Methyl 2-chloroacetate

Methyl 2-chloroacetate is an organic chemical compound with the molecular formula C3H5ClO2 and CAS number 96-34-4. This chlorinated ester has a molecular weight of 108.52 g/mol and belongs to the family of haloacetic acid derivatives. It is classified as a hazardous substance with multiple danger classifications including flammable liquid, acute toxicity, and corrosive properties, requiring careful handling in industrial applications.

Methyl 2-chloroacetate is a liquid at room temperature with characteristic ester properties. As a chlorinated compound, it typically appears as a colorless to pale yellow liquid with a pungent odor. The substance has limited water solubility but is miscible with most organic solvents. Its flammable nature (Flam. Liq. 3) indicates a flash point between 23-60°C, making it moderately flammable under normal conditions.

Methyl 2-chloroacetate serves primarily as an important intermediate in organic synthesis and pharmaceutical manufacturing. It is commonly used in the production of various pharmaceuticals, agrochemicals, and fine chemicals through nucleophilic substitution reactions. The compound also finds applications in research laboratories for synthesizing amino acid derivatives and other specialized organic compounds, particularly in medicinal chemistry and crop protection product development.

Safe handling requires appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection in poorly ventilated areas. Work should be conducted in well-ventilated spaces or under fume hoods due to its acute toxicity classification. Avoid contact with skin and eyes, as the substance causes severe eye damage and skin irritation. Keep away from ignition sources and ensure proper grounding during transfer operations.

Proper storage requires cool, dry, well-ventilated areas away from heat sources and incompatible materials. Store in tightly sealed original containers made of compatible materials, typically glass or specific plastics. Keep away from strong bases, oxidizing agents, and reactive metals. Storage areas should have appropriate fire suppression systems and spill containment measures. Maintain temperatures below 25°C to prevent vapor buildup and degradation.

Immediate action is crucial due to the substance's corrosive and toxic nature. For skin contact, remove contaminated clothing and rinse affected areas with plenty of water for at least 15 minutes. In case of eye contact, flush immediately with water for 15-20 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention while providing safety data sheet information.

Disposal must comply with local, national, and international hazardous waste regulations due to its classification as dangerous goods. The substance should never be discharged into sewers or the environment. Contact licensed hazardous waste disposal companies for proper treatment, which typically involves high-temperature incineration in specialized facilities. Small laboratory quantities may require neutralization following approved protocols before disposal. Always consult current waste disposal regulations in your jurisdiction.

Transportation is regulated under ADR classification 6.1 (toxic substances) with Packing Group I, indicating high danger level. Proper shipping containers must meet UN specification requirements and display appropriate hazard labels including toxic and flammable markings. Shipping documents must include proper shipping names, hazard classes, and emergency response information. Only authorized carriers with dangerous goods training should handle transportation, following strict packaging and labeling requirements.

Yes, methyl 2-chloroacetate is subject to comprehensive chemical regulations including REACH registration requirements in Europe and CLP classification obligations. Its multiple hazard classifications mandate specific labeling, safety data sheet provisions, and workplace exposure controls. The substance requires professional user restrictions and may be subject to authorization procedures depending on usage volumes and applications. Regular regulatory updates should be monitored for compliance requirements.

Methyl 2-chloroacetate is available through specialized chemical distributors across Europe, including OYSI, which supplies high-quality chemical products to industrial customers throughout the European market. As a controlled hazardous substance, purchases typically require demonstration of legitimate industrial use and proper handling capabilities. Buyers should ensure suppliers provide complete regulatory documentation, including safety data sheets and certificates of analysis for quality assurance.