1H-pyrrole

1H-pyrrole is a five-membered aromatic heterocyclic organic compound with the molecular formula C4H5N and CAS number 109-97-7. It consists of four carbon atoms and one nitrogen atom arranged in a ring structure, with the nitrogen atom containing a hydrogen substituent. This compound has a molecular weight of 67.09 g/mol and serves as an important building block in organic synthesis and pharmaceutical chemistry.

1H-pyrrole is a colorless to pale yellow liquid at room temperature with a characteristic sweet, chloroform-like odor. It has a boiling point of approximately 130°C and is moderately soluble in water while being highly soluble in most organic solvents including ethanol, ether, and benzene. The compound is aromatic due to its conjugated π-electron system and exhibits basic properties due to the nitrogen atom in the ring structure.

1H-pyrrole serves as a crucial intermediate in pharmaceutical synthesis, particularly for manufacturing porphyrins, chlorophyll analogs, and various pharmaceutical compounds. It is used in the production of conducting polymers like polypyrrole for electronic applications, as a building block for agrochemicals, and in the synthesis of dyes and pigments. Additionally, it finds applications in research laboratories for organic synthesis and as a precursor for heterocyclic chemistry studies.

1H-pyrrole should be handled with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and lab coats. Work should be conducted in well-ventilated areas or under fume hoods to avoid inhalation of vapors. Avoid contact with skin, eyes, and clothing, and prevent ingestion. Use non-sparking tools and equipment since the compound is classified as flammable. Ensure proper grounding and bonding during transfer operations to prevent static electricity buildup.

1H-pyrrole must be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames due to its flammable nature. Keep containers tightly closed and store in original packaging or compatible containers made of appropriate materials. Avoid exposure to strong oxidizing agents and acids which may cause incompatible reactions. Storage areas should be equipped with appropriate fire suppression systems and maintained at temperatures below 25°C when possible.

1H-pyrrole exposure requires immediate action depending on the contact route. For skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush with clean water for 15 minutes while holding eyelids open. If inhaled, move the person to fresh air and seek medical attention if breathing difficulties occur. For ingestion, do not induce vomiting and seek immediate medical attention.

1H-pyrrole waste must be disposed of according to local, national, and international regulations as hazardous chemical waste. The compound should not be poured down drains or released into the environment. Contact licensed waste disposal contractors who specialize in organic chemical waste treatment. Small quantities may be suitable for incineration at appropriate high-temperature facilities with proper emission controls. Always consult current waste disposal regulations and safety data sheets before disposal.

1H-pyrrole is classified under ADR Class 3 (Flammable Liquids), Packing Group III for transportation purposes. It must be packaged in UN-approved containers and labeled with appropriate hazard markings and documentation. Transport vehicles must comply with ADR regulations including proper placarding, emergency equipment, and driver training requirements. Shipments should be accompanied by appropriate transport documents and emergency response information. Ensure containers are properly secured and protected from damage during transit.

1H-pyrrole is regulated under various chemical legislation frameworks including REACH regulation in Europe, where it must be registered for commercial use above certain tonnage thresholds. The compound is not classified as a Substance of Very High Concern (SVHC) under current regulations. Users must comply with CLP regulation requirements for classification, labeling, and packaging. Additionally, workplace exposure limits and industrial emission standards may apply depending on the specific application and local regulations.

1H-pyrrole is available through OYSI, a leading European distributor of specialty chemicals serving industrial and research customers across Europe. OYSI provides reliable supply chains and technical support for chemical procurement needs. The compound can also be sourced from other specialized chemical distributors and manufacturers who serve the European market. When selecting a supplier, ensure they provide proper documentation, safety data sheets, and comply with European chemical regulations including REACH requirements.