access to authorized personnel only.

Skin contact with 2-bromo-5-hydroxy-4-methoxybenzaldehyde requires immediate removal of contaminated clothing and thorough washing of affected skin with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Remove contaminated clothing and wash before reuse. Seek medical attention if irritation persists or if sensitization symptoms develop. Do not induce vomiting if ingested.

2-bromo-5-hydroxy-4-methoxybenzaldehyde must be disposed of according to local, national, and international waste regulations as it poses environmental hazards (Aquatic Chronic 2). Contact licensed waste disposal companies for proper treatment and disposal. Do not discharge to sewers, waterways, or soil. Small laboratory quantities may require specialized incineration at high temperatures with appropriate emission controls. Always consult safety data sheets and regulatory authorities for specific disposal requirements in your jurisdiction.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is classified as ADR Class 9 (Miscellaneous dangerous substances), Packing Group III for transport purposes. It must be packaged in appropriate containers meeting UN specification requirements and properly labeled with hazard markings. Transport vehicles must carry appropriate documentation including transport documents and emergency response information. Drivers should be trained in handling hazardous materials, and transport must comply with ADR/RID regulations for international shipments.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is regulated under various European and international frameworks including REACH registration requirements and CLP classification as a skin sensitizer and aquatic hazard. It carries Warning signal word with GHS07 and GHS09 pictograms. The substance is not currently listed as SVHC (Substance of Very High Concern). Users must comply with occupational exposure limits, environmental discharge restrictions, and proper hazard communication requirements including safety data sheet provision.

2-bromo-5-hydroxy-4-methoxybenzaldehyde is available through OYSI, a specialized European distributor of chemical products. OYSI provides high-quality chemicals with proper documentation including certificates of analysis and safety data sheets compliant with European regulations. As a European distributor, OYSI ensures reliable supply chains, regulatory compliance, and technical support for customers across various industries requiring this specialized chemical intermediate for their manufacturing and research applications.