Ethyl nitrite
C2H5NO2
ethyl nitrite
Consulting for Ethyl nitrite
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Identification
- CAS Number
- 109-95-5
- EC Number
- 203-722-6
- UN Number
- Index Number
- 007-006-00-2
- PubChem CID
- 8026
Physical-chemical properties
- Molecular Formula
- C2H5NO2
- Molar Mass
- 75.07 g/mol
- IUPAC Name
- ethyl nitrite
Chemical Identifiers
- InChI
- InChI=1S/C2H5NO2/c1-2-5-3-4/h2H2,1H3
- InChI Key
- QQZWEECEMNQSTG-UHFFFAOYSA-N
Overview
Ethyl nitrite (CAS 109-95-5) is an organic nitrite ester with volatile properties and characteristic sweet odor used in pharmaceutical and chemical synthesis applications. This highly volatile compound, with molecular formula C2H5NO2 and molecular weight of 75.07 g/mol, represents an important member of the alkyl nitrite family. Ethyl nitrite appears as a colorless to pale yellow gas or liquid at room temperature, demonstrating significant volatility due to its relatively low boiling point. The compound exhibits characteristic chemical reactivity typical of nitrite esters, making it valuable for various synthetic processes. From a safety perspective, ethyl nitrite requires careful handling due to its classification as a flammable gas (Flam. Gas 1) and pressurized gas (Press. Gas), along with acute toxicity concerns (Acute Tox. 4). The compound carries GHS pictograms GHS02 (flame), GHS04 (gas cylinder), and GHS07 (exclamation mark), with "Danger" as the signal word. These classifications necessitate appropriate ventilation systems, flame-free environments, and proper personal protective equipment during handling and storage operations. In industrial applications, ethyl nitrite serves primarily as an intermediate in pharmaceutical synthesis, particularly in the production of certain organic compounds where nitrite functionality is required. The compound also finds use in specialized chemical synthesis reactions and as a reagent in analytical chemistry procedures. Its reactivity profile differs notably from simpler compounds like ethene, offering unique synthetic pathways for complex molecular construction. The volatile nature and specific handling requirements of ethyl nitrite make it essential for users to implement comprehensive safety protocols and ensure compliance with relevant transportation and storage regulations. OYSI provides ethyl nitrite to qualified industrial customers across Europe, supporting pharmaceutical and chemical manufacturing operations with reliable supply chain solutions.
Safety & Classification
Flam. Gas 1; Press. Gas; Acute Tox. 4 *; Acute Tox. 4 *; Acute Tox. 4 *
GHS Pictograms
HHazard Statements (H-Statements)
Describe the nature and severity of the hazard
Classification according to CLP Regulation (EC) No 1272/2008. The complete list of hazard and precautionary statements can be found in the Safety Data Sheet (SDS).
First Aid Measures
Inhalation
Measures if vapours or dust are inhaled
First Aid Actions
- +P304IF INHALED:
- +P340Remove person to fresh air and keep comfortable for breathing.
- +P311Call a POISON CENTER/doctor.
Related hazard statements:
Skin Contact
Measures if substance contacts the skin
First Aid Actions
- +P302IF ON SKIN:
- +P352Wash with plenty of water.
- +P361Take off immediately all contaminated clothing.
- +P313Get medical advice/attention.
Related hazard statements:
Ingestion
Measures if substance is accidentally swallowed
First Aid Actions
- +P301IF SWALLOWED:
- +P330Rinse mouth.
- +P331Do NOT induce vomiting.
- +P310Immediately call a POISON CENTER/doctor.
Related hazard statements:
General Measures
Emergency 112 | Poison Control: +49 30 19240 (DE), +33 1 45 42 59 59 (FR), +31 30 274 88 88 (NL)
First aid measures are based on CLP classification and associated P-statements. They do not replace the Safety Data Sheet (SDS). In case of emergency, always consult the full SDS and a physician.
Frequently Asked Questions
What is ethyl nitrite?
Ethyl nitrite is an organic chemical compound with the molecular formula C2H5NO2 and CAS number 109-95-5. It has a molecular weight of 75.07 g/mol and belongs to the nitrite ester family. This compound is classified as a flammable and pressurized gas with acute toxicity properties. Ethyl nitrite appears as a colorless gas with a characteristic sweet odor and is highly volatile at room temperature.
What are the physicochemical properties of ethyl nitrite?
Ethyl nitrite is a colorless gas at room temperature with a sweet, fruity odor. It has a molecular weight of 75.07 g/mol and exists as a pressurized gas under normal storage conditions. The compound is highly volatile and flammable, with good solubility in organic solvents like alcohol and ether. It decomposes readily when exposed to light and heat, making it unstable under certain environmental conditions.
What is ethyl nitrite used for?
Ethyl nitrite is primarily used as a vasodilator in pharmaceutical applications and as an intermediate in organic synthesis. It serves as a nitrosating agent in chemical reactions and finds application in the production of other organic compounds. The substance is also used in research laboratories for various analytical and synthetic purposes. Its vasodilatory properties make it valuable in certain medical formulations, though its use is strictly regulated due to safety concerns.
How to handle ethyl nitrite safely?
Ethyl nitrite requires careful handling due to its flammable and toxic nature. Always wear appropriate personal protective equipment including safety goggles, chemical-resistant gloves, and work in well-ventilated areas or under fume hoods. Avoid all sources of ignition, heat, and sparks. Handle containers gently to prevent pressure buildup and ensure proper grounding of equipment. Never smoke or use open flames in areas where ethyl nitrite is present.
How to store ethyl nitrite correctly?
Ethyl nitrite must be stored in cool, dry, well-ventilated areas away from heat sources, direct sunlight, and ignition sources. Keep containers tightly sealed and store under pressure as a gas in appropriate cylinders. Avoid storage near oxidizing agents, acids, and bases due to potential incompatibilities. Storage areas should be equipped with appropriate fire suppression systems and maintained below recommended temperature limits to prevent decomposition.
What to do in case of contact with ethyl nitrite?
Ethyl nitrite exposure requires immediate action due to its acute toxicity. In case of inhalation, move the person to fresh air immediately and seek medical attention. For skin contact, remove contaminated clothing and wash the affected area thoroughly with soap and water. If eye contact occurs, flush eyes with clean water for at least 15 minutes. Always seek professional medical advice promptly after any exposure incident.
How to dispose of ethyl nitrite properly?
Ethyl nitrite disposal must comply with local and international hazardous waste regulations due to its classification as dangerous goods. Contact licensed hazardous waste disposal companies for proper handling and treatment. Never dispose of ethyl nitrite through regular waste streams or sewage systems. Empty containers should also be treated as hazardous waste. Consult local environmental authorities for specific disposal requirements and approved disposal facilities in your region.
How to transport ethyl nitrite?
Ethyl nitrite transport requires compliance with dangerous goods regulations due to its flammable gas and acute toxicity classifications. The substance must be transported in approved pressure vessels designed for gas transport, with proper labeling including GHS02, GHS04, and GHS07 pictograms and 'Danger' signal word. Ensure proper documentation, trained personnel, and emergency response procedures are in place during transportation according to international transport regulations.
Is ethyl nitrite subject to specific regulations?
Ethyl nitrite is subject to various regulatory frameworks including REACH registration requirements in Europe and CLP classification obligations. The substance is classified under multiple hazard categories (Flam. Gas 1, Press. Gas, Acute Tox. 4) requiring specific safety data sheets and labeling. It is not currently listed as an SVHC substance, but users must comply with occupational exposure limits and safety protocols established by local regulatory authorities.
Where to buy ethyl nitrite in Europe?
Ethyl nitrite is available through specialized chemical distributors in Europe, including OYSI, which serves as a reliable supplier of technical chemicals across European markets. When purchasing, ensure the supplier provides proper documentation, safety data sheets, and compliance with REACH regulations. Due to its hazardous classification, purchases may require specific qualifications or licenses depending on intended use and local regulations in your country.
Data Sources
Classification per CLP Regulation (EC) No 1272/2008. Data from ECHA and PubChem.