1-methyl-4-nitrobenzene

1-methyl-4-nitrobenzene is an aromatic nitro compound with the molecular formula C7H7NO2 and CAS number 99-99-0. This chemical consists of a benzene ring substituted with a methyl group at position 1 and a nitro group at position 4. With a molecular weight of 137.14 g/mol, it belongs to the class of mononitrotoluenes and is classified as a dangerous substance due to its acute toxicity and potential for causing specific target organ toxicity upon repeated exposure.

1-methyl-4-nitrobenzene typically appears as a pale yellow crystalline solid or liquid at room temperature. It has a characteristic aromatic odor and is slightly soluble in water but readily dissolves in organic solvents such as ethanol, ether, and benzene. The compound has a melting point around 51-54°C and a boiling point of approximately 238°C. It is stable under normal conditions but can decompose when exposed to strong heat or incompatible materials.

1-methyl-4-nitrobenzene is primarily used as an intermediate in the synthesis of various chemical compounds, particularly in the production of dyes, pigments, and pharmaceuticals. It serves as a precursor for the manufacture of p-toluidine through reduction processes and is utilized in the synthesis of various organic compounds in the chemical industry. The substance is also employed in research and development applications for organic synthesis and as a building block for more complex molecular structures.

1-methyl-4-nitrobenzene requires careful handling due to its acute toxicity classification (Acute Tox. 3). Essential personal protective equipment includes chemical-resistant gloves, safety goggles, and appropriate respiratory protection when ventilation is inadequate. Work should be conducted in well-ventilated areas or under fume hoods to prevent inhalation. Avoid skin and eye contact, and ensure no ingestion occurs. Emergency shower and eyewash stations should be readily accessible, and personnel should be trained in proper handling procedures.

1-methyl-4-nitrobenzene should be stored in a cool, dry, well-ventilated area away from heat sources, ignition sources, and direct sunlight. Use appropriate chemical storage cabinets designed for toxic substances, ensuring containers are tightly sealed to prevent vapor release. Store separately from incompatible materials such as strong oxidizers, reducing agents, and bases. Maintain storage temperatures below 25°C when possible and ensure proper labeling according to GHS requirements including the danger signal word and appropriate pictograms.

Immediate action is required upon contact with 1-methyl-4-nitrobenzene due to its acute toxicity. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water for at least 15 minutes. In case of eye contact, flush immediately with clean water for 15-20 minutes while holding eyelids open. If inhaled, move the person to fresh air immediately. For ingestion, do not induce vomiting and seek immediate medical attention. Always contact emergency services or poison control centers for serious exposures.

1-methyl-4-nitrobenzene must be disposed of as hazardous waste in accordance with local, national, and EU regulations. The substance cannot be disposed of in regular waste streams due to its toxicity and environmental hazard classification (Aquatic Chronic 2). Contact licensed hazardous waste disposal companies for proper collection and treatment. Incineration at authorized facilities with appropriate emission controls is typically the preferred disposal method. Always consult local environmental authorities for specific disposal requirements and maintain proper waste documentation.

1-methyl-4-nitrobenzene is classified under ADR as Class 6.1 (toxic substances), Packing Group II, indicating significant transport hazards. Transportation requires appropriate dangerous goods packaging, labeling, and documentation according to ADR regulations. Vehicles must display proper hazard placards, and drivers need ADR certification for Class 6.1 substances. Packages must bear the correct UN identification number, proper shipping name, and hazard labels. Emergency response information must accompany shipments, and specific routing restrictions may apply in urban areas.

1-methyl-4-nitrobenzene is subject to comprehensive EU chemical regulations including REACH registration requirements and CLP classification obligations. While not currently listed as a Substance of Very High Concern (SVHC), it must comply with standard chemical safety data sheet requirements and hazard communication protocols. The substance is classified under multiple hazard categories requiring specific risk management measures. Companies handling this chemical must ensure proper registration, evaluation, and authorization procedures are followed according to REACH regulation requirements.

1-methyl-4-nitrobenzene is available through OYSI, a specialized European distributor of technical chemicals. OYSI provides this substance to qualified industrial and research customers across Europe, ensuring full regulatory compliance and proper documentation. As a professional chemical distributor, OYSI maintains appropriate safety data sheets, certificates of analysis, and regulatory documentation required for this hazardous substance. Contact OYSI directly for availability, technical specifications, and pricing information for your specific application requirements.