1-(dimethoxymethyl)-2-nitrobenzene

1-(dimethoxymethyl)-2-nitrobenzene is an organic chemical compound with the molecular formula C9H11NO4 and CAS number 20627-73-0. This aromatic nitro compound features a benzene ring substituted with a nitro group and a dimethoxymethyl group in ortho positions. With a molecular weight of 197.19 g/mol, it belongs to the class of nitrobenzene derivatives and is classified as a skin sensitizer with potential environmental impact on aquatic life.

1-(dimethoxymethyl)-2-nitrobenzene is a solid organic compound at room temperature with distinctive chemical properties. As a nitrobenzene derivative, it typically exhibits characteristic aromatic properties and may have a yellowish appearance. The compound contains both hydrophobic aromatic and hydrophilic methoxy functional groups, influencing its solubility behavior. Its molecular structure with electron-withdrawing nitro and electron-donating methoxy groups creates specific reactivity patterns typical of substituted aromatic compounds.

1-(dimethoxymethyl)-2-nitrobenzene serves as an important chemical intermediate in organic synthesis and pharmaceutical manufacturing. This compound is primarily used in the production of fine chemicals, active pharmaceutical ingredients (APIs), and advanced organic materials. Its unique substitution pattern makes it valuable for developing complex molecular structures in medicinal chemistry and specialty chemical applications. The compound finds applications in research laboratories and industrial synthesis where specific aromatic building blocks are required.

1-(dimethoxymethyl)-2-nitrobenzene requires careful handling due to its skin sensitization properties (Skin Sens. 1). Personnel must wear appropriate personal protective equipment including nitrile gloves, safety goggles, and protective clothing to prevent skin and eye contact. Work should be conducted in well-ventilated areas or under fume hoods. Avoid generating dust or vapors, and ensure proper hygiene measures including thorough handwashing after handling. Emergency eyewash stations and safety showers should be readily accessible.

1-(dimethoxymethyl)-2-nitrobenzene should be stored in a cool, dry, well-ventilated area away from direct sunlight and heat sources. Keep containers tightly sealed to prevent moisture absorption and contamination. Store separately from strong oxidizing agents, reducing agents, and incompatible materials. Maintain storage temperatures according to supplier specifications and ensure proper labeling with hazard information. Storage areas should be equipped with appropriate spill containment measures and emergency response equipment.

Immediate action is required if contact with 1-(dimethoxymethyl)-2-nitrobenzene occurs due to its skin sensitization properties. For skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, rinse immediately with clean water for 15 minutes while holding eyelids open. If inhaled, move to fresh air immediately. Seek medical attention if irritation persists or develops, and provide the safety data sheet to medical personnel.

1-(dimethoxymethyl)-2-nitrobenzene must be disposed of according to local, national, and international waste regulations due to its classification as Aquatic Chronic 2. Do not discharge into drains, waterways, or soil. Collect waste in appropriate containers and label clearly for hazardous waste disposal. Contact licensed waste management companies specialized in chemical waste treatment. Incineration at authorized facilities with appropriate emission controls is typically the preferred disposal method. Ensure compliance with REACH and local environmental protection requirements.

1-(dimethoxymethyl)-2-nitrobenzene is classified as ADR Class 9 (Miscellaneous Dangerous Goods), Packing Group III for transport purposes. This classification requires specific packaging, labeling, and documentation according to international dangerous goods regulations. Packages must display appropriate hazard labels and proper shipping names. Transport vehicles must carry emergency response information and appropriate fire extinguishing equipment. Drivers require ADR certification for Class 9 materials, and transport must follow designated routes with proper emergency preparedness measures.

1-(dimethoxymethyl)-2-nitrobenzene is subject to multiple regulatory frameworks including REACH registration requirements in the European Union and CLP classification regulations. The compound is classified under GHS with pictograms GHS07 and GHS09, requiring appropriate labeling and safety data sheets. While not currently listed as an SVHC (Substance of Very High Concern), its skin sensitization and aquatic toxicity properties require compliance with occupational health regulations and environmental protection measures across different jurisdictions.

1-(dimethoxymethyl)-2-nitrobenzene is available through OYSI, a specialized European distributor of technical chemicals and pharmaceutical intermediates. OYSI provides this compound with full regulatory compliance, including proper REACH registration, safety data sheets, and quality documentation. As an established chemical distributor, OYSI ensures reliable supply chains and technical support for industrial and research applications. Contact OYSI directly for availability, specifications, packaging options, and regulatory documentation specific to your requirements and location within Europe.