1-methyl-4-nitrobenzene

C7H7NO2

CAS99-99-0
GHS06 Gefahrensymbol: Giftig – Totenkopf mit Knochen
GHS08 Gefahrensymbol: Gesundheitsgefahr – Gesundheitsgefahr
GHS09 Gefahrensymbol: Umweltgefährlich – Umwelt
Danger

Consulting for 1-methyl-4-nitrobenzene

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Identification

CAS Number
99-99-0
EC Number
202-808-0
UN Number
3446
Index Number
609-006-00-3
PubChem CID
7473

Physical-chemical properties

Molecular Formula
C7H7NO2
Molar Mass
137.14 g/mol
IUPAC Name
1-methyl-4-nitrobenzene

Chemical Identifiers

InChI
InChI=1S/C7H7NO2/c1-6-2-4-7(5-3-6)8(9)10/h2-5H,1H3
InChI Key
ZPTVNYMJQHSSEA-UHFFFAOYSA-N

Overview

1-methyl-4-nitrobenzene (CAS 99-99-0) is an aromatic nitro compound with yellow crystalline appearance and distinctive chemical reactivity properties. This organic compound, also known by its IUPAC designation 1-methyl-4-nitrobenzene, represents a significant intermediate in industrial chemical synthesis. With the molecular formula C7H7NO2 and a molecular weight of 137.14 g/mol, this substance features a benzene ring substituted with both a methyl group and a nitro group in para positions, creating a compound with unique chemical properties essential for various manufacturing processes. The compound exhibits notable safety considerations, classified under multiple acute toxicity categories and requiring careful handling protocols. Its classification includes Acute Tox. 3 across multiple exposure routes, STOT RE 2 for repeated exposure effects, and Aquatic Chronic 2 for environmental impact. The assigned danger signal word and GHS pictograms GHS06, GHS08, and GHS09 reflect its potential health hazards and environmental concerns. Transportation regulations classify it under ADR Class 6.1, emphasizing the need for specialized logistics management. In industrial applications, 1-methyl-4-nitrobenzene serves primarily as a chemical intermediate in the production of pharmaceuticals, dyes, and specialized organic compounds. The compound finds particular utility in synthesis processes where selective reduction or further functionalization is required. Its structural relationship to compounds like 5-methyl-2-nitroaniline demonstrates its position within the broader family of substituted aromatic nitro compounds used in fine chemical manufacturing. The manufacturing industry also employs this compound in the production of agricultural chemicals and polymer additives, where its specific reactivity profile provides advantages in multi-step synthesis routes. OYSI maintains reliable supply chains for 1-methyl-4-nitrobenzene, ensuring consistent availability for European industrial customers requiring this specialized chemical intermediate.

Safety & Classification

Danger
Classification:

Acute Tox. 3 *; Acute Tox. 3 *; Acute Tox. 3 *; STOT RE 2 *; Aquatic Chronic 2

HHazard Statements (H-Statements)

Describe the nature and severity of the hazard

H331

Toxic if inhaled.

H311

Toxic in contact with skin.

H301

Toxic if swallowed.

H373

May cause damage to organs through prolonged or repeated exposure.

H411

Toxic to aquatic life with long lasting effects.

Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).

First Aid Measures

Inhalation

Toxic

Measures if vapours or dust are inhaled

First Aid Actions

  • +P304IF INHALED:
  • +P340Remove person to fresh air and keep comfortable for breathing.
  • +P311Call a POISON CENTER/doctor.

Related hazard statements:

Skin Contact

Toxic

Measures if substance contacts the skin

First Aid Actions

  • +P302IF ON SKIN:
  • +P352Wash with plenty of water.
  • +P361Take off immediately all contaminated clothing.
  • +P313Get medical advice/attention.

Related hazard statements:

Ingestion

Toxic

Measures if substance is accidentally swallowed

First Aid Actions

  • +P301IF SWALLOWED:
  • +P330Rinse mouth.
  • +P331Do NOT induce vomiting.
  • +P310Immediately call a POISON CENTER/doctor.

Related hazard statements:

General Measures

Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)

First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.

Transport (ADR)

UN Number3446
ADR Class6.1
Packing GroupII
Tunnel CodeD/E
Proper Shipping Name4-Nitrotoluen, fest
Marine PollutantNo

Frequently Asked Questions

What is 1-methyl-4-nitrobenzene?

1-methyl-4-nitrobenzene is an aromatic nitro compound with the molecular formula C7H7NO2 and CAS number 99-99-0. This organic chemical features a benzene ring substituted with a methyl group and a nitro group in para position. With a molecular weight of 137.14 g/mol, it serves as an important intermediate in chemical synthesis and industrial processes.

What are the physicochemical properties of 1-methyl-4-nitrobenzene?

1-methyl-4-nitrobenzene is typically a pale yellow crystalline solid at room temperature with a characteristic aromatic odor. This nitroaromatic compound has limited solubility in water but dissolves well in organic solvents like ethanol, benzene, and ether. It exhibits stability under normal conditions but can be sensitive to strong reducing agents and high temperatures.

What is 1-methyl-4-nitrobenzene used for?

1-methyl-4-nitrobenzene is primarily used as an intermediate in the synthesis of dyes, pharmaceuticals, and agrochemicals. It serves as a precursor for producing various aniline derivatives through reduction processes. The compound finds applications in manufacturing pigments, rubber chemicals, and specialty organic compounds in industrial settings requiring controlled chemical transformations.

How to handle 1-methyl-4-nitrobenzene safely?

1-methyl-4-nitrobenzene requires careful handling due to its acute toxicity classification (Acute Tox. 3). Always wear appropriate personal protective equipment including chemical-resistant gloves, safety goggles, and respiratory protection. Work in well-ventilated areas or under fume hoods, avoid skin contact and inhalation, and ensure emergency eyewash stations and safety showers are accessible during handling operations.

How to store 1-methyl-4-nitrobenzene correctly?

1-methyl-4-nitrobenzene should be stored in a cool, dry, well-ventilated area away from heat sources and incompatible materials. Keep containers tightly sealed and protect from light and moisture. Store separately from strong reducing agents, alkali metals, and oxidizing substances to prevent dangerous reactions. Maintain storage temperatures below 25°C for optimal stability.

What to do in case of contact with 1-methyl-4-nitrobenzene?

In case of skin contact with 1-methyl-4-nitrobenzene, immediately remove contaminated clothing and wash affected areas thoroughly with soap and water for at least 15 minutes. If inhaled, move to fresh air immediately. For eye contact, rinse with clean water for 15 minutes. Seek immediate medical attention for any exposure, as this substance can cause systemic toxicity.

How to dispose of 1-methyl-4-nitrobenzene appropriately?

1-methyl-4-nitrobenzene must be disposed of as hazardous waste according to local and national regulations. Contact licensed hazardous waste disposal companies for proper treatment and disposal. Never discharge into sewers, waterways, or soil. Small quantities may require incineration at high temperatures in specialized facilities equipped with appropriate emission controls and scrubbing systems.

How to transport 1-methyl-4-nitrobenzene?

1-methyl-4-nitrobenzene is classified as ADR Class 6.1 (toxic substances), Packing Group II for transportation purposes. It requires appropriate hazardous goods packaging, labeling with GHS06, GHS08, and GHS09 pictograms, and proper shipping documentation. Transport must comply with dangerous goods regulations and be handled by trained personnel with appropriate emergency response procedures.

Is 1-methyl-4-nitrobenzene subject to specific regulations?

1-methyl-4-nitrobenzene is subject to REACH registration requirements and CLP classification regulations in Europe. It carries multiple hazard classifications including acute toxicity and environmental hazards, requiring appropriate safety data sheets and labeling. While not currently listed as an SVHC substance, it must comply with occupational exposure limits and environmental protection regulations in industrial use.

Where to buy 1-methyl-4-nitrobenzene in Europe?

1-methyl-4-nitrobenzene is available through OYSI, a specialized European distributor of technical chemicals. As an established chemical supplier, OYSI provides this compound to industrial customers with proper documentation, safety data sheets, and regulatory compliance support. Contact OYSI directly for availability, specifications, and pricing information for your specific application requirements.

Data Sources

Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.