2,4-dihydroxy-N-(2-methoxyphenyl)benzamide

C14H13NO4

CAS129205-19-2
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
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Identification

CAS Number
129205-19-2
EC Number
419-090-1
UN Number
3077
Index Number
616-121-00-2
PubChem CID
21226360

Physical-chemical properties

Molecular Formula
C14H13NO4
Molar Mass
259.26 g/mol
IUPAC Name
2,4-dihydroxy-N-(2-methoxyphenyl)benzamide

Chemical Identifiers

InChI
InChI=1S/C14H13NO4/c1-19-13-5-3-2-4-11(13)15-14(18)10-7-6-9(16)8-12(10)17/h2-8,16-17H,1H3,(H,15,18)
InChI Key
UITHTODMDGCMNZ-UHFFFAOYSA-N

Overview

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide (CAS 129205-19-2) is an aromatic benzamide derivative with dual hydroxyl functionality and methoxyphenyl substitution. This specialized benzamide compound represents a significant chemical intermediate in pharmaceutical and industrial applications, characterized by its unique structural features including two hydroxyl groups positioned at the 2,4-positions of the benzene ring and a methoxyphenyl substituent on the amide nitrogen. With a molecular formula of C14H13NO4 and molecular weight of 259.26 g/mol, this compound exhibits distinctive chemical properties that make it valuable for various synthetic pathways and industrial processes. The compound presents specific safety considerations, classified as Skin Sens. 1 and Aquatic Chronic 2 under CLP regulation, requiring appropriate handling protocols with GHS07 and GHS09 pictograms indicating warning-level hazards. The ADR Class 9 classification designates it as a miscellaneous dangerous substance for transport purposes, necessitating proper packaging and documentation during shipment. In terms of chemical properties, the dual hydroxyl functionality provides enhanced reactivity for derivatization reactions, while the methoxy group offers electron-donating characteristics that influence the compound's overall reactivity profile. This structural combination distinguishes it from simpler aromatic compounds like 2-phenylsulfanylaniline, which lacks the hydroxyl and methoxy functionalities. Primary industrial applications include pharmaceutical intermediate synthesis, specialty chemical manufacturing, and research applications where specific aromatic substitution patterns are required. The compound serves particularly well in medicinal chemistry programs and advanced material development projects. OYSI maintains reliable supply chains for 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide, ensuring consistent availability for European industrial customers requiring this specialized benzamide derivative.

Safety & Classification

Warning
Classification:

Skin Sens. 1; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H317

May cause an allergic skin reaction.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Skin Contact

Irritant

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3077
ADR Class9
Packing GroupIII
Tunnel Code-
Proper Shipping Name2,4-Dihydroxy-N-(2-methoxyphenyl)benzamid
Marine PollutantNo

Frequently Asked Questions

What is 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide is an organic chemical compound with the molecular formula C14H13NO4 and CAS number 129205-19-2. This benzamide derivative features two hydroxyl groups on the benzene ring and a methoxyphenyl substituent on the nitrogen atom. With a molecular weight of 259.26 g/mol, it is classified as a skin sensitizer and poses chronic aquatic toxicity risks, requiring careful handling in industrial applications.

What are the physicochemical properties of 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide is a solid organic compound at room temperature with a molecular weight of 259.26 g/mol. The presence of hydroxyl and methoxy functional groups influences its solubility characteristics and intermolecular interactions. As a benzamide derivative, it likely exhibits moderate polarity due to the combination of aromatic rings, hydroxyl groups, and the amide functionality, affecting its dissolution behavior in various solvents.

What is 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide used for?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide serves as a specialized chemical intermediate in pharmaceutical and fine chemical synthesis. Its unique structural features, including the dihydroxy substitution pattern and methoxyphenyl group, make it valuable for developing bioactive compounds and advanced materials. The compound finds applications in research laboratories and specialized manufacturing processes where precise molecular modifications are required for creating targeted chemical products.

How to handle 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide safely?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide requires careful handling due to its skin sensitization properties (Skin Sens. 1 classification). Essential protective equipment includes chemical-resistant gloves, safety goggles, and protective clothing to prevent skin contact. Work in well-ventilated areas or under fume hoods, avoid generating dust, and wash hands thoroughly after handling. The Warning signal word indicates moderate hazard level requiring standard laboratory safety protocols.

How to store 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide correctly?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide should be stored in a cool, dry place away from direct sunlight and heat sources. Keep containers tightly sealed to prevent moisture absorption and contamination. Store separately from incompatible materials and ensure proper labeling with hazard information. Given its skin sensitizing properties, maintain secure storage in designated chemical storage areas with appropriate ventilation and access controls to prevent accidental exposure.

What to do in case of contact with 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide?

Skin contact with 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide requires immediate removal of contaminated clothing and thorough washing with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15-20 minutes and remove contact lenses if present. If inhaled, move to fresh air immediately. Seek medical attention if irritation persists or allergic reactions develop, as this compound is classified as a skin sensitizer.

How to dispose of 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide properly?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide must be disposed of as hazardous chemical waste through licensed waste management companies. Due to its Aquatic Chronic 2 classification, prevent environmental release and follow local environmental regulations. Container disposal requires complete emptying and treatment as contaminated packaging. Consult safety data sheets and local authorities for specific disposal requirements, as improper disposal can harm aquatic ecosystems and violate environmental protection laws.

How to transport 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide is classified as ADR Class 9 (Miscellaneous dangerous goods), Packing Group III, indicating moderate transport hazard. Packages must comply with UN packaging requirements for Class 9 substances and display appropriate hazard labels including GHS07 and GHS09 pictograms. Use approved packaging materials and ensure proper documentation accompanies shipments. Transport vehicles should carry appropriate emergency equipment and drivers must hold valid dangerous goods certifications.

Is 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide subject to specific regulations?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide falls under European REACH regulation requiring registration for quantities above specified thresholds. CLP regulation mandates proper classification and labeling as Skin Sens. 1 and Aquatic Chronic 2 with Warning signal word and GHS07/GHS09 pictograms. The compound is not currently listed as an SVHC substance. Users must comply with occupational safety regulations and environmental protection requirements when handling this chemical.

Where to buy 2,4-dihydroxy-N-(2-methoxyphenyl)benzamide in Europe?

2,4-dihydroxy-N-(2-methoxyphenyl)benzamide is available through OYSI, a specialized European distributor of technical chemicals and fine chemical intermediates. OYSI provides reliable supply chain management and regulatory compliance support for this specialized compound. Contact OYSI directly for availability, technical specifications, and regulatory documentation. As a professional chemical distributor, OYSI ensures proper handling, packaging, and documentation compliance with European chemical regulations for safe delivery.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.