2-phenylsulfanylaniline

C12H11NS

CAS1134-94-7
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
1134-94-7
EC Number
413-030-8
UN Number
3077
Index Number
612-181-00-9
PubChem CID
365393

Physical-chemical properties

Molecular Formula
C12H11NS
Molar Mass
201.29 g/mol
IUPAC Name
2-phenylsulfanylaniline

Chemical Identifiers

InChI
InChI=1S/C12H11NS/c13-11-8-4-5-9-12(11)14-10-6-2-1-3-7-10/h1-9H,13H2
InChI Key
DGBISJKLNVVJGD-UHFFFAOYSA-N

Overview

2-phenylsulfanylaniline (CAS 1134-94-7) is an aromatic organosulfur compound with amine functionality and phenylthio substitution patterns. This specialized chemical intermediate represents an important class of sulfur-containing aromatic amines widely utilized in synthetic organic chemistry and industrial applications. With its molecular formula C12H11NS and molecular weight of 201.29 g/mol, 2-phenylsulfanylaniline features a distinctive structure combining an aniline moiety with a phenylsulfanyl substituent, providing unique reactivity profiles for various chemical transformations. The compound's dual aromatic ring system connected through a sulfur bridge offers versatile synthetic possibilities, making it particularly valuable in pharmaceutical intermediate synthesis and specialty chemical manufacturing. From a safety perspective, 2-phenylsulfanylaniline requires careful handling protocols due to its classification as a skin sensitizer (Skin Sens. 1) and aquatic chronic toxicity concerns (Aquatic Chronic 2). The compound carries GHS07 and GHS09 pictograms with a "Warning" signal word, indicating moderate hazard levels requiring appropriate personal protective equipment and environmental precautions. Its ADR Class 9 classification facilitates regulated transportation for commercial applications. Industrial applications primarily focus on pharmaceutical intermediate synthesis, where the compound serves as a building block for more complex therapeutic molecules. Additionally, it finds use in specialty dye manufacturing and advanced materials research. Unlike simpler compounds such as ethyl 6,8-dichlorooctanoate, 2-phenylsulfanylaniline's aromatic sulfur-nitrogen framework enables sophisticated molecular modifications essential for high-value chemical synthesis. OYSI maintains reliable European distribution networks for 2-phenylsulfanylaniline, ensuring consistent supply chains for industrial customers requiring this specialized organosulfur intermediate.

Safety & Classification

Warning
Classification:

Skin Sens. 1; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H317

May cause an allergic skin reaction.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name2-Phenylthioanilin
Marine PollutantNo

Frequently Asked Questions

What is 2-phenylsulfanylaniline?

2-phenylsulfanylaniline is an organic chemical compound with the molecular formula C12H11NS and CAS number 1134-94-7. This aromatic amine features a phenyl group connected to an aniline moiety through a sulfur bridge. With a molecular weight of 201.29 g/mol, it belongs to the class of organosulfur compounds and is primarily used as an intermediate in chemical synthesis and pharmaceutical applications.

What are the physicochemical properties of 2-phenylsulfanylaniline?

2-phenylsulfanylaniline is a solid organic compound at room temperature with a molecular weight of 201.29 g/mol. As an aromatic amine containing sulfur, it typically appears as a crystalline powder with characteristic properties of substituted anilines. The compound contains both nitrogen and sulfur heteroatoms, which influence its solubility behavior and chemical reactivity in various solvents and reaction conditions.

What is 2-phenylsulfanylaniline used for?

2-phenylsulfanylaniline serves primarily as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. Its unique structure, combining aniline and thioether functionalities, makes it valuable for producing specialized compounds in drug development, dye synthesis, and materials science. The compound is particularly useful in research applications where both aromatic amine and sulfur-containing moieties are required for specific chemical transformations.

How to handle 2-phenylsulfanylaniline safely?

2-phenylsulfanylaniline must be handled with appropriate personal protective equipment due to its skin sensitization properties (Skin Sens. 1). Wear protective gloves, safety goggles, and suitable clothing to prevent skin contact. Ensure adequate ventilation in the work area and avoid generating dust or aerosols. Handle only in well-ventilated areas or under fume hoods to minimize inhalation risks and prevent skin sensitization reactions.

How to store 2-phenylsulfanylaniline correctly?

2-phenylsulfanylaniline should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep containers properly labeled and protect from moisture and direct sunlight. Store separately from strong oxidizers and acids to prevent unwanted reactions. Maintain storage temperatures according to supplier specifications and ensure proper inventory rotation to maintain product quality.

What to do in case of contact with 2-phenylsulfanylaniline?

In case of skin contact with 2-phenylsulfanylaniline, immediately remove contaminated clothing and wash the affected area thoroughly with soap and plenty of water for at least 15 minutes. If eye contact occurs, flush immediately with clean water for 15 minutes while holding eyelids open. Seek medical attention if irritation develops or persists, especially given the compound's skin sensitization potential. Remove to fresh air if inhaled.

How to dispose of 2-phenylsulfanylaniline appropriately?

2-phenylsulfanylaniline must be disposed of through licensed hazardous waste disposal facilities in accordance with local and European waste regulations. Do not discharge into sewers or waterways due to its aquatic chronic toxicity (Aquatic Chronic 2). Collect waste in appropriate containers, properly label them, and arrange collection through certified waste management companies. Follow all applicable environmental regulations for hazardous chemical waste disposal.

How to transport 2-phenylsulfanylaniline?

2-phenylsulfanylaniline is classified as ADR Class 9 (Miscellaneous Dangerous Goods), Packing Group III for transportation purposes. It must be packaged in approved containers and properly labeled according to ADR regulations. Transport documentation must include the correct shipping name, UN number, and hazard class. Ensure vehicles are properly placarded and drivers hold appropriate dangerous goods certifications for Class 9 materials.

Is 2-phenylsulfanylaniline subject to specific regulations?

2-phenylsulfanylaniline is subject to European chemical regulations including REACH and CLP classification requirements. It is classified as Skin Sens. 1 and Aquatic Chronic 2, requiring appropriate labeling with GHS07 and GHS09 pictograms and 'Warning' signal word. The compound is not currently listed as an SVHC (Substance of Very High Concern), but users must comply with standard chemical safety and environmental protection requirements.

Where to buy 2-phenylsulfanylaniline in Europe?

2-phenylsulfanylaniline is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation, safety data sheets, and regulatory compliance support. As an established supplier network across Europe, OYSI ensures reliable supply chains and technical support for industrial and research customers requiring this specialized aromatic amine compound.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.