N,N-diethylaniline

N,N-diethylaniline is an organic chemical compound with the molecular formula C10H15N and CAS number 91-66-7. This aromatic amine belongs to the aniline derivative family, featuring two ethyl groups attached to the nitrogen atom of the aniline structure. With a molecular weight of 149.23 g/mol, it is classified as a hazardous substance requiring careful handling due to its acute toxicity and potential health effects.

N,N-diethylaniline is typically a colorless to pale yellow liquid at room temperature with a characteristic amine odor. As an organic compound, it exhibits limited solubility in water but shows good solubility in organic solvents such as alcohols, ethers, and hydrocarbons. Its aromatic structure and tertiary amine functionality contribute to its chemical stability and reactivity patterns typical of substituted anilines.

N,N-diethylaniline is primarily used as an intermediate in chemical synthesis and pharmaceutical manufacturing. It serves as a building block for producing dyes, pigments, and various organic compounds. The substance finds applications in the synthesis of pharmaceutical intermediates and specialty chemicals. Its tertiary amine structure makes it valuable for chemical reactions requiring nucleophilic substitution and as a catalyst in certain organic transformations.

N,N-diethylaniline requires strict safety measures due to its Acute Tox. 3 classification and DANGER signal word. Personal protective equipment must include chemical-resistant gloves, safety goggles, and appropriate respiratory protection. Work should be conducted in well-ventilated areas or under fume hoods. Avoid skin and eye contact, and prevent inhalation of vapors. The GHS06, GHS08, and GHS09 pictograms indicate acute toxicity, health hazards, and environmental dangers.

N,N-diethylaniline should be stored in tightly sealed containers in a cool, dry, and well-ventilated area away from heat sources and direct sunlight. Storage areas must be equipped with appropriate containment measures to prevent environmental release, given its Aquatic Chronic 2 classification. Keep containers upright and check regularly for leaks. Store separately from incompatible materials and ensure access is restricted to trained personnel only.

In case of skin contact with N,N-diethylaniline, immediately remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. For eye contact, flush immediately with clean water for 15-20 minutes. If inhaled, move the person to fresh air immediately. Due to its acute toxicity classification, seek immediate medical attention in all cases of exposure and provide the safety data sheet to medical personnel.

N,N-diethylaniline disposal must comply with local and European waste regulations due to its hazardous classification. The substance should never be poured down drains or released into the environment given its Aquatic Chronic 2 classification. Contact licensed waste disposal companies for proper treatment and disposal. Waste containers must be properly labeled and handled according to hazardous waste protocols. Consider recovery or recycling options when available.

N,N-diethylaniline is classified under ADR Class 6.1 (toxic substances), Packing Group III, requiring specific transport regulations. Packages must bear appropriate hazard labels and markings according to dangerous goods regulations. Transport vehicles need proper placarding and documentation. Only trained personnel should handle the transportation, and emergency response information must be readily available. Containers must meet UN specification requirements for Class 6.1 substances.

N,N-diethylaniline is subject to European REACH and CLP regulations due to its hazardous properties. While not currently listed as a SVHC (Substance of Very High Concern), it requires registration under REACH for manufacturing or import above one tonne per year. The substance must be classified and labeled according to CLP regulation with appropriate hazard statements. Users must maintain safety data sheets and implement appropriate risk management measures.

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