Propane-1-thiol
C3H8S
propane-1-thiol
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Identification
- CAS Number
- 107-03-9
- EC Number
- 203-455-5
- UN Number
- 2402
- PubChem CID
- 7848
Physical-chemical properties
- Molecular Formula
- C3H8S
- Molar Mass
- 76.16 g/mol
- IUPAC Name
- propane-1-thiol
Chemical Identifiers
- InChI
- InChI=1S/C3H8S/c1-2-3-4/h4H,2-3H2,1H3
- InChI Key
- SUVIGLJNEAMWEG-UHFFFAOYSA-N
Overview
Propane-1-thiol (CAS 107-03-9) is an organosulfur compound characterized by its distinctive mercaptan structure and strong odor properties. This linear aliphatic thiol represents one of the most important members of the primary mercaptan family, featuring a sulfhydryl (-SH) functional group attached to a three-carbon propyl chain. With its molecular formula C3H8S and molecular weight of 76.16 g/mol, propane-1-thiol exhibits the characteristic properties of low molecular weight thiols, including high volatility and exceptional odor intensity even at trace concentrations. The compound appears as a colorless liquid with an extremely pungent, skunk-like odor detectable at parts-per-billion levels. This powerful olfactory property makes it invaluable in applications requiring precise odor detection or warning capabilities. Propane-1-thiol demonstrates typical thiol reactivity, readily participating in oxidation reactions to form disulfides and showing strong nucleophilic behavior through its sulfur atom. From a safety perspective, propane-1-thiol is classified under ADR Class 3 as a flammable liquid, requiring appropriate fire prevention measures during handling and storage. While not assigned specific GHS pictograms, proper ventilation and odor containment protocols are essential due to its potent smell and potential respiratory irritation at elevated concentrations. Industrial applications primarily center on its use as an odorant additive for natural gas and propane, where its intense smell provides crucial safety warning properties for gas leak detection. The compound also serves as an intermediate in pharmaceutical synthesis and specialty chemical manufacturing. Unlike structurally different compounds such as 2,2,5-trimethylhex-4-enal, propane-1-thiol's mercaptan functionality provides unique chemical reactivity for specific synthetic pathways. OYSI supplies propane-1-thiol to meet diverse industrial requirements across European markets, supporting applications from gas odorization to specialty chemical synthesis.
Safety & Classification
No Hazard Classification
This substance is not classified as hazardous according to CLP Regulation (EC) No 1272/2008.
Transport (ADR)
| UN Number | 2402 |
| ADR Class | 3 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | 1-Propanthiol |
| Marine Pollutant | No |
Frequently Asked Questions
What is propane-1-thiol?
Propane-1-thiol is an organosulfur compound with the molecular formula C3H8S and CAS number 107-03-9. It belongs to the thiol family, characterized by the presence of a sulfhydryl (-SH) functional group attached to a three-carbon propane chain. With a molecular weight of 76.16 g/mol, this colorless liquid is known for its distinctive strong, unpleasant odor reminiscent of rotten eggs or garlic, making it easily detectable even at very low concentrations.
What are the physicochemical properties of propane-1-thiol?
Propane-1-thiol is a colorless liquid at room temperature with an extremely strong, penetrating odor characteristic of thiols. It has a boiling point of approximately 67-68°C and is slightly soluble in water but readily miscible with most organic solvents including alcohols and ethers. The compound is volatile and has a relatively low flash point, making it flammable. Its sulfur-containing structure gives it reducing properties and the ability to form disulfide bonds under oxidizing conditions.
What is propane-1-thiol used for?
Propane-1-thiol serves multiple industrial applications, primarily as an intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of pesticides, rubber chemicals, and various sulfur-containing compounds. The compound also finds application as a flavoring agent in very small quantities due to its intense odor, and in gas odorization for leak detection purposes. Additionally, it serves as a building block in the synthesis of more complex organosulfur molecules in chemical research and development.
How to handle propane-1-thiol safely?
Propane-1-thiol requires careful handling with appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Work should be conducted in a fume hood to prevent exposure to its strong odor and potential vapors. Avoid contact with skin, eyes, and clothing, and ensure no ignition sources are present due to its flammable nature. Use non-sparking tools and equipment, and have emergency eyewash stations and safety showers readily accessible in the work area.
How to store propane-1-thiol correctly?
Propane-1-thiol should be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames due to its flammable properties. Keep containers tightly sealed to prevent vapor escape and odor issues. Store away from oxidizing agents, strong bases, and metals that could catalyze unwanted reactions. Use appropriate secondary containment and ensure storage areas comply with local fire safety regulations. Maintain storage temperatures below 25°C and protect from direct sunlight to prevent decomposition.
What to do in case of contact with propane-1-thiol?
Propane-1-thiol contact requires immediate action depending on the exposure route. For skin contact, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush with clean water for 15-20 minutes and seek medical attention. In case of inhalation, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician if symptoms persist or worsen.
How to dispose of propane-1-thiol properly?
Propane-1-thiol disposal must comply with local and national hazardous waste regulations as it is classified as flammable waste. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Do not pour down drains, sewers, or onto the ground as it can contaminate water sources and create odor problems. Small quantities may be disposed of through controlled incineration at appropriate high-temperature facilities. Always consult local environmental authorities for specific disposal requirements and approved waste treatment facilities.
How to transport propane-1-thiol?
Propane-1-thiol is classified under ADR Class 3 (flammable liquids) Packing Group II, requiring specific transportation protocols. It must be packaged in UN-approved containers with appropriate labeling and documentation. Vehicles must comply with ADR regulations for flammable substances, including proper placarding and equipment. Drivers require ADR certification for dangerous goods transport. Shipments must include proper shipping papers, emergency response information, and comply with routing restrictions. Ensure adequate ventilation during transport and avoid temperature extremes.
Is propane-1-thiol subject to specific regulations?
Propane-1-thiol is regulated under various European chemical legislations including REACH, where it must be registered for commercial use above certain tonnage thresholds. It falls under CLP regulation for classification and labeling of chemicals, requiring appropriate safety data sheets and hazard communication. The substance is not currently listed as an SVHC (Substance of Very High Concern) under REACH. Transport regulations under ADR apply for shipment, and local environmental regulations may govern its use, storage, and disposal in different EU member states.
Where to buy propane-1-thiol in Europe?
Propane-1-thiol is available through OYSI, a leading European distributor of specialty chemicals serving industrial customers across the continent. OYSI provides high-quality propane-1-thiol with complete regulatory documentation, safety data sheets, and technical support. As an established chemical distributor, OYSI ensures compliance with European regulations and offers reliable supply chain solutions. For pricing, availability, and technical specifications, contact OYSI directly through their customer service channels to discuss your specific requirements and application needs.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.