Butyl carbonochloridate

Butyl carbonochloridate is an organochlorine chemical compound with the molecular formula C5H9ClO2 and CAS number 592-34-7. This substance belongs to the family of chloroformate esters, characterized by its reactive carbonyl chloride functional group. With a molecular weight of 136.58 g/mol, it presents significant hazards including flammability, acute toxicity, and corrosive properties, requiring careful handling in industrial applications.

Butyl carbonochloridate is typically a colorless to pale yellow liquid at room temperature with a pungent, acrid odor characteristic of chloroformates. The compound is moisture-sensitive and reacts readily with water, releasing hydrogen chloride gas. It has limited solubility in water due to hydrolysis reactions but is miscible with most organic solvents. Its flammable nature (Flam. Liq. 3) indicates a flash point between 23°C and 60°C.

Butyl carbonochloridate is primarily used as a chemical intermediate in organic synthesis and pharmaceutical manufacturing. It serves as an acylating agent for introducing butoxycarbonyl protecting groups in peptide synthesis and pharmaceutical research. The compound is also utilized in the production of carbamate pesticides, polymers, and specialty chemicals. Its reactive chloroformate functionality makes it valuable for creating carbamate linkages and protecting amino groups in complex organic molecules.

Butyl carbonochloridate requires strict safety measures due to its corrosive (Skin Corr. 1B) and acutely toxic (Acute Tox. 3) properties. Essential personal protective equipment includes chemical-resistant gloves, safety goggles, face shield, and protective clothing. Work must be conducted in well-ventilated areas or under fume hoods to avoid inhalation exposure. Emergency eyewash stations and safety showers should be readily accessible, and all personnel must be trained in proper handling procedures.

Butyl carbonochloridate must be stored in tightly sealed containers in a cool, dry, well-ventilated area away from heat sources and ignition points. The storage area should be separated from incompatible materials such as water, alcohols, amines, and strong bases, which can cause violent reactions. Containers should be made of compatible materials and regularly inspected for signs of corrosion or leakage. Temperature control is essential to prevent decomposition and vapor buildup.

Immediate action is required for any contact with butyl carbonochloridate due to its corrosive nature. For skin contact, remove contaminated clothing and flush affected areas with copious amounts of water for at least 15 minutes. In case of eye contact, rinse immediately with water for at least 15 minutes and seek medical attention. If inhaled, move to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention while providing safety data sheet information.

Butyl carbonochloridate disposal must comply with local, national, and EU waste regulations as it is classified as hazardous waste. The substance should never be discharged into drains, soil, or waterways. Proper disposal typically involves incineration at authorized high-temperature facilities equipped with appropriate emission controls. Small quantities may be neutralized carefully under controlled conditions by qualified personnel. Always consult with licensed waste disposal companies and provide complete safety data sheet information.

Butyl carbonochloridate is classified under ADR transport regulations as Class 6.1 (toxic substances), Packing Group II, indicating moderate to high toxicity. Transport must comply with all ADR requirements including proper packaging, labeling with appropriate hazard pictogramms (GHS02, GHS06, GHS05), and documentation. Vehicles must carry appropriate emergency equipment and drivers require hazardous materials training. Shipping containers must be compatible with the chemical and properly secured to prevent damage during transit.

Butyl carbonochloridate is subject to multiple European regulations including CLP (Classification, Labelling and Packaging) regulation requiring hazard classification as Flam. Liq. 3, Acute Tox. 3, and Skin Corr. 1B with 'Danger' signal word. Under REACH regulation, it requires registration for manufacture or import above specified tonnages. The substance is not currently listed as SVHC (Substance of Very High Concern), but users must comply with occupational exposure limits and safety requirements under relevant national legislation.

Butyl carbonochloridate is available through OYSI, a specialized European distributor of technical chemicals serving industrial and research customers across Europe. As a professional chemical supplier, OYSI ensures proper packaging, documentation, and compliance with all relevant safety and transport regulations. Contact OYSI directly for availability, technical specifications, safety data sheets, and delivery options to your specific location within Europe. All purchases require appropriate business credentials and intended use documentation.