Propyl carbonochloridate

Propyl carbonochloridate is an organic chemical compound with the molecular formula C4H7ClO2 and CAS number 109-61-5. This substance belongs to the family of chloroformate esters, characterized by its reactive nature due to the presence of both carbonyl and chloride functional groups. With a molecular weight of 122.55 g/mol, it is classified as a hazardous chemical requiring careful handling due to its flammable, toxic, and corrosive properties.

Propyl carbonochloridate is typically a colorless to pale yellow liquid at room temperature with a pungent, acrid odor characteristic of chloroformate compounds. The substance has a molecular weight of 122.55 g/mol and formula C4H7ClO2. It is moisture-sensitive and reacts readily with water, producing hydrochloric acid and carbon dioxide. The compound is soluble in organic solvents but decomposes in aqueous media, making it incompatible with water-based systems.

Propyl carbonochloridate is primarily used as an intermediate in organic synthesis and pharmaceutical manufacturing. It serves as a reagent for introducing propoxycarbonyl protecting groups in peptide synthesis and other organic transformations. The compound is also utilized in the production of carbamate derivatives, pharmaceuticals, and specialty chemicals. Its reactive nature makes it valuable for acylation reactions and as a building block in fine chemical synthesis within controlled industrial environments.

Propyl carbonochloridate requires strict safety measures including wearing full chemical-resistant PPE: nitrile gloves, safety goggles, face shield, and chemical-resistant clothing. Work must be conducted in a well-ventilated fume hood due to toxic vapor release. Avoid contact with skin, eyes, and inhalation of vapors. Keep away from heat sources, sparks, and open flames due to its flammable nature. Have emergency eyewash stations and safety showers readily accessible during handling operations.

Propyl carbonochloridate must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat, sparks, and ignition sources. Keep containers away from moisture and incompatible materials such as water, alcohols, amines, and strong bases. Store in original containers made of compatible materials, preferably glass or suitable plastic. Maintain storage temperature below 25°C and ensure proper labeling according to GHS requirements with appropriate hazard pictograms.

Propyl carbonochloridate exposure requires immediate action due to its corrosive nature. For skin contact, immediately remove contaminated clothing and flush affected area with copious amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with water for 15-20 minutes while holding eyelids open. If inhaled, move victim to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always consult a physician after any exposure incident.

Propyl carbonochloridate disposal must comply with local and national hazardous waste regulations as it is classified as toxic and corrosive waste. The substance should be collected in appropriate containers and disposed of through licensed hazardous waste disposal companies. Never discharge into sewers, water bodies, or soil. Small quantities may be carefully hydrolyzed under controlled conditions by qualified personnel, but this should only be done following proper safety protocols and environmental regulations.

Propyl carbonochloridate is classified under ADR Class 6.1 (Toxic substances), Packing Group I, indicating high toxicity requiring strict transport regulations. Packages must be properly labeled with GHS pictograms (GHS02, GHS06, GHS05) and appropriate shipping documentation. Transportation requires specialized vehicles and trained personnel familiar with hazardous materials handling. Containers must be securely fastened, leak-proof, and comply with UN packaging standards for toxic substances during road transport across Europe.

Propyl carbonochloridate is subject to multiple European regulations including REACH registration requirements, CLP classification as Flam. Liq. 2, Acute Tox. 3, and Skin Corr. 1B. It carries the signal word 'Danger' and requires appropriate GHS labeling. The substance is not currently listed as SVHC under REACH. Companies must maintain safety data sheets, implement risk management measures, and ensure worker protection according to occupational health regulations. Import/export may require additional permits depending on quantities and destinations.

Propyl carbonochloridate is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. OYSI provides this hazardous chemical with proper documentation, safety data sheets, and regulatory compliance support. As a professional chemical distributor, OYSI ensures appropriate packaging, labeling, and transport arrangements according to ADR regulations. Contact OYSI directly for availability, technical specifications, and regulatory guidance for your specific application requirements.