1-chloro-2,3-dinitrobenzene

C6H3ClN2O4

CAS25567-67-3
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

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Identification

CAS Number
25567-67-3
EC Number
247-109-1
UN Number
1577
Index Number
610-003-00-4
PubChem CID
33096

Physical-chemical properties

Molecular Formula
C6H3ClN2O4
Molar Mass
202.55 g/mol
IUPAC Name
1-chloro-2,3-dinitrobenzene

Chemical Identifiers

InChI
InChI=1S/C6H3ClN2O4/c7-4-2-1-3-5(8(10)11)6(4)9(12)13/h1-3H
InChI Key
KYDXWCHDUCDNGR-UHFFFAOYSA-N

Overview

1-chloro-2,3-dinitrobenzene (CAS 25567-67-3) is a halogenated aromatic compound with high toxicity and significant environmental impact potential. This chlorinated dinitrobenzene derivative represents an important intermediate in organic synthesis, particularly valued for its reactive nitro groups and chlorine substituent that enable diverse chemical transformations. With a molecular formula of C6H3ClN2O4 and molecular weight of 202.55 g/mol, this compound exhibits the characteristic properties of polynitroaromatic substances, including enhanced electrophilic reactivity and potential for nucleophilic aromatic substitution reactions. The substance presents significant safety considerations, classified under multiple acute toxicity categories (Acute Tox. 3) for oral, dermal, and inhalation exposure routes, along with specific target organ toxicity concerns (STOT RE 2). Its environmental profile requires careful handling protocols, as it carries Aquatic Acute 1 and Aquatic Chronic 1 classifications, indicating severe hazards to aquatic life with long-lasting effects. The GHS pictograms GHS06, GHS08, and GHS09 reflect its toxic, health hazard, and environmental danger characteristics respectively. Industrial applications primarily focus on chemical synthesis where the compound serves as a building block for more complex molecules, particularly in pharmaceutical intermediates and specialty chemical production. Unlike simpler aromatic amines such as N-methylaniline or 2-chloroaniline, this dinitro compound offers unique reactivity patterns essential for specific synthetic pathways. The manufacturing of dyes, pigments, and agricultural chemical intermediates represents additional application areas where its distinctive substitution pattern proves valuable. OYSI maintains reliable supply chains for 1-chloro-2,3-dinitrobenzene, ensuring consistent availability for qualified industrial customers throughout Europe.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Aquatic Acute 1; Aquatic Chronic 1

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H400

Very toxic to aquatic life.

H410

Very toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1577
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping NameChlordinitrobenzene, Isomere oder Isomerengemisch, flüssig
Marine PollutantNo

Frequently Asked Questions

What is 1-chloro-2,3-dinitrobenzene?

1-chloro-2,3-dinitrobenzene is an aromatic compound with the molecular formula C6H3ClN2O4 and CAS number 25567-67-3. This chemical features a benzene ring substituted with one chlorine atom and two nitro groups in specific positions. With a molecular weight of 202.55 g/mol, it belongs to the class of chloronitrobenzenes, which are important chemical intermediates used in various industrial applications.

What are the physicochemical properties of 1-chloro-2,3-dinitrobenzene?

1-chloro-2,3-dinitrobenzene is typically a solid crystalline compound at room temperature with a characteristic aromatic odor. The presence of both electron-withdrawing nitro groups and chlorine substituent significantly affects its chemical reactivity and physical properties. Its molecular structure (C6H3ClN2O4) contributes to its stability under normal conditions, though specific data on melting point, boiling point, and solubility would require detailed technical specifications.

What is 1-chloro-2,3-dinitrobenzene used for?

1-chloro-2,3-dinitrobenzene serves as an important chemical intermediate in organic synthesis and industrial manufacturing processes. It is commonly used in the production of dyes, pigments, and pharmaceutical intermediates. The compound's reactive chlorine and nitro groups make it valuable for nucleophilic substitution reactions and reduction processes in fine chemical synthesis, particularly in the development of agrochemicals and specialty chemicals.

How to handle 1-chloro-2,3-dinitrobenzene safely?

1-chloro-2,3-dinitrobenzene requires careful handling due to its Acute Tox. 3 classification and STOT RE 2 properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and respiratory protection in well-ventilated areas. Avoid skin and eye contact, inhalation, and ingestion. Work in fume hoods when possible, use proper grounding procedures to prevent static buildup, and ensure emergency shower and eyewash stations are accessible.

How to store 1-chloro-2,3-dinitrobenzene correctly?

1-chloro-2,3-dinitrobenzene should be stored in a cool, dry, well-ventilated area away from heat sources and direct sunlight. Keep containers tightly sealed and store in original labeled packaging. Due to its toxic properties and environmental hazards (Aquatic Acute 1, Aquatic Chronic 1), maintain secure storage away from water sources. Separate from incompatible materials such as strong oxidizers and bases to prevent dangerous reactions.

What to do in case of contact with 1-chloro-2,3-dinitrobenzene?

Immediate action is required if contact with 1-chloro-2,3-dinitrobenzene occurs due to its acute toxicity. For skin contact, remove contaminated clothing and wash thoroughly with soap and water for at least 15 minutes. If eye contact occurs, flush immediately with clean water for 15 minutes. In case of inhalation, move to fresh air immediately. For ingestion, do not induce vomiting and seek medical attention immediately in all cases.

How to dispose of 1-chloro-2,3-dinitrobenzene properly?

1-chloro-2,3-dinitrobenzene must be disposed of as hazardous waste according to local and national regulations. Due to its environmental toxicity classification (Aquatic Acute 1, Aquatic Chronic 1), it cannot be disposed of in regular waste streams or sewerage systems. Contact licensed hazardous waste disposal companies for proper treatment, which typically involves high-temperature incineration in specialized facilities equipped with appropriate emission control systems.

How to transport 1-chloro-2,3-dinitrobenzene?

1-chloro-2,3-dinitrobenzene is classified as ADR Class 6.1 (toxic substances), Packing Group II, requiring specific transport protocols. Packages must bear appropriate hazard labels including GHS06, GHS08, and GHS09 pictograms with 'Danger' signal word. Use UN-approved packaging and ensure proper documentation including transport documents. Drivers must hold ADR certification for dangerous goods, and vehicles require appropriate equipment and emergency procedures for toxic substance transport.

Is 1-chloro-2,3-dinitrobenzene subject to particular regulations?

1-chloro-2,3-dinitrobenzene is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification obligations. While not currently listed as SVHC (Substance of Very High Concern), its Acute Tox. 3 and environmental hazard classifications impose strict handling, labeling, and safety data sheet requirements. Companies must comply with occupational exposure limits, environmental discharge restrictions, and waste management regulations specific to toxic substances.

Where to buy 1-chloro-2,3-dinitrobenzene in Europe?

1-chloro-2,3-dinitrobenzene is available through OYSI, a specialized European distributor of industrial chemicals and technical products. OYSI provides reliable supply chains for chemical intermediates with proper regulatory compliance and safety documentation. As a professional chemical distributor, OYSI ensures appropriate packaging, labeling, and transport documentation for hazardous materials like 1-chloro-2,3-dinitrobenzene, serving industrial customers across European markets with technical expertise and regulatory support.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.