1H-pyrrole

1H-pyrrole is a five-membered aromatic heterocycle containing one nitrogen atom and four carbon atoms. With the molecular formula C4H5N and CAS number 109-97-7, it has a molecular weight of 67.09 g/mol. This organic compound serves as a fundamental building block in organic chemistry and appears as a colorless liquid with a characteristic odor. Its aromatic nature gives it special stability and reactivity patterns typical of heterocyclic compounds.

1H-pyrrole is a colorless to pale yellow liquid at room temperature with a distinctive, somewhat unpleasant odor reminiscent of chloroform. It has a boiling point of approximately 130°C and is moderately soluble in water due to its polar nitrogen atom. The compound is highly soluble in most organic solvents including alcohols, ethers, and hydrocarbons. It readily polymerizes upon exposure to air and light, often developing a dark coloration over time.

1H-pyrrole serves as a crucial intermediate in pharmaceutical synthesis, particularly for manufacturing various drug compounds and active pharmaceutical ingredients. It is extensively used in the production of conducting polymers like polypyrrole for electronic applications. The compound also finds application in agrochemical synthesis, dye manufacturing, and as a building block for specialized organic compounds. Additionally, it serves as a precursor for porphyrin synthesis and other complex heterocyclic structures in research applications.

1H-pyrrole should be handled in well-ventilated areas or under fume hoods to prevent inhalation of vapors. Wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and protective clothing. Avoid skin and eye contact, as the compound can cause irritation. Keep away from heat sources, sparks, and open flames due to its flammable nature. Always use appropriate grounding procedures when transferring the material to prevent static electricity buildup.

1H-pyrrole must be stored in a cool, dry place away from direct sunlight and heat sources to prevent polymerization and decomposition. Keep containers tightly sealed in a well-ventilated storage area, preferably under inert atmosphere or with stabilizers to prevent oxidation. Store separately from strong acids, bases, and oxidizing agents. Use amber glass bottles or other UV-protective containers to minimize light exposure, and maintain storage temperatures below 25°C for optimal stability.

In case of skin contact with 1H-pyrrole, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for at least 15 minutes and seek medical attention. If inhaled, move the person to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist or worsen.

1H-pyrrole must be disposed of as hazardous chemical waste in accordance with local, national, and EU regulations. Do not pour down drains or dispose of in regular waste streams. Contact licensed waste disposal companies for proper collection and treatment. Small quantities can often be neutralized or incinerated at appropriate high-temperature facilities. Always consult your local environmental authorities for specific disposal requirements and maintain proper waste documentation for regulatory compliance.

1H-pyrrole is classified as ADR Class 3 (flammable liquids), Packing Group III for transport purposes. It must be packaged in appropriate UN-specification containers and properly labeled with hazard diamonds and identification numbers. Transport vehicles must comply with ADR requirements including appropriate placarding and equipment. Drivers must have proper training and carry transport documents. Ensure containers are properly secured and protected from temperature extremes during transit.

1H-pyrrole is regulated under various European chemical regulations including REACH, requiring registration for commercial use above certain tonnages. While not currently listed as a Substance of Very High Concern (SVHC), it must comply with CLP regulation for classification and labeling requirements. Users must maintain safety data sheets and ensure proper risk assessments. Some countries may have additional restrictions on its use or handling, so always verify local regulatory requirements before use.

1H-pyrrole is available through OYSI, a specialized European distributor of technical chemicals serving various industries across the continent. OYSI provides reliable supply chains and technical support for customers requiring this compound for pharmaceutical, polymer, or research applications. As a professional chemical distributor, OYSI ensures proper packaging, documentation, and regulatory compliance for safe delivery throughout Europe. Contact OYSI directly for current availability, specifications, and pricing information.