2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride is an organosulfur compound with the molecular formula C7H7ClF3NS and CAS number 4274-38-8. This chemical features a benzene ring substituted with an amino group, a trifluoromethyl group, and a thiol group, presented as a hydrochloride salt. With a molecular weight of 229.65 g/mol, it is classified as a hazardous substance requiring careful handling due to its corrosive and toxic properties.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride is typically a solid compound at room temperature due to its hydrochloride salt form. The presence of the trifluoromethyl group significantly influences its chemical stability and reactivity. As a hydrochloride salt, it generally exhibits good water solubility compared to the free base form. The compound's properties are affected by the electron-withdrawing trifluoromethyl group and the presence of both amino and thiol functional groups.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride is primarily used as an intermediate in pharmaceutical synthesis and fine chemical manufacturing. The compound serves as a building block for developing pharmaceutical compounds, particularly those requiring trifluoromethyl-substituted aromatic systems. It may also be utilized in agrochemical synthesis and specialized organic chemistry research applications where the unique combination of amino, thiol, and trifluoromethyl functionalities is required for specific molecular architectures.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride requires strict safety measures due to its corrosive and toxic nature. Personnel must wear appropriate PPE including chemical-resistant gloves, safety goggles, and protective clothing. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid skin and eye contact completely. Handle with suitable tools to minimize direct contact, and ensure emergency eyewash and shower facilities are readily accessible in the work area.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed to prevent moisture absorption and contamination. Store separately from strong oxidizing agents, bases, and metals due to potential incompatibilities. Use appropriate secondary containment and ensure storage areas are equipped with spill control measures. Maintain proper inventory management and regular inspection of container integrity.

Immediate action is required upon contact with 2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride due to its corrosive properties. For skin contact, remove contaminated clothing and rinse thoroughly with water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes. If inhaled, move to fresh air immediately. Seek immediate medical attention for all exposure routes. Do not induce vomiting if ingested. Provide the safety data sheet to medical personnel.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride must be disposed of as hazardous chemical waste through licensed waste management companies. The substance cannot be discharged to sewers, soil, or waterways due to its toxic and corrosive nature. Collect waste in appropriate containers, properly labeled with contents and hazard information. Follow local environmental regulations and waste classification codes. Incineration at authorized high-temperature facilities is typically the preferred disposal method for organosulfur compounds containing fluorinated groups.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride is classified as ADR Class 8 (corrosive substances), Packing Group II, indicating significant transport restrictions. Packages must comply with UN packaging specifications and bear appropriate hazard labels including GHS pictograms GHS05, GHS07, GHS08, and GHS09. Transport documents must include proper shipping names and emergency response information. Only trained personnel should handle shipments, and vehicles must carry appropriate spill control equipment and emergency contact information.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride is subject to multiple regulatory frameworks including REACH registration requirements in Europe and CLP classification as a hazardous substance. The compound is not currently listed as a Substance of Very High Concern (SVHC). Users must comply with occupational health and safety regulations, environmental discharge limits, and proper hazard communication requirements. Import/export may require additional documentation, and industrial users must implement appropriate risk management measures according to regulatory guidelines.

2-amino-4-(trifluoromethyl)benzenethiol;hydrochloride is available through OYSI, a specialized European distributor of fine chemicals and pharmaceutical intermediates. OYSI provides high-quality chemical products with proper documentation including certificates of analysis and safety data sheets. As a European-based supplier, OYSI ensures compliance with local regulations including REACH requirements. Contact OYSI directly for availability, specifications, packaging options, and delivery throughout Europe while ensuring all regulatory requirements are met.