Cyclohexanamine
C6H13N
cyclohexanamine
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Identification
- CAS Number
- 108-91-8
- EC Number
- 203-629-0
- UN Number
- 2357
- Index Number
- 612-050-00-6
- PubChem CID
- 7965
Physical-chemical properties
- Molecular Formula
- C6H13N
- Molar Mass
- 99.17 g/mol
- IUPAC Name
- cyclohexanamine
Chemical Identifiers
- InChI
- InChI=1S/C6H13N/c7-6-4-2-1-3-5-6/h6H,1-5,7H2
- InChI Key
- PAFZNILMFXTMIY-UHFFFAOYSA-N
Overview
Cyclohexanamine (CAS 108-91-8) is a primary aliphatic amine featuring a cyclohexane ring structure with significant industrial applications and notable safety considerations. This cyclic amine compound, also known by its IUPAC name cyclohexanamine, represents an important building block in organic synthesis and industrial chemistry. With the molecular formula C6H13N and a molecular weight of 99.17 g/mol, cyclohexanamine exhibits the characteristic properties of primary amines while incorporating the structural stability of a saturated six-membered ring. The compound is classified under multiple hazard categories, including flammable liquid (Category 3), reproductive toxicity (Category 2), acute toxicity (Category 4), and skin corrosion (Category 1B), requiring careful handling protocols and appropriate safety measures. The substance's chemical structure makes it particularly valuable in the synthesis of various industrial chemicals and pharmaceutical intermediates. Like other aliphatic amines such as ethane-1,2-diamine, cyclohexanamine demonstrates strong basicity and nucleophilic properties, enabling its use in numerous chemical transformations. Its cyclic structure provides enhanced stability compared to linear amines while maintaining reactive amino functionality. Primary industrial applications include its use as an intermediate in pharmaceutical manufacturing, particularly in the synthesis of analgesics and other therapeutic compounds. The chemical also serves as a corrosion inhibitor in metalworking fluids and as a catalyst in polymerization processes. Additionally, cyclohexanamine finds application in the production of rubber accelerators and various specialty chemicals. Given its classification under ADR Class 8 (corrosive substances) and multiple GHS pictograms (GHS02, GHS08, GHS07, GHS05), proper storage, handling, and transportation protocols are essential. OYSI maintains reliable supplies of cyclohexanamine for European industrial customers, ensuring consistent quality and regulatory compliance for diverse technical applications.
Safety & Classification
Flam. Liq. 3; Repr. 2; Acute Tox. 4 *; Acute Tox. 4 *; Skin Corr. 1B
GHS Pictograms
Flame
GHS02
Flammable. May ignite on contact with air, water, or heat sources.
Health Hazard
GHS08
Serious health hazard. May cause cancer, organ damage, or genetic defects.
Exclamation Mark
GHS07
Harmful. May cause irritation, allergic reactions, or drowsiness.
Corrosion
GHS05
Corrosive. Causes severe skin burns and eye damage.
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Skin Contact
Measures if substance contacts the skin
Eye Contact
Measures if substance gets into the eyes
First Aid Actions
- +P305IF IN EYES:
- +P351Rinse cautiously with water for several minutes.
- +P338Remove contact lenses, if present and easy to do. Continue rinsing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Transport (ADR)
| UN Number | 2357 |
| ADR Class | 8 |
| Packing Group | II |
| Tunnel Code | D/E |
| Proper Shipping Name | Cyclohexylamin |
| Marine Pollutant | No |
Frequently Asked Questions
What is cyclohexanamine?
Cyclohexanamine is an organic compound with the chemical formula C6H13N and CAS number 108-91-8. It is a primary amine derived from cyclohexane, featuring a six-membered saturated carbon ring with an amino group (-NH2) attached. With a molecular weight of 99.17 g/mol, cyclohexanamine is classified as a hazardous substance requiring careful handling due to its flammable, toxic, and corrosive properties.
What are the physicochemical properties of cyclohexanamine?
Cyclohexanamine is a colorless to pale yellow liquid at room temperature with a strong, fishy ammonia-like odor. It is moderately soluble in water and miscible with most organic solvents including alcohols and ethers. The compound has a boiling point around 134°C and is lighter than water. Its basic nature (pKa ~10.6) makes it capable of forming salts with acids, and it readily absorbs moisture from air.
What is cyclohexanamine used for?
Cyclohexanamine serves primarily as an intermediate in chemical synthesis and industrial manufacturing. It is widely used in the production of nylon 6,6 precursors, rubber accelerators, and corrosion inhibitors. The compound also finds applications in the manufacture of pharmaceuticals, agrochemicals, and specialty chemicals. Additionally, it serves as a curing agent for epoxy resins and as a chemical intermediate in various organic synthesis processes.
How to handle cyclohexanamine safely?
Cyclohexanamine requires strict safety measures including wearing chemical-resistant gloves, safety goggles, and protective clothing. Work must be conducted in well-ventilated areas or under fume hoods to prevent inhalation exposure. Avoid contact with skin, eyes, and clothing, as the substance is corrosive and can cause severe burns. Keep away from heat sources, sparks, and open flames due to its flammable nature. Emergency shower and eyewash facilities should be readily accessible.
How to store cyclohexanamine correctly?
Cyclohexanamine must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition sources. Keep containers in secondary containment to prevent spills and avoid storage near incompatible materials such as strong acids, oxidizing agents, and reactive metals. Storage areas should be equipped with appropriate fire suppression systems and maintain temperatures below 25°C to prevent vapor buildup and degradation.
What to do in case of contact with cyclohexanamine?
Immediate action is required for cyclohexanamine exposure. For skin contact, remove contaminated clothing and flush affected areas with plenty of water for at least 15 minutes, then seek medical attention. If eyes are affected, rinse continuously with water for 15-20 minutes and remove contact lenses if present. For inhalation, move the person to fresh air immediately. In case of ingestion, do not induce vomiting and seek immediate medical care.
How to dispose of cyclohexanamine properly?
Cyclohexanamine disposal must comply with local and national hazardous waste regulations. The substance should never be poured down drains or disposed of with regular waste. Arrange disposal through licensed hazardous waste contractors who can properly treat or incinerate the material at authorized facilities. Small quantities may require neutralization before disposal, but this should only be done by trained personnel following established protocols and regulatory requirements.
How to transport cyclohexanamine?
Cyclohexanamine is classified under ADR as Class 8 (corrosive substances), Packing Group II, requiring specialized transportation procedures. It must be packaged in UN-approved containers with proper labeling including corrosive and flammable hazard markings. Transportation requires appropriate documentation, driver training, and emergency response information. Vehicles must be equipped with suitable fire extinguishers and spill control materials, and drivers must hold valid ADR certification for dangerous goods transport.
Is cyclohexanamine subject to specific regulations?
Cyclohexanamine is subject to comprehensive chemical regulations including REACH registration in Europe and CLP classification requirements. It is classified as Repr. 2 (reproductive toxicity), requiring special handling and labeling with GHS08 health hazard pictograms. The substance may be subject to workplace exposure limits and requires safety data sheets for commercial supply. Users must comply with industrial emissions regulations and may need permits for storage and use in certain quantities.
Where to buy cyclohexanamine in Europe?
Cyclohexanamine is available through OYSI, a leading European distributor of industrial chemicals. OYSI provides reliable supply chains across Europe with proper documentation, safety data sheets, and regulatory compliance support. As a specialized chemical distributor, OYSI ensures product quality, proper packaging, and adherence to transportation regulations. Contact OYSI directly for pricing, availability, and technical support for your cyclohexanamine requirements in the European market.
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Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.