Propyl formate

C4H8O2

propyl formate

CAS110-74-7
GHS02 Gefahrensymbol: Entzündbar – Flamme
GHS07 Gefahrensymbol: Gesundheitsschädlich/Reizend – Ausrufezeichen
Danger

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Identification

CAS Number
110-74-7
EC Number
203-798-0
UN Number
1281
Index Number
607-016-00-2
PubChem CID
8073

Physical-chemical properties

Molecular Formula
C4H8O2
Molar Mass
88.11 g/mol
IUPAC Name
propyl formate

Chemical Identifiers

InChI
InChI=1S/C4H8O2/c1-2-3-6-4-5/h4H,2-3H2,1H3
InChI Key
KFNNIILCVOLYIR-UHFFFAOYSA-N

Overview

Propyl formate (CAS 110-74-7) is an organic ester compound with characteristic fruity odor and high volatility properties. This colorless liquid ester, with the molecular formula C4H8O2, serves as an important industrial solvent and chemical intermediate in various manufacturing processes. Propyl formate exhibits typical ester characteristics, formed through the reaction between propionic acid and methanol, though it can also be synthesized via alternative pathways. The compound demonstrates good solubility in organic solvents while showing limited miscibility with water, making it particularly valuable in applications requiring selective extraction or separation processes. From a safety perspective, propyl formate requires careful handling due to its classification as a Category 2 flammable liquid with a relatively low flash point. The substance can cause eye irritation and specific target organ toxicity following single exposure, particularly affecting the central nervous system. Proper ventilation and fire prevention measures are essential when working with this material, as indicated by its ADR Class 3 transportation requirements and GHS02/GHS07 hazard pictograms. Industrial applications of propyl formate include its use as a solvent in coating formulations, printing inks, and adhesive systems where fast evaporation rates are desired. The compound also finds application in the production of flavoring agents and fragrances, leveraging its pleasant fruity aroma. In some processes, it serves alongside other organic solvents like ethylbenzene in specialized extraction applications, though each compound offers distinct volatility and selectivity characteristics. OYSI maintains reliable supply chains for propyl formate to support European industrial customers across multiple sectors.

Safety & Classification

Danger
Classification:

Flam. Liq. 2; STOT SE 3; STOT SE 3; Eye Irrit. 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H225

Highly flammable liquid and vapour.

H335

May cause respiratory irritation.

H336

May cause drowsiness or dizziness.

H319

Causes serious eye irritation.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Irritant

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Eye Contact

Irritant

Measures if substance gets into the eyes

First Aid Actions

  • +P305IF IN EYES:
  • +P351Rinse cautiously with water for several minutes.
  • +P338Remove contact lenses, if present and easy to do. Continue rinsing.
  • +P313Get medical advice/attention.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number1281
ADR Class3
Packing GroupII
Tunnel CodeD/E
Proper Shipping NamePropylformiat
Marine PollutantNo

Frequently Asked Questions

What is propyl formate?

Propyl formate is an organic chemical compound with the molecular formula C4H8O2 and CAS number 110-74-7. It belongs to the ester family, formed by the reaction between formic acid and propanol. With a molecular weight of 88.11 g/mol, this flammable liquid is classified as a Class 2 flammable liquid under GHS regulations and presents eye irritation and specific target organ toxicity hazards.

What are the physicochemical properties of propyl formate?

Propyl formate is a colorless liquid with a characteristic fruity, rum-like odor typical of formate esters. It has moderate solubility in water and is miscible with most organic solvents including alcohols and ethers. The compound has a relatively low boiling point and high volatility at room temperature, contributing to its flammable nature and potential for vapor formation.

What is propyl formate used for?

Propyl formate is primarily used as a solvent in various industrial applications, particularly in coatings, paints, and varnishes. It serves as a flavoring agent in the food industry due to its fruity aroma, and as a fragrance component in perfumery. Additionally, it finds application in chemical synthesis as a reagent and in the production of other organic compounds through esterification reactions.

How to handle propyl formate safely?

Propyl formate requires careful handling due to its flammable nature and irritant properties. Essential personal protective equipment includes safety goggles, chemical-resistant gloves, and appropriate respiratory protection when ventilation is inadequate. Work areas must be well-ventilated, and all ignition sources should be eliminated. Ground all equipment to prevent static discharge, and use explosion-proof electrical equipment in areas where vapors may accumulate.

How to store propyl formate correctly?

Propyl formate must be stored in a cool, dry, well-ventilated area away from heat sources, sparks, and open flames. Use appropriate containers made of compatible materials and ensure proper grounding of storage vessels. Keep away from strong oxidizing agents and acids to prevent dangerous reactions. Storage areas should be equipped with appropriate fire suppression systems and maintained below recommended temperature limits.

What to do in case of contact with propyl formate?

Propyl formate exposure requires immediate first aid measures depending on the route of contact. For eye contact, flush immediately with plenty of water for at least 15 minutes and seek medical attention due to its eye irritant properties. For skin contact, wash thoroughly with soap and water. If inhaled, move to fresh air immediately. In case of ingestion, do not induce vomiting and seek medical advice promptly.

How to dispose of propyl formate appropriately?

Propyl formate disposal must comply with local and national waste regulations as a flammable and potentially hazardous substance. The compound should be collected and disposed of through licensed waste management companies specializing in flammable organic solvents. Incineration at appropriate facilities or solvent recovery may be suitable disposal methods. Never discharge into drains, waterways, or soil due to environmental impact concerns.

How to transport propyl formate?

Propyl formate is classified under ADR Class 3 (flammable liquids), Packaging Group II, requiring specific transport regulations compliance. Vehicles must be equipped with appropriate safety equipment and operated by trained personnel with hazardous materials certification. Packages must bear proper hazard labels including GHS02 and GHS07 pictograms with 'Danger' signal word. Transportation documents must accompany shipments with proper technical names and classification codes.

Is propyl formate subject to specific regulations?

Propyl formate is regulated under European REACH regulation and must comply with CLP classification requirements. It is not currently listed as a Substance of Very High Concern (SVHC). The compound requires safety data sheets and appropriate hazard communication including GHS02 (flame) and GHS07 (exclamation mark) pictograms. Industrial users must implement risk management measures according to chemical safety assessments and workplace exposure limits.

Where to buy propyl formate in Europe?

Propyl formate is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI provides propyl formate with complete documentation including safety data sheets and certificates of analysis. The company serves various European markets with reliable supply chains for industrial customers requiring this flammable organic solvent for their manufacturing processes and applications.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.