1-chloro-4-(trichloromethyl)benzene

C7H4Cl4

CAS5216-25-1
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
Danger

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Identification

CAS Number
5216-25-1
EC Number
226-009-1
UN Number
3265
Index Number
602-093-00-9
PubChem CID
21277

Physical-chemical properties

Molecular Formula
C7H4Cl4
Molar Mass
229.90 g/mol
IUPAC Name
1-chloro-4-(trichloromethyl)benzene

Chemical Identifiers

InChI
InChI=1S/C7H4Cl4/c8-6-3-1-5(2-4-6)7(9,10)11/h1-4H
InChI Key
LVZPKYYPPLUECL-UHFFFAOYSA-N

Overview

1-chloro-4-(trichloromethyl)benzene (CAS 5216-25-1) is an organochlorine compound with significant industrial applications and notable safety considerations. This highly chlorinated aromatic compound, with molecular formula C7H4Cl4 and molecular weight 229.9 g/mol, represents an important intermediate in chemical synthesis processes. The substance features a benzene ring substituted with both a chlorine atom and a trichloromethyl group, giving it unique reactivity characteristics that make it valuable in specialized industrial applications. The compound presents significant safety considerations, classified under multiple hazard categories including carcinogenicity (Category 1B), reproductive toxicity (Category 2), and specific target organ toxicity. It requires careful handling protocols due to its corrosive nature, reflected in its ADR Class 8 classification and GHS08/GHS07 pictograms with the signal word "Danger." The substance can cause skin irritation and poses risks to human health through various exposure routes. Industrial applications of 1-chloro-4-(trichloromethyl)benzene primarily include its use as a chemical intermediate in pharmaceutical synthesis, specialty chemical production, and as a building block for more complex organochlorine compounds. Its reactivity profile makes it particularly suitable for nucleophilic substitution reactions and coupling processes in fine chemical manufacturing. While structurally different from compounds like cyclohexanamine, both substances share importance as chemical intermediates in industrial synthesis, though with distinctly different safety profiles and application areas. The high chlorine content of this benzene derivative requires specialized handling equipment and expertise. OYSI provides this technical-grade chemical intermediate to qualified industrial customers across Europe, supporting specialized chemical manufacturing and research applications.

Safety & Classification

Danger
Classification:

Carc. 1B; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; STOT SE 3; STOT RE 1; Skin Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H350

May cause cancer.

H312

Harmful in contact with skin.

H302

Harmful if swallowed.

H335

May cause respiratory irritation.

H372

Causes damage to organs through prolonged or repeated exposure.

H315

Causes skin irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Irritant

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Harmful

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Harmful

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3265
ADR Class8
Packing GroupII
Tunnel CodeE
Proper Shipping Name1-Chlor-4-(trichlormethyl)benzen
Marine PollutantNo

Frequently Asked Questions

What is 1-chloro-4-(trichloromethyl)benzene?

1-chloro-4-(trichloromethyl)benzene is an organochlorine compound with the molecular formula C7H4Cl4 and CAS number 5216-25-1. This chemical substance has a molecular weight of 229.9 g/mol and belongs to the class of chlorinated aromatic compounds. It is classified as a hazardous substance with multiple health risks including carcinogenicity, reproductive toxicity, and organ toxicity, requiring careful handling in industrial applications.

What are the physicochemical properties of 1-chloro-4-(trichloromethyl)benzene?

1-chloro-4-(trichloromethyl)benzene is a chlorinated aromatic compound that typically appears as a solid at room temperature. As a highly chlorinated organic substance, it exhibits low water solubility but good solubility in organic solvents. The compound contains four chlorine atoms attached to a benzene ring structure, giving it distinctive chemical stability and resistance to degradation under normal conditions.

What is 1-chloro-4-(trichloromethyl)benzene used for?

1-chloro-4-(trichloromethyl)benzene is primarily used as an intermediate in organic synthesis and chemical manufacturing processes. It serves as a precursor for the production of other chlorinated compounds and specialty chemicals. Due to its hazardous classification, its use is restricted to professional industrial applications where proper safety measures and regulatory compliance can be ensured.

How to handle 1-chloro-4-(trichloromethyl)benzene safely?

1-chloro-4-(trichloromethyl)benzene requires strict safety protocols including wearing appropriate personal protective equipment such as chemical-resistant gloves, safety goggles, and respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Given its carcinogenic and toxic properties, minimize direct contact and ensure proper training for all personnel handling this substance.

How to store 1-chloro-4-(trichloromethyl)benzene correctly?

1-chloro-4-(trichloromethyl)benzene should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from incompatible materials. Storage areas must be secured and accessible only to trained personnel due to its hazardous classification. Containers should be properly labeled according to GHS requirements, displaying appropriate pictograms GHS08 and GHS07 with danger signal words.

What to do in case of contact with 1-chloro-4-(trichloromethyl)benzene?

Immediate action is required upon contact with 1-chloro-4-(trichloromethyl)benzene due to its toxic properties. For skin contact, remove contaminated clothing and wash thoroughly with soap and water. In case of eye contact, flush immediately with clean water for at least 15 minutes. If inhaled, move to fresh air immediately. Seek medical attention promptly in all cases of exposure and provide safety data sheet information to medical personnel.

How to dispose of 1-chloro-4-(trichloromethyl)benzene properly?

1-chloro-4-(trichloromethyl)benzene must be disposed of as hazardous waste through licensed waste management companies in accordance with local and European regulations. The substance cannot be disposed of through regular waste streams due to its toxic and potentially carcinogenic properties. Disposal methods typically include high-temperature incineration in specialized facilities equipped to handle chlorinated organic compounds safely.

How to transport 1-chloro-4-(trichloromethyl)benzene?

1-chloro-4-(trichloromethyl)benzene is classified under ADR Class 8 (corrosive substances) Packing Group II for transportation purposes. Transport requires appropriate UN-approved packaging, proper labeling with hazard diamonds, and accompanying transport documents. Only authorized carriers trained in hazardous materials transport should handle shipments, ensuring compliance with European ADR regulations for safe road transport.

Is 1-chloro-4-(trichloromethyl)benzene subject to specific regulations?

1-chloro-4-(trichloromethyl)benzene is subject to comprehensive European chemical regulations including REACH registration requirements and CLP classification obligations. Its classification as Carcinogenic 1B and Reproductive Toxicant 2 subjects it to strict regulatory oversight. Users must comply with occupational exposure limits, proper labeling requirements, and safety data sheet provisions. Professional use restrictions may apply due to its hazardous properties.

Where to buy 1-chloro-4-(trichloromethyl)benzene in Europe?

1-chloro-4-(trichloromethyl)benzene is available through OYSI, a specialized European distributor of technical chemicals. As a professional chemical supplier, OYSI ensures regulatory compliance, proper documentation, and safe handling procedures for hazardous substances. Contact OYSI directly for availability, technical specifications, and regulatory support for this controlled chemical substance, ensuring proper authorization for intended industrial applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.